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Publications |
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| Tsai LH, Harlow E, Meyerson M. Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase. Nature 1991;353:174-77. |
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| Faha B, Ewen M, Tsai L-H, Livingston D, Harlow E. Association between human cyclin A and adenovirus E1A-associated p107 protein. Science 1992;255:87-90. |
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| Meyerson M, Enders G, Wu CL, Su LK, Gorka C, Nelson C, Harlow E, Tsai LH. A family of human cdc2-related protein kinases. EMBO J 1992;11:2909-17. |
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| Tsai LH, Lees E, Faha B, Harlow E, Riabowol K. The cdk2 kinase is required for the G1-to-S phase transition in mammalian cells. Oncogene 1993;8:1593-1602. |
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| Tsai LH, Takahashi T, Caviness V, Harlow E. Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system. Development 1993;119: 1029-40. |
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| Tsai L-H, White L, Raines E, Ross R, Smith RG, Cushley W, Ozanne B. Expression of platelet derived growth factor and its receptors by two pre-B acute lymphocytic leukemia cell lines. Blood 1994:83: 51-5. |
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| Tsai LH, Delalle I, Caviness V, Chae T, Harlow E. p35, a neural specific regulatory subunit of the cdk5 kinase. Nature 1994;371: 419-23. |
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| 1996 |
| Nikolic M, Dudek H, Kwon YT, Ramos YFM, Tsai LH. The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation. Genes and Devel 1996;8:816-25. |
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| 1997 |
| Delalle I, Bhide PG, Caviness VS Jr, Tsai LH. Temporal and spatial patterns of expression of p35, a regulator subunit of cyclin-dependent kinase 5, in the nervous system of the mouse. J Neurocytol 1997;26:283-396. |
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| Philpott A, Porro EB, Kirschner MK, Tsai LH. The role of cyclin-dependent kinase 5 and a novel regulatory subunit in regulating muscle differentiation and patterning. Genes and Devel 1997;11:1409-21. |
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| 1998 |
| Kwon YT, Tsai LH. A novel disruption of cortical development in p35-/- mice distinct from reeler. J Comp. Neurol 1998;395:510-22. |
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| Patrick GN, Zhou P, Kwon YT, Howley PM, Tsai LH. p35, the neuronal specific activator of cdk5, is degraded by the ubiquitin-proteasome pathway. J Biol Chem 1998;273:24057-63. |
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| Nikolic M, Chou MM, Lu W, Mayer BJ, Tsai LH. The p35/cdk5 kinase is a neuronal specific Rac effector that inhibits Pak1 activity. Nature 1998;395:194-98. |
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| 1999 |
| Huang D, Patrick G, Moffat J, Tsai LH, Andrews B. Mammalian Cdk5 is a functional homologue of the budding yeast Pho85 cyclin-dependent protein kinase. Pro Natl Acad Sci USA 1999;96:14445-450. |
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| Kwon YT, Tsai LH, Crandall JE. Callosal axon guidance defects in p35-/- mice. J Comp Neurol 1999;415: 218-29. |
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| Patrick GN, Zukerberg L, Nikolic M, de la Monte S, Dikkes P, Tsai LH. Conversion of p35 to p25 deregulates cdk5 activity and promotes neurodegeneration. Nature 1999;402:615-22. |
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| Humbert S, Dhavan R, Tsai LH. p39 activates cdk5 in neurons, and is associated with the actin cytoskeleton. J Cell Sci 1999;113: 975-83. |
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| 2000 |
| Kwon YT, Gupta A, Zhou Y, Nikolic M, Tsai LH. Regulation of the N-cadherin-mediated adhesion by the p35/Cdk5 kinase. Curr Biol 2000;10:363-72. |
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| Lee MS, Kwon YT, Li M, Peng J, Friedlander RM, Tsai LH. Neurotoxicity induces cleavage of p35 to p25 by calpain. Nature 2000;405: 360-64. |
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| Zukerberg LR, Patrick GN, Nikolic M, Humbert S, Lanier LM, Gertler FB, Vidal M, Van Etten RA, Tsai LH. Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase up-regulation, and neurite outgrowth. Neuron 2000;26: 633-46. |
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| Humbert S, Lanier LM, Tsai LH. Synaptic localization of p39, a neuronal activator of cdk5. Neuroreport 2000;11: 2213-16. |
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| Smith DS, Niethammer M, Ayala R, Zhou Y, Gambello MJ, Wynshaw-Boris A, Tsai LH. Regulation of cytoplasmic dynein behavior and microtubule organization by mammalian Lis1. Nat Cell Biol 2000;2:767-75. |
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| Niethammer M, Smith DS, Ayala R, Peng J, Ko J, Lee MS, Morabito M, Tsai LH. Nudel is a novel Cdk5 substrate that assoicates with Lis1 and cytoplasmic dynein. Neuron 2000;28: 697-711. |
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| 2001 |
| Ko J, Humbert S, Bronson RT, Takahashi S, Kulkarni AB, Li E, Tsai LH. p35 and p39 are essential for Cdk5 function during neurodevelopment. J. Neurosci 2001;21:6758-71. |
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| Tarricone C, Dhavan R, Peng J, Areces LB, Tsai L-H*, Musacchio A*. Structure and regulation of the CDK5-p25nck5a complex. Mol Cell 2001,8: 657-69. |
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| 2002 |
| Ross S, Tienhaara A, Lee MS, Tsai L-H, Gill G. GC-box binding transcription factors control the neuronal specific transcription of the cyclin-dependent kinase 5 regulator p35. J Biol Chem 2002, 2002 277: 4455-4464. |
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| Patzke H, Tsai L-H. Calpain-mediated cleavage of the Cyclin-dependent kinase-5 activator p39 to p29. J BIol Chem 2002 277: 8054-8060. |
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| Dhavan R, Greer PL, Morabito MA, Orlando LR, and Tsai L-H. The Cyclin-Dependent Kinase 5 Activators p35 and p39 Interact with the -Subunit of Ca2+/Calmodulin-Dependent Protein Kinase II and -Actinin-1 in a Calcium-Dependent Manner. J Neurosci 2002;22(18):7879-7891. |
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| 2003 |
| Patzke H, Maddineni U, Ayala R, Morabito M, Volker J, Dikkes P, Ahlijanian MK, Tsai L-H. Partial rescue of the p35-/- brain phenotype by low expression of a NSE p25-transgene. J Neurosci 2003;23(7):2769. |
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| Xie Z, Sanada K, Samuels B, Shi H, Tsai L-H. Serine 732 Phosphorylation of FAK by Cdk5 is Important for Microtubule Organization, Nuclear Movement and Neuronal Migration. Cell 2003;114:469-482. |
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| Lee M-S, Kao S-c, Lemere CA, Xia W, Tseng H-C, Zhou Y, Neve R, Ahlijanian MK, Tsai L-H. APP Processing is Regulated by Cytoplasmic Phosphorylation. J Cell Bio 2003;163:83-95. |
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| Cruz J, Tseng H-C, Goldman J, Shi H, Tsai L-H. Aberrant Cdk5 Activation by p25 Triggers
Pathological Events Leading to Neurodegeneration and Neurofibrillary Tangles. Neuron 2003;40:471-483. |
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| Gupta A, Sanada K, Miyamoto DT, Rovelstad S, Pearlman AL, Brunstrom J, Tsai L-H. The
layering defect in p35 deficiency is linked to radial migration with improper neuronal-glial
interaction. Nat Neurosci 2003;6:1284-1291. |
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| 2004 |
| Kao SC, Krichevsky AM, Kosic K, Tsai L-H . BACE1 suppression by RNA interference in primary cortical neurons. J Biol Chem, 2004 Jan 16;279(3):1942-9. |
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| Hammond V, Tsai L-H, Tan SS. Control of cortical neuron migration and layering: cell and non cell-autonomous effects of p35. J Neurosci 2004;24:576-87. |
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| Tanaka T, Serneo FF, Tseng H-C, Kulkarni AB, Tsai L-H, Gleeson JG. Cdk5 phosphorylation of doublecortin Ser297 regulates its effect on neuronal migration . Neuron 2004;41:215-227. |
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| Morabito MA, Sheng M, Tsai L-H. The cyclin-dependent kinase 5 phosphorylates the N-terminal domain of the postsynaptic density protein PSD95 in neurons. J Neurosci, J Neurosci 2004;24:865-876. |
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| Beffert U, Weeber Ej, Morfini G, Ko J, Brady ST, Tsai LH, Sweatt JD, Herz J. Reelin and cyclin-dependent kinase 5-dependent signals cooperate in regulating neuronal migration and synaptic transmission. J Neurosci 2004;24:1897-1906. |
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| Sanada K, Gupta A, Tsai L-H. Disabled-1-regulated adhesion of migrating neurons to radial glial fiber contributes to neuronal positioning during early corticogenesis. Neuron 2004, 22: 197-211. |
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| Nguyen MD, Shu T, Sanada K, Lariviere RC, Tseng HC, Park SK, Julien JP, Tsai LH. A NUDEL-dependent mechanism of Neurofilament assembly regulates the integrity of CNS neurons. Nat Cell Biol, 2004, 6: 597-608. |
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| Shu T, Ayala R, Nguyen MD, Xie Z, Gleeson JG, Tsai LH. Ndel1 Operates in a Common Pathway with LIS1 and Cytoplasmic Dynein to Regulate Cortical Neuronal Positioning. Neuron 2004, 44(2):263-77. |
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| Moy LY, Tsai LH. Cyclin-dependent kinase 5 phosphorylates serine 31 of tyrosine hydroxylase and regulates its stability. J Biol Chem. 2004 Dec 24;279(52):54487-93. |
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| 2005 |
| Mapelli M, Massimiliano L, Crovace C, Seeliger MA, Tsai LH, Meijer L, Musacchio A. Mechanism of Cdk5/p25 binding by Cdk inhibitors. J Med Chem 2005, 48(3): 671-9. |
| Sanada K, Tsai LH. G Protein betagamma Subunits and AGS3 Control Spindle Orientation and Asymmetric Cell Fate of Cerebral Cortical Progenitors. Cell. 2005 Jul 15;122(1):119-31. |
Tseng HC, Ovaa H, Wei N, Ploegh H, Tsai LH. Phosphoproteomic analysis using a novel solid-phase apture-release-tag approach. Chemistry and Biology 2005, 12: 769-777. |
| Park SK, Nguyen MD, Fischer A, Luke MP, Affar EB, Dieffenbach PB, Tseng HC, Shi Y, Tsai LH. Par4 links dopamine signaling and depression. Cell 2005, 122: 275-287. |
| Fischer A, Sananbenesi F, Pang PT, Lu B, Tsai LH. Opposing roles of
transient and prolonged expression of p25 in synaptic plasticity and
hippocampus-dependent memory. Neuron, 2005 , 48: 825-838. |
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| 2006 |
Shu T, Tseng HC, Zhou Y, Fischer A, Stern P, Coquelle F, Reiner O, Tsai LH. Doublecortin-like KinaseControls Neurogenesis by Regulating the Mitotic Spindle. Neuron 2006, 5;49(1):25-39.
| Cruz JC, Kim D, Moy LY, Dobbin MM, Sun X, Bronson RT, Tsai, L-H. p25/Cdk5 induces production and intraneuronal accumulation of amyloid beta in vivo. J Neurosci 2006, 26: 10536-41. |
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| 2007 |
Fischer A, Sananbenesi F, Wang X, Dobbin M, Tsai, L-H. Recovery of long-term memories is associated with chromatin remodeling. Nature 2007, 447: 178-182. |
| Yip YP, Capriotti C, Drill E, Tsai LH, Yip J. Cdk5 Selectively Affects the Migration of Different Populations of Neurons in the Developing Spinal Cord. Journal of Comparative Neurology 2007, 503:297-307. |
| Kim D, Nguyen MD, Fischer A, Sananbenesi F, Dobbin MM, Rodgers JT, Delalle I, Baur JA, Sui G, Armour SM, Puigsrver P, Sinclair DA, Tsai L-H. SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer’s disease and amyotrophic lateral sclerosis. EMBO J 2007, 26: 3169-3179. |
Sananbenesi F, Fischer A, Schrick C, Neve R, Radulovic J, Tsai L-H. A Hippocampal Cdk5 Pathway Regulates Extinction of Contextual Fear. Nat Neurosci 2007, 10: 1012-1019. |
Ayala R, Shu T, Tsai L-H. Trekking across the brain: the journey of neuronal migration. Cell 2007; 128: 29-43. |
| Buchman JJ, Tsai L-H. Spindle regulation in neural precursors of flies and mammals. Nat Rev Neurosci; 2007: 89-100. |
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