Curriculum Vitae
PART I: General Information
| Date prepared: | May, 2007 |
| Name: | Li-Huei Tsai |
| Office Address: | The Picower Institute for Learning and Memory |
| Department of Brain and Cognitive Sciences | |
| Howard Hughes Medical Institute | |
| Massachusetts Institute of Technology | |
| 77 Massachusetts Avenue | |
| Building 46, Room 4235A | |
| Cambridge, MA 02139 |
| Office: | 617-324-1660 |
| E-Mail: | lhtsai@mit.edu |
| Fax: | 617 324 1657 |
| Website: | http://web.mit.edu/lhtsai/www/ |
| Place of Birth: | Taipei, Taiwan |
| Education: | ||
| 1983 | D.V.M. | National Chung Hsing University, Taichung, Taiwan |
| 1986 | M.S. | University of Wisconsin, Madison, WI |
| 1990 | Ph.D. | University of Texas Southwestern Medical Center, Dallas, TX |
| Postdoctoral Training: | |
| 1990 | Harlow Lab, Cold Spring Harbor Laboratory, NY |
| 1990-94 | Harlow Lab, Massachusetts General Hospital Cancer Center, MA |
| Academic Appointments: | |
| 1994 -1999 | Assistant Professor, Department of Pathology Harvard Medical School, Boston, MA |
| 1999-2002 | Associate Professor, Department of Pathology Harvard Medical School, Boston, MA |
| 1997-2002 | Assistant Investigator, Department of Pathology Howard Hughes Medical Institute, Boston, MA |
| 2002-2006 | Professor, Department of Pathology Harvard Medical School, Boston, MA |
| 2002-present | Investigator, Howard Hughes Medical Institute Boston, MA |
2006-present |
Picower Professor, Picower Institute for Learning and Memory Department of Brain and Cognitive Sciences Massachusetts Institute of Technology |
2006-present |
Investigator, Riken-MIT Neuroscience Research Center Massachusetts Institute of Technology |
2006-present |
Associate Member, Broad Institute |
2007-present |
Director, Neurobiology Program Stanley Center for Psychiatric Research |
Outside Service Related to Professional Work
1998-2000 |
NIH Study Section (ad hoc)- Molecular, cellular and developmental processes in neural and other excitable cells (MDCN-2) |
2001-2003 |
NIH Study Section - Molecular, cellular and developmental processes in neural and other excitable cells (MDCN-2) |
2003-present |
NIH Study Section – Neurogenesis and Cell Fate (NCF) |
2003-present |
NINDS Board of Scientific Counselors |
2005-2006 |
Scientific Advisory Board, Alzheimer Research Forum Foundation |
2005-present |
Scientific Advisory Board, Sirtris Pharmaceuticals Inc. |
2006-present |
Expert Advisory Committee, Hotchkiss Brain Institute, University of Calgary |
2006- present |
ASBMB Meetings Committee |
Editorial Boards:
Ad hoc reviewer for: Cell, Neuron, Nature, Science, Nature Cell Biology, Nature Neuroscience, Nature Genetics, Journal of Neuroscience, Molecular and Cellular Biology, Journal of Neurochemistry, New England Journal of Medicine, Cell Growth and Differentiation, Proceedings of National Academy of Sciences USA, Molecular Biology of Cell
2002- Editorial Board, NeuroSignals
2005- Reviewing Editor, the Journal of Neuroscience
Honors and Awards:
| Leukemia Society of America Special Fellowship | 1992-1995 |
| Milton Fund Award | 1994 |
| Hurst Fund Award | 1995 |
| Rita Allen Scholarship | 1996-2001 |
| Klingenstein Fellowship in the Neurosciences | 1997-2000 |
| Metropolitan Life Foundation | 2001 |
| Alzheimer’s Association | 2002-2005 |
| Outstanding Contributor Award, Alzheimer Research Forum |
2004 |
| Alzheimer’s Research Consortium | 2003-2006 |
PART II: Bibliography
A. Original Articles in Refereed Journals:
1. Tsai L-H, Collins MT, Hoiby N. Antigenic analysis of Pasteurella haemolytics serovars 1 through
15 by crossed immuoelectrophoresis. Am J Vet Res 1988;49:213-22.
2. Chen Q, Cheng JT, Tsai L-H, Scheneider N, Buchanan G, Carroll A, Crist W, Ozanne B, Siciliano MJ,
Baer R. The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes
a helix-loop-helix protein. EMBO J 1990 ;9:415-24.
3. Tsai L-H, Nanu L, Smith RG, Ozanne B. Overexpression of c-fos in a human pre-B cell acute
lymphocytic leukemia derived cell line, SMS-SB. Oncogene 1990;6:81-8.
4. Tsai L-H, Harlow E, Meyerson M. Isolation of the human cdk2 gene that encodes the cyclin A- and
adenovirus E1A-associated p33 kinase. Nature 1991;353:174-77.
5. Faha B, Ewen M, Tsai L-H, Livingston D, Harlow E. Association between human cyclin A and
adenovirus E1A-associated p107 protein. Science 1992;255:87-90.
6. Meyerson M, Enders G, Wu CL, Su LK, Gorka C, Nelson C, Harlow E, Tsai L-H. A family of human
cdc2-related protein kinases. EMBO J 1992;11:2909-17.
7. Cao L, Faha B, Dembski M, Tsai L-H, Harlow E, Dyson N. Independent binding of the retinoblastoma
protein and p107 to the transcription factor E2F. Nature 1992;355:176-179.
8. Tsai LH, Lees E, Faha B, Harlow E, Riabowol K. The cdk2 kinase is required for the G1-to-S phase
transition in mammalian cells. Oncogene 1993;8:1593-1602.
9. Tsai L-H, Takahashi T, Caviness V, Harlow E. Activity and expression pattern of cyclin-dependent
kinase 5 in the embryonic mouse nervous system. Development 1993;119: 1029-40.
- Tsai L-H, White L, Raines E, Ross R, Smith RG, Cushley W, Ozanne B. Expression of platelet-
derived growth factor and its receptors by two pre-B acute lymphocytic leukemia cell lines. Blood
1994:83: 51-5.
- Tsai L-H, Delalle I, Caviness V, Chae T, Harlow E. p35, a neural specific regulatory subunit of the
Cdk5 kinase. Nature 1994;371: 419-23.
- Harper JW, Elledge SJ, Keyomarsi K, Dynlacht B, Tsai L-H, Zhang P, Dobrowolski S, Bai C,
Connell-Crowley L, Swindell E, Fox MP, Wei N. Inhibition of cyclin-dependent kinases by p21. Mol Biol Cell
1995;6: 387-400.
13. Missero C, Calautti E, Eckner R, Chin J, Tsai L-H, Livingston DM, Dotto GP. Involvement of the cell
cycle inhibitor Cip1/WAF1 and the transcriptional modulator p300 in terminal differentiation.
Pro Natl Acad Sci USA 1995;92: 5451-55.
14. Lee MH, Nikolic M, Baptista CA, Lai E, Tsai L-H, Massague J. The brain-specific activator p35
allows Cdk5 to escape inhibition by p27kip1 in neurons. Pro Natl Acad Sci USA 1996;93: 3259-63.
15. Guidato S, Tsai L-H, Woodgett J, Miller CC. Differential cellular phosphorylation of
neurofilament heavy side-arms by glycogen synthase kinase-3 and cyclin-dependent kinase-5. J
Neurochem 1996;66:1698-706.
16. Nikolic M, Dudek H, Kwon YT, Ramos YFM, Tsai L-H. The Cdk5/p35 kinase is essential for neurite
outgrowth during neuronal differentiation. Genes and Devel 1996;8:816-25.
- Fero ML, Rivkin M, Tasch M, Porter P, Carow CE, Firpo E, Tsai L-H, Broudy V, Perlmutter RM,
Kaushansky K, Roberts JM. A syndrome of multi-organ hyperplasia with features of gigantism, tumorigenesis
and female sterility in p27Kip1-deficient mice. Cell 1996;85: 733-44.
- Songyang Z, Lu KP, Kwon YT, Tsai L-H, Filhol O, Cochet C, Brickey DA, Soderling TR, Bartleson C, Graves
- DJ, Demaggio AJ, Hoekstra MF, Blenis J, Hunter T, Cantley LC. A structural basis for substrate specificities
- of protein ser/thr kinases-primary sequence preference of casein kinases I and II, NIMA, phosphorylase kinase,
- calmodulin-dependent kinase II, Cdk5 and ERK1. Mol Cell Biol
1996;16:6486-93.
19. Chae T, Kwon YT, Bronson R, Dikkes P, Li E, Tsai L-H. Mice lacking p35, a neuronal specific
activator of Cdk5, display cortical lamination defects, seizures and adult lethality. Neuron
1997;18, 29-42.
- Delalle I, Bhide PG, Caviness VS Jr, Tsai L-H. Temporal and spatial patterns of expression of p35,
- a regulator subunit of cyclin-dependent kinase 5, in the nervous system of the mouse. J Neurocytol
1997;26:283-396.
21. Philpott A, Porro EB, Kirschner MK, Tsai L-H. The role of cyclin-dependent kinase 5 and a novel
regulatory subunit in regulating muscle differentiation and patterning. Genes and Devel 1997;11:1409-21.
- Kwon YT, Tsai L-H. A novel disruption of cortical development in p35-/- mice distinct from reeler. J
Comp. Neurol 1998;395:510-22.
23. Patrick GN, Zhou P, Kwon YT, Howley PM, Tsai L-H. p35, the neuronal specific activator of Cdk5,
is degraded by the ubiquitin-proteasome pathway. J Biol Chem 1998;273:24057-63.
24. Nikolic M, Chou MM, Lu W, Mayer BJ, Tsai L-H. The p35/Cdk5 kinase is a neuronal specific Rac
effector that inhibits Pak1 activity. Nature 1998;395:194-98.
- Philpott A, Tsai L-H, Kirschner MW. Neuronal differentiation and patterning in Xenopus: the role of Cdk5
and a novel activator Xp35.2. Dev. Biol 1999;207:119-32.
- Delalle I, Takahashi T, Nowakowski RS, Tsai L-H, Caviness VS Jr. Cyclin E - p27 opposition and regulation
of the G1 phase of the cell cycle in the murine neocortical PVE: A quantitative analysis of mRNA in situ hybridization.
Cerebral Cortex 1999;9:824-32.
27. Huang D, Patrick G, Moffat J, Tsai L-H, Andrews B. Mammalian Cdk5 is a functional homologue of
the budding yeast Pho85 cyclin-dependent protein kinase. Pro. Natl. Acad. Sci. USA 1999;96:
14445-450.
28. Bibb JA, Synder GL, Nishi A, Zhen Y, Meijer L, Fienberg AA, Tsai L-H, Kwon YT, Girault JA,
Czernik AJ, Huganir RL, Hemmings HC Jr, Nairn AC, Greengard P. Phosphorylation of DARPP-32
by Cdk5 modulates dopamine signalling in neurons. Nature 1999;402: 669-71.
29. Kwon YT, Tsai L-H, Crandall JE. Callosal axon guidance defects in p35-/- mice. J Comp Neurol
1999;415: 218-29.
30. Patrick GN, Zukerberg L, Nikolic M, de la Monte S, Dikkes P, Tsai L-H. Conversion of p35 to p25
deregulates Cdk5 activity and promotes neurodegeneration. Nature 1999;402:615-22.
- Humbert S, Dhavan R, Tsai L-H. p39 activates Cdk5 in neurons, and is associated with the actin
cytoskeleton. J Cell Sci 1999;113: 975-83.
32. Kwon YT, Gupta A, Zhou Y, Nikolic M, Tsai L-H. Regulation of the N-cadherin-mediated
adhesion by the p35/Cdk5 kinase. Curr Biol 2000;10:363-72.
33. Lee MS, Kwon YT, Li M, Peng J, Friedlander RM, Tsai L-H. Neurotoxicity induces cleavage of p35 to p25
by calpain. Nature 2000;405: 360-64.
34. Zukerberg LR, Patrick GN, Nikolic M, Humbert S, Lanier LM, Gertler FB, Vidal M, Van Etten RA,
Tsai L-H. Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase up-regulation,
and neurite outgrowth. Neuron 2000;26: 633-46.
35. Humbert S, Lanier LM, Tsai L-H. Synaptic localization of p39, a neuronal activator of Cdk5.
Neuroreport 2000;11: 2213-16.
36. Smith DS, Niethammer M, Ayala R, Zhou Y, Gambello MJ, Wynshaw-Boris A, Tsai L-H.
Regulation of cytoplasmic dynein behavior and microtubule organization by mammalian Lis1. Nat
Cell Biol 2000;2:767-75.
37 Niethammer M, Smith DS, Ayala R, Peng J, Ko J, Lee MS, Morabito M, Tsai L-H. Nudel is a novel
Cdk5 substrate that associates with Lis1 and cytoplasmic dynein. Neuron 2000;28: 697-711.
- Floyd SR, Porro EB, Slepnev VI, Ochoa GC, Tsai L-H, De Camilli P. Amphiphysin 1 Binds the
Cyclin-dependent Kinase (cdk) 5 Regulatory Subunit p35 and Is Phosphorylated by
Cdk5 and cdc2 . J Biol Chem 2001;276: 8104-10
39. Wenzel HJ, Robbins CA, Tsai L-H, Schwartzkroin PA. Abnormal morphological and functional
organization of the hippocampus in a p35 mutant model of cortical dysplasia associated with spontaneous seizures.
J Neurosci 2001;21(3):983-98.
40. Ko J, Humbert S, Bronson RT, Takahashi S, Kulkarni AB, Li E, Tsai, L-H. p35 and p39 are essential for cyclin-dependent
kinse 5 function during neurodevelopment. J Neurosci. 2001, 21: 6758-71.
41. Tarricone C, Dhavan R, Peng J, Areces LB, Tsai L-H*, Musacchio A*. Structure and regulation of the CDK5-p25nck5a complex.
Mol Cell 2001, 8: 657-69. *Contributed equally.
42. Ross S, Tienhaara A, Lee MS, Tsai L-H, Gill G. GC-box binding transcription factors control the neuronal specific transcription of
the cyclin-dependent kinase 5 regulator p35. J Biol Chem 2002; 277: 4455-4464.
43. Patzke H, Tsai L-H. Calpain-mediated cleavage of the Cyclin-dependent kinase-5 activator p39 to p29. J BIol
Chem 2002; 277: 8054-8060.
44. Tseng HC, Zhou Y, Shen, Tsai LH. A survey of Cdk5 activator p35 and p25 levels in Alzheimer’s disease brains.
FEBS Lett 2002; 523: 58-62.
45. Dhavan R, Greer PL, Morabito MA, Orlando LR, and Tsai L-H. The Cyclin-Dependent Kinase 5 Activators p35
and p39 Interact with the -Subunit of Ca2+/Calmodulin-Dependent Protein Kinase II and -Actinin-1 in a Calcium-Dependent
Manner. J Neurosci 2002;22(18):7879-7891.
46. Patzke, H, Maddineni U, Ayala R, Morabito M, Volker J, Dikkes P, Ahlijanian MK, Tsai L-H. Partial rescue of
the p35-/- brain phenotype by low expression of a NSE p25-transgene. J Neurosci 2003; 23(7):2769.
47. Toyo-oka K, Shionoya A, Gambello MJ, Cardoso C, Leventer R, Ward HL, Ayala R, Tsai L-H, Dobyns W, Ledbetter
D, Hirotsune, S, Wynshaw-Boris A. 14-3-3 epsilon is important for neuronal migration by binding to NUDEL: a
molecular explanation for Miller-Dieker syndrome. Nat Genet. 2003; 34: 274-85.
48. Xie Z, Sanada K, Samuels B, Shih H, Tsai L-H. Serine 732 Phosphorylation of FAK by Cdk5 is
Important for Microtubule Organization, Nuclear Movement and Neuronal Migration. Cell 2003; 114: 469-482.
49. Lee M-S, Kao S-c, Lemere CA, Xia W, Tseng H-C, Zhou Y, Neve R, Ahlijanian MK, Tsai L-H. APP
Processing is Regulated by Cytoplasmic Phosphorylation. J Cell Biol 2003, 163:83-95.
50. Cruz JC, Tseng H-C, Goldman JA, Shih H, Tsai L-H. Aberrant Cdk5 activation by p25 triggers pathological events
leading to neurodegeneration and neurofibrillary tangles. Neuron 2003 , 40: 471-483.
51. Gupta A, Sanada K, Miyamoto DT, Rovelstad S, Pearlman AL, Brunstrom J, Tsai L-H. The layering defect in p35 deficiency
is linked to radial migration with improper neuronal-glial interaction. Nat Neurosci 2003, 6: 1284-1291.
52. Kao SC, Krichevsky AM, Kosic K, Tsai, L-H. BACE1 suppression by RNA interference in primary cortical neurons.
J Biol Chem 2004, 279: 1942-1949.
53. Hammond V, Tsai L-H, Tan SS. Control of cortical neuron migration and layering: cell and non cell-autonomous
effects of p35. J Neurosci 2004, 24: 576-87.
54. Tanaka T, Serneo FF, Tseng H-C, Kulkarni AB, Tsai L-H, Gleeson JG. Cdk5 phosphorylation of
doublecortin Ser297 regulates its effect on neuronal migration. Neuron 2004, 41:215-227.
55. Morabito MA, Sheng M, Tsai L-H. The cyclin-dependent kinase 5 phosphorylates the N-terminal
domain of the postsynaptic density protein PSD95 in neurons. J Neurosci 2004, 24: 865-876.
56. Beffert U, Weeber E, Morfini G, Ko J, Brady ST, Tsai LH, Sweatt JD, Herz J. Reelin and cyclin-dependent kinase
5-dependent signals cooperate in regulating neuronal migration and synaptic transmission. J Neurosci 2004, 24: 1897-1906.
57. Sanada K, Gupta A, Tsai L-H. Disabled-1-regulated adhesion of migrating neurons to radial glial fiber contributes to
neuronal positioning during early corticogenesis. Neuron 2004, 22: 197-211.
58. Nguyen MD, Shu T, Sanada K, Lariviere RC, Tseng,HC, Park SK, Julien JP, Tsai L-H. A
NUDEL dependent mechanism of Neurofilament assembly regulates the integrity of CNS
neurons. Nat Cell Biol 2004, 6: 597-608.
59. Shu T, Ayala R, Nguyen MD, Xie Z, Gleeson JG, Tsai L-H. Ndel1 operates in a common pathway with Lis1 and
cytoplasmic dynein to regulate cortical neuronal positioning. Neuron 2004, 44: 263-277.
60. Moy LY, Tsai L-H. Cyclin-dependent kinase 5 phosphorylates serine 31 of tyrosine hydroxylase and regulates its stability.
J Biol Chem 2004, Epub ahead of print.
61. Tarricone C, Perrina F, Monzani S, Massimiliano L, Kim MH, Derewenda ZS, Knapp S, Tsai LH, Musacchio A. Coupling
PAF signaling to dynein regulation; structure of Lis1 in complex with PAF-acetylhydrolase. Neuron 2004, 809-821.
62. Mapelli M, Massimiliano L, Crovace C, Seeliger MA, Tsai LH, Meijer L, Musacchio A. Mechanism of Cdk5/p25 binding by
Cdk inhibitors. J Med Chem 2005, 48(3): 671-9.
63. Sanada K, Tsai L-H. G protein beta/gamma subunits and AGS3 control spindle orientation and asymmetric cell fate of
cerebral cortical progenitors. Cell 2005, 122: 119-131.
64. Tseng H-C, Ovaa H, Wei N, Ploegh H, Tsai L-H. Phosphoproteomic analysis using a novel solid-phase capture-release-tag
approach. Chemistry and Biology 2005, 12: 769-777.
65. Park, SK, Nguyen MD, Fischer A, Luke MP, Affar EB, Dieffenbach, PB, Tseng HC, Shi Y, Tsai L-H. Par4 links dopamine
signaling and depression. Cell 2005, 122: 275-287.
66. Fischer A, Sananbenesi F, Pang PT, Lu B, Tsai L-H. Opposing roles of transient and prolonged expression of p25 in
synaptic plasticity and hippocampus-dependent memory. Neuron, 2005, 48: 825-838.
- Shu T., Tseng H.C., Zhou Y., Fischer A., Stern P., Coquelle F., Reiner O., Tsai L.-H. Doublecortin-like Kinase
- Controls Neurogenesis by Regulating the Mitotic Spindle. Neuron 2006, 49:25-39.
68. Cruz JC, Kim D, Moy LY, Dobbin MM, Sun X, Bronson RT, Tsai, L-H. p25/Cdk5 induces production and
intraneuronal accumulation of amyloid beta in vivo. J Neurosci 2006, 26: 10536-41.
69. Fischer A, Sananbenesi F, Wang X, Dobbin M, Tsai, L-H. Recovery of long-term memories is associated with
chromatin remodeling. Nature, 447: 178-182.
70. Yip YP, Capriotti C, Drill E, Tsai LH, Yip J. Cdk5 Selectively Affects the Migration of Different Populations of
Neurons in the Developing Spinal Cord. Journal of Comparative Neurology 2007, 503:297-307.
71. Kim D, Nguyen MD, Fischer A, Sananbenesi F, Dobbin MM, Rodgers JT, Delalle I, Baur JA, Sui G, Armour SM,
Puigsrver P, Sinclair DA, Tsai L-H. SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer’s
disease and amyotrophic lateral sclerosis. EMBO J, in press.
B. Reviews, Chapters and Editorials
1. Meyerson M, Faha B, Su LK, Harlow E, Tsai L-H. The cyclin-dependent kinase family. In The Cell
Cycle, Cold Spring Harbor Symposium on Quantitation Biology, 1991 56:177-186. D. Beach, B.
2. Stillman and J. Watson (eds), Cold Spring Harbor Laboratory Press. Faha B, Meyerson M, Tsai L-H.
Adenovirus E1A targets one of two cyclin A-kinase complexes. Pezcoller Foundation Symposium
1992;3:107-30.
3. Caviness VS Jr, Takahashi T, Miyama S, Tsai L-H. Cytogenesis in the developing mouse neocortex.
In: Brain lesions in the newborn. Alfred Benzon Symposium 1994;37:25-42.
4. Tsai L-H. Stuck on the ECM. Trends in Cell Biol 1998;8:292-295.
5. Kwon YT, Tsai L-H. The role of the p35/Cdk5 kinase in cortical development. In: Mouse Brain
Development, Springer-Verlag 2000;30:241-51.
6. Nikolic M, Tsai L-H. Activity and regulation of p35/Cdk5 kinase complex. In: Methods in
Enzymology, Academic Press 2000;325:200-13.
7. Lee M-S, Tsai L-H. Cdk5 at the junction. News and Views, Nat Neurosci 2001; 4: pp340-342.
8. Gupta A, Tsai L-H. A kinase to dampen the effects of cocaine? Science 2001;292:236-237.
9. Smith DS, Greer PL, Tsai L-H. Cdk5 on the brain. Cell Growth Differ 2001;12:277-283.
10. Dhavan R, Tsai L-H. A decade of Cdk5. Nat Rev Mol Cell Biol. 2001; 2: 749-759.
11. Smith DS, Tsai L-H. Cdk5 behind the wheel: a role in tranfficking and transport. Trends Cell Biol
2002; 12: 28-36.
12. Patzke H, Tsai L-H. Cdk5 sinks into ALS. Trends Neurosci. 2002; 25:8-10.
13. Gupta A, Tsai L-H, Wynshaw-Boris A. Life is a journey: a genetic look at neocortical development.
Nat. Rev Gene, 2002;3:342-55.
14. Lee, M-S, Tsai L-H. Cdk5: One of the links between senile plaques and neurofibrillary tangles?
J Alzh Dis. 2003;5:127-137.
15. Samuels BA, Tsai L-H. Cdk5 is a dynamo at the synapse. Nat Cell Biol. 2003; 5: 689-690.
16. Gupta A, Tsai L-H. Cyclin-dependent kinase 5 and neuronal migration in the neocortex. Neurosignals. 2003; 12:173-179.
17. Xie Z, Tsai L-H. Cdk5 phosphorylation of FAK regulates centrosome-associated microtubules and neuronal migration.
Cell Cycle. 2004; 3: 108-110.
18. Tsai L-H, Lee MS, Cruz JC. Cdk5, a therapeutic target for Alzheimer’s disease? Biochim Biophys Acta. 2004;
1697: 137-142.
- Cruz JC, Tsai L-H. A Jekyll and Hyde kinase: roles for Cdk5 in brain development and disease. Curr Opin
- Neurobiol. 2004; 14: 390-394.
- Cruz JC, Tsai L-H. Cdk5 deregulation in the pathogenesis of Alzheimer’s disease. Trends Mol Med. 2004; 10: 452-8.
- Samuels BA, Tsai L-H. Nucleokinesis illuminated. Nat Neurosci 2004; 7:1169-1170.
- Tsai L-H, Gleeson JG. Nucleokinesis in neuronal migration. Neuron 2005; 46: 383-388.
- Xie Z, Samuels BA, Tsai L-H. Cyclin-dependent kinase 5 permits efficient cytoskeletal remodeling—a hypothesis on
- neuronal migration. Cereb Cortex. 2006: Suppl 1: i64-8.
- Ayala R, Shu T, Tsai L-H. Trekking across the brain: the journey of neuronal migration. Cell 2007; 128: 29-43.
- Buchman JJ, Tsai L-H. Spindle regulation in neural precursors of flies and mammals. Nat Rev Neurosci; 2007: 89-100.