Research Articles

| 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1999 | 1998 | 1997 | 1996 | 1995 |

Photoaffinity isolation and identification of proteins in cancer cell extracts that bind to platinum-modified DNA. Evan R. Guggenheim, Dong Xu, Christiana X. Zhang, Pamela V. Chang, and Stephen J. Lippard, ChemBioChem, 10, 141-157 (2009).

Small-Molecule Fluorescent Sensors for Investigating Zinc Metalloneurochemistry. Elizabeth M. Nolan, and Stephen J. Lippard, Acc. Chem. Res., 42, 193-203 (2009).

The state of the art of chemical biology. Karl-Heinz Altmann, Johannes Buchner, Horst Kessler, Francois Diederich, Bernhard Krautler, Stephen Lippard, Rob Liskamp, Klaus Muller, Elizabeth M. Nolan, Bruno Samori, Gisbert Schneider,Stuart L. Schreiber, Harald Schwalbe, Claudio Toniolo, Constant A. A. van Boeckel, Herbert Waldmann, and Christopher T. Walsh, ChemBioChem, 10, 16-29 (2009).

New Strategy for Quantifying Biological Zinc by a Modified Zinpyr Fluorescence Sensor. Xiao-an Zhang, Dugan Hayes, Sarah J. Smith, Simone Friedle, and Stephen J. Lippard, J. Am. Chem. Soc., 130, 15788-15789 (2008).

Organelle-Specific Zinc Detection Using Zinpyr-Labeled Fusion Proteins in Live Cells. Elisa Tomat, Elizabeth M. Nolan, Jacek Jaworski, and Stephen J. Lippard, J. Am. Chem. Soc., 130, 15776-15777 (2008).

Synthesis and Characterization of {Ni(NO)}10 and {Co(NO)2}10 Complexes Supported by Thiolate Ligands. Andrew G. Tennyson, Shanta Dhar, and Stephen J. Lippard, J. Am. Chem. Soc., 130, 15087-15098 (2008).

Tools and Tactics for the Optical Detection of Mercuric Ion. Elizabeth M. Nolan, and Stephen J. Lippard, Chem. Rev., 108, 3443-3480 (2008).

Reactions of Synthetic [2Fe-2S] and [4Fe-4S] Clusters with Nitric Oxide and Nitrosothiols. Todd C. Harrop, Zachary J. Tonzetich, Erwin Reisner, and Stephen J. Lippard, J. Am. Chem. Soc., 130, 15602-15610 (2008).

Bacterial nitric-oxide synthases operate without a dedicated redox partner. [Erratum to document cited in CA149:047515]. Ivan Gusarov, Marina Starodubtseva, Zhi-Qiang Wang, Lindsey McQuade, Stephen J. Lippard, Dennis J. Stuehr, and Evgeny Nudler, J. Biol. Chem., 283, 19164 (2008).

Poly(ADP-ribose) polymerase-1 activity facilitates the dissociation of nuclear proteins from platinum-modified DNA. Evan R. Guggenheim, Alison E. Ondrus, Mohammad Movassaghi, and Stephen J. Lippard, Bioorg. Med. Chem., 16, 10121-10128 (2008).

Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA-PEG nanoparticles. Shanta Dhar, Frank X. Gu, Robert Langer, Omid C. Farokhzad, and Stephen J. Lippard, Proc. Natl. Acad. Sci. U. S. A., 105, 17356-17361 (2008).

9-Triptycenecarboxylate-bridged diiron(II) complexes: Capture of the paddlewheel geometric isomer. Simone Friedle, Jeremy J. Kodanko, Kyrstin L. Fornace, and Stephen J. Lippard, J. Mol. Struct., 890, 317-327 (2008).

Targeted Single-Wall Carbon Nanotube-Mediated Pt(IV) Prodrug Delivery Using Folate as a Homing Device. Shanta Dhar, Zhuang Liu, Jurgen Thomale, Hongjie Dai, and Stephen J. Lippard, J. Am. Chem. Soc., 130, 11467-11476 (2008).

Bacterial Nitric-oxide Synthases Operate without a Dedicated Redox Partner. Ivan Gusarov, Marina Starodubtseva, Zhi-Qiang Wang, Lindsey McQuade, Stephen J. Lippard, Dennis J. Stuehr, and Evgeny Nudler, J. Biol. Chem., 283, 13140-13147 (2008).

Synthesis and characterization of a ditriflate-bridged, diiron(II) complex with syn-N-donor ligands: [Fe2(micro -OTf)2(PIC2DET)2](BARF)2. Jeremy J. Kodanko, and Stephen J. Lippard, Inorg. Chim. Acta, 361, 894-900 (2008).

cis-diammine(pyridine)chloroplatinum(II), a monofunctional platinum(II) antitumor agent: uptake, structure, function, and prospects. Katherine S. Lovejoy, Ryan C. Todd, Shuzhong Zhang, Michael S. McCormick, J. Alejandro D'Aquino, Joyce T. Reardon, Aziz Sancar, Kathleen M. Giacomini, and Stephen J. Lippard, Proc. Natl. Acad. Sci. U. S. A., 105, 8902-8907 (2008).

Conjugated Platinum(IV)-Peptide Complexes for Targeting Angiogenic Tumor Vasculature. Sumitra Mukhopadhyay, Carmen M. Barnes, Ariel Haskel, Sarah M. Short, Katie R. Barnes, and Stephen J. Lippard, Bioconjugate Chem., 19, 39-49 (2008).

A 1,2-d(GpG) Cisplatin Intrastrand Cross-Link Influences the Rotational and Translational Setting of DNA in Nucleosomes. Matthias Ober, and Stephen J. Lippard, J. Am. Chem. Soc., 130, 2851-2861 (2008).

Synthesis of dicarboxylate "C-clamp" 1,2-diethynylarene compounds as potential transition-metal ion hosts. Erwin Reisner, and Stephen J. Lippard, Eur. J. Org. Chem., 156-163 (2008).

Bacillus anthracis-derived nitric oxide is essential for pathogen virulence and survival in macrophages. Konstantin Shatalin, Ivan Gusarov, Ekaterina Avetissova, Yelena Shatalina, Linsey E. McQuade, Stephen J. Lippard, and Evgeny Nudler, Proc. Natl. Acad. Sci. U. S. A., 105, 1009-1013 (2008).

A Reversible pH-Dependent Intramolecular Pyridine-Aldehyde Cyclization. Xiao-an Zhang, Datong Song, and Stephen J. Lippard, J. Org. Chem., 73, 734-737 (2008).

Iron Complexes of Dendrimer-Appended Carboxylates for Activating Dioxygen and Oxidizing Hydrocarbons. Min Zhao, Brett Helms, Elena Slonkina, Simone Friedle, Dongwhan Lee, Jennifer DuBois, Britt Hedman, Keith O. Hodgson, Jean M. J. Frechet, and Stephen J. Lippard, J. Am. Chem. Soc., 130, 4352-4363 (2008).

Dioxygen Activation at Non-Heme Diiron Centers: Oxidation of a Proximal Residue in the I100W Variant of Toluene/o-Xylene Monooxygenase Hydroxylase. Leslie J. Murray, Sunil Naik, Michael S. McCormick, Roman Davidov, Ricard Garcia-serres, Sun-Hee Kim, Brian M. Hoffman, Boi Hanh Huynh, Stephen J. Lippard, Biochemistry, 46, 14795-14809 (2007).

A Planar Carboxylate-Rich Tetrairon(II) Complex and its Conversion to Linear Triiron(II) and Paddlewheel Diiron(II) Complexes. Erwin Reisner, Joshua Telser, and Stephen J. Lippard, Inorg. Chem., 46, 10754-10770 (2007).

Characterization of the Arene-Oxidizing Intermediate in ToMOH as a Diiron(III) Species. Leslie J. Murray, Sunil G. Naik, Danilo O. Ortillo, Ricardo García-Serres, Jessica K. Lee, Boi Hanh Huynh, and Stephen J. Lippard, J. Am. Chem. Soc., 129, 14500-14510 (2007).

Influence of Steric Hindrance on the Core Geometry and Sulfoxidation Chemistry of Carboxylate-Rich Diiron(II) Complexes. Erwin Reisner, Tanya C. Abikoff and Stephen J. Lippard, Inorg. Chem., 46, 10229-10240 (2007).

Reactivity pathways for nitric oxide and nitrosonium with iron complexes in biologically relevant sulfur coordination spheres. Todd C. Harrop, Datong Song, Stephen J. Lippard, J. Inorg. Biochem., 101, 1730-1738 (2007).

Selective fluorescence detection of nitroxyl over nitric oxide in buffered aqueous solution using a conjugated netallopolymer. Andrew G. Tennyson, Loi Do, Rhett C. Smith and Stephen J. Lippard, Polyhedron, 26, 4625-4630 (2007).

Electronic Structure and FeNO Conformation of Nonheme Iron-Thiolate-NO Complexes: A Combined Experimental and DFT Study. Jeanet Conradie, Duncan A. Quarless, Jr., Hua-Fen Hsu, Todd C. Harrop, Stephen J. Lippard, Stephen A. Koch, Abhik Ghosh, J. Am. Chem. Soc., 129, 10446-10456 (2007).

Substrate Trafficking and Dioxygen Activation in Bacterial Multicomponent Monooxygenases. Leslie J. Murray and Stephen J. Lippard, Acc. Chem. Res., 40, 466-474 (2007).

Soluble Single-Walled Carbon Nanotubes as Longboat Delivery Systems for Platinum(IV) Anticancer Drug Design. Rodney P. Feazell, Nozomi Nakayama-Ratchford, Hongjie Dai, and Stephen J. Lippard. J. Am. Chem. Soc., 129, 8438-8439 (2007).

Synthesis, Structure, and Properties of a Mixed-Valent Triiron Complex of Tetramethyl Reductic Acid, an Ascorbic Acid Analog, and its Relationship to a Functional Non-Heme Iron Oxidation Catalyst System. YooJin Kim, Xudong Feng, and Stephen J. Lippard, Inorg. Chem., 46, 6099-6107 (2007).

Water-Soluble Porphyrins as a Dual-Function Molecular Imaging Platform for MRI and Fluorescence Zinc Sensing. Xiao-an Zhang, Katherine S. Lovejoy, Alan Jasanoff, Stephen J. Lippard, Proc. Natl. Acad. Sci. USA, 104, 10780-10785 (2007).

Direct Cellular Responses to Platinum-Induced DNA Damage. Yongwon Jung and Stephen J. Lippard, Chem. Rev., 107, 1387-1407 (2007).

Understanding the Effect of Carbonate Ion on Cisplatin Binding to DNA. Ryan C. Todd, Katherine S. Lovejoy, and Stephen J. Lippard, J. Am. Chem. Soc., 129, 6370-6371 (2007).

Cisplatin Damage Overrides the Predefined Rotational Setting of Positioned Nucleosomes. Matthias Ober and Stephen J. Lippard, J. Am. Chem. Soc., 129, 6278-6286 (2007).

Turn-On and Ratiometric Mercury Sensing in Water with a Red-Emitting Probe. Elizabeth M. Nolan and Stephen J. Lippard, J. Am. Chem. Soc., 129, 5910-5918 (2007).

Bifunctional Binding of Cisplatin to DNA: Why Does Cisplatin Form 1,2-Intrastrand Crosslinks with AG, But Not with GA? Yogita Mantri, Stephen J. Lippard and Mu-Hyun Baik, J. Am. Chem. Soc., 129, 5023-5030 (2007).

Intermediates in Dioxygen Activation by Methane monooxygenase: A QM/MM Study. David Rinaldo, Dean M. Philipp, Stephen J. Lippard, and Richard A. Friesner, J. Am. Chem. Soc., 129, 3135-3147 (2007).

Products from Enzyme-Catalyzed Oxidations of Norcarenes. Martin Newcomb, R. Esala, P. Chandrasena, Dharmika S. P. Lansakara-P., Hye-Yeong Kim, Stephen J. Lippard, Laurance G. Beauvais, Leslie J. Murray, Viviana Izzo, Paul F. Hollenberg, Minor J. Coon, J. Org. Chem., 72, 11128-1133 (2007).

Desaturase Reactions Complicate the Use of Norcarane as a Mechanistic Probe. Unraveling the Mixture of Twenty-Plus Products Formed in Enzyme-Catalyzed Oxidations of Norcarane. Martin Newcomb, R. Esala, P. Chandrasena, Dharmika S. P. Lansakara-P., Hye-Yeong Kim, Stephen J. Lippard, Laurance G. Beauvais, Leslie J. Murray, Viviana Izzo, Paul F. Hollenberg, Minor J. Coon, J. Org. Chem., 72, 1121-1127 (2007).

Metal-Based Turn-On Fluorescent Probes for Sensing Nitric Oxide. Mi Hee Lim and Stephen J. Lippard, Acct. Chem. Res., 40, 41-51 (2007).

X-Ray Structure of a Hydroxylase-Regulatory Protein Complex from a Hydrocarbon-Oxidizing Multicomponent Monooxygenase, Pseudomonas sp. OX1 Phenol Hydroxylase. Matthew H. Sazinsky, Pete W. Dunten, Michael S. McCormick, Alberto DiDonato, and Stephen J. Lippard, Biochemistry, 45, 15392-15404 (2006).

Zinspy Sensors with Enhanced Dynamic Range for Imaging Neuronal Cell Zinc Uptake and Mobilization. Elizabeth M. Nolan, Jubin W. Ryu, Jacek Jaworski, Rodney P. Feazell, Morgan Sheng, and Stephen J. Lippard, J. Am. Chem. Soc., 128, 15517-15528 (2006)

X-ray Crystal Structures of Manganese(II)-Reconstituted and Native Toluene/o-Xylene Monooxygenase Hydroxylase Reveal Rotamer Shifts in Conserved Residues and an Enhanced View of the Protein Interior. Michael S. McCormick, Matthew H. Sazinsky, Karen L. Condon, and Stephen J. Lippard, J. Am. Chem. Soc., 128, 15108-15110 (2006).

Mid-Range Affinity Fluorescent Zn(II) Sensors of the Zinpyr Family: Syntheses, Characterization and Biological Imaging Applications. Elizabeth M. Nolan, Jacek Jaworski, Maryann E. Racine, Morgan Sheng and Stephen J. Lippard, Inorg. Chem., 45, 9748-9757 (2006).

Conjugated Metallopolymers for Fluorescent Turn-On Detection of Nitric Oxide. Rhett C. Smith, Andrew G. Tennyson, Annie C. Won and Stephen J. Lippard, Inorg. Chem., 45, 9367-9373 (2006).

Luminescent Properties of Water-Soluble Conjugated Metallopolymers and their Application to Fluorescent Nitric Oxide Detection. Loi Do, Rhett C. Smith, Andrew G. Tennyson, and Stephen J. Lippard, Inorg. Chem., 45, 8998-9005 (2006).

Fluorescent Nitric Oxide Detection by Copper Complexes Bearing Anthracenyl and Dansyl Fluorophore Ligands. Mi Hee Lim and Stephen J. Lippard, Inorg. Chem., 45, 8980-8989 (2006).

Direct Nitric Oxide Detection In Aqueous Solution by Copper(II) Fluorescein Complexes. Mi Hee Lim, Brian A. Wong, William H. Pitcock, Deepa Mokshagundum, Mu-Hyun Baik, and Stephen J. Lippard, J. Am. Chem. Soc., 128, 14364-14373 (2006).

The Inorganic Side of Chemical Biology. Stephen J. Lippard, Nat. Chem. Biol., 2, 504-507 (2006).

Characterization of the Particulate Methane Monooxygenase Metal Centers in Multiple Redox States by X-ray Absorption Spectroscopy. Raquel L. Lieberman, Kalyan C. Kondapalli, Deepak B. Shrestha, Amanda S. Hakemian, Stephen M. Smith, Joshua Telser, Jane Kuzelka, Rajeev Gupta, A. S. Borovik, Stephen J. Lippard,  Brian M. Hoffman,  Amy C. Rosenzweig,  and Timothy L. Stemmler, Inorg. Chem., 45, 8372-8381 (2006).

Nitric Oxide-Induced Fluorescence Enhancement by Displacement of Dansylated Ligands from Cobalt. Mi Hee Lim, Chaoyuan Kuang, and Stephen J. Lippard, ChemBioChem, 7, 1571-1576 (2006).

Organic Cation Transporters Are Determinants of Oxaliplatin Cytotoxicity. Shuzhong Zhang, Katherine Lovejoy, James E. Shima, Leah L. Lagpacan, Yan Shu, Anna Lapuk, Joe W. Gray, Xin Chen, Stephen J. Lippard, and Kathleen M. Giacomini, Cancer Research, 66, 8847-8857 (2006).

Correlating Structure with Function in Bacterial Multicomponent Monooxygenases and Related Diiron Proteins. Matthew H. Sazinsky and Stephen J. Lippard, Acct. Chem. Res., 39, 558-566 (2006).

Analogues of Zinpyr-1 Provide Insight into the Mechanism of Zinc Sensing. Christian R. Goldsmith and Stephen J. Lippard, Inorg. Chem., 45, 6474-6478 (2006).

Water Induces a Structural Conversion and Accelerates the Oxygenation of Carboxylate-Bridged Non-Heme Diiron Enzyme Synthetic Analogues. Min Zhao, Datong Song, and Stephen J. Lippard, Inorg. Chem., 45, 6323-6330 (2006).

Polymer-Bound Dirhodium Tetracarboxylate Films for Fluorescent Detection of Nitric Oxide. Rhett C. Smith, Andrew G. Tennyson, and Stephen J. Lippard, Inorg. Chem., 45, 6222-6226 (2006).

Mechanistic Studies of the Oxidative N-Dealkylation of a Substrate Tethered to Carboxylate-Bridged Diiron(II) Complexes, [Fe2(µ-O2CArTol)2(O2CArTol)2(N,N-Bn2en)2]. Sungho Yoon and Stephen J. Lippard, Inorg. Chem., 45, 5438-5446 (2006).

Visualization of Nitric Oxide in Living Cells by a Copper-Based Fluorescent Probe. Mi Hee Lim, Dong Xu and Stephen J. Lippard, Nat. Chem. Biol., 2, 375-380 (2006).

Dioxygen Activation at Non-Heme Diiron Centers: Characterization of Intermediates in a Mutant Form of Toluene/o-Xylene Monooxygenase Hydroxylase. Leslie J. Murray, Ricardo García-Serres, Sunil Naik, Boi Hanh Huynh, and Stephen J. Lippard, J. Am. Chem. Soc., 128, 7458-7459 (2006).

Synthesis and Oxidation of Carboxylate-Bridged Diiron(II) Complexes with Substrates Tethered to Primary Alkyl Amine Ligands. Emily C. Carson and Stephen J. Lippard, J. Inorg. Biochem., 100, 1109-1117 (2006).

Zinc Metalloneurochemistry: Physiology, Pathology, Probes.  C. J. Chang and S. J. Lippard, Met. Ions Life Sci. 1, 321-370 (2006).

Interaction of Nitric Oxide with Tetrathiolato Iron(II) Complexes: Relevance to the Reaction Pathways of Iron Nitrosyls in Sulfur-Rich Biological Coordination Environments. Todd C. Harrop, Datong Song and Stephen J. Lippard, J. Am. Chem. Soc., 128, 3528-3529 (2006).

Selective Hg(II) Detection in Aqueous Solution with Thiol Derivatized Fluoresceins. Elizabeth M. Nolan, Maryann E. Racine, Stephen J. Lippard, Inorg. Chem., 45, 2742-2749 (2006).

Zinc-Secreting Paneth Cells Studied by ZP Fluorescence. Leonard J. Giblin, Christopher J. Chang, Anthony F. Bentley, Cathleen Frederickson, Stephen J. Lippard and Christopher J. Frederickson, J. Histochem. Cytochem., 54, 311-316 (2006).

RNA Polymerase II Blockage by Cisplatin-Damaged DNA: Stability and Polyubiquitylation of Stalled Polymerase. Yongwon Jung and Stephen J. Lippard, J. Biol. Chem., 281, 1361-1370 (2006).

Selective Labeling of Extracellular Proteins Containing Polyhistidine Sequences by a Fluorescein-Nitrilotriacetic Acid Conjugate. Christian R. Goldsmith, Jacek Jaworski, Morgan Sheng, Stephen J. Lippard, J.Am. Chem. Soc., 128, 418-419 (2006).

Dioxygen-Initiated Oxidation of Heteroatomic Substrates Incorporated 
into Ancillary Pyridine Ligands of Carboxylate-Rich Diiron(II) Complexes. Emily C. Carson and Stephen J. Lippard, Inorg. Chem., 45, 837-848 (2006).

Synthesis, Characterization, and Preliminary Oxygenation Studies of Benzyl- and Ethyl-Substituted Pyridine Ligands of Carboxylate-Rich Diiron(II) Complexes. Emily C. Carson and Stephen J. Lippard, Inorg. Chem., 45, 828-836 (2006).

6-Methylpyridyl for Pyridyl Substitution Tunes the Properties of Fluorescent Zinc Sensors of the Zinpyr Family. Christian R. Goldsmith and Stephen J. Lippard, Inorg. Chem., 45, 555-561 (2006).

Structural Aspects of Pt-DNA Adduct Recognition by Proteins (Protein recognition of Pt-DNA Cross-links). Uta-Maria Ohndorf and Stephen J. Lippard, DNA Damage Recognition, W. Siede, Y. W. Kow, P. W. Doetsch, Eds. 12 , 239-261 (2005).

Intermolecular Electron-Transfer Reactions in Soluble Methane Monooxygenase: A Role for Hysteresis in Protein Function. Jessica L. Blazyk, George T. Gassner, and Stephen J. Lippard, J. Am. Chem. Soc., 127, 17364-17376 (2005).

QZ1 and QZ2: Rapid, Reversible Quinoline-Derivatized Fluoresceins for Sensing Biological Zn(II). Elizabeth M. Nolan, Jacek Jaworski, Ken-Ichi Okamoto, Yasunori Hayashi, Morgan Sheng and Stephen J. Lippard, J. Am. Chem. Soc., 127 , 16812-16823 (2005).

Iron Substitution for Sodium in a Carboxylate-Bridged, Heterodinuclear Sodium-Iron Complex. Jeremy J. Kodanko, Dong Xu, and Stephen J. Lippard, J. Am. Chem. Soc., 127, 16004-16005 (2005).

Reactions of the diiron(IV) intermediate Q in soluble methane monooxygenase with fluoromethanes. Laurance G. Beauvais and Stephen J. Lippard, Biochem. Biophys. Res. Commun. , 338 , 262-266 (2005).

Conjugated Polymer-Based Fluorescence Turn-On Sensor for Nitric Oxide. Rhett C. Smith, Andrew G. Tennyson, Mi Hee Lim and Stephen J. Lippard, Org. Lett. , 7 , 3573-3575 (2005).

Metal Ion Chemistry for Sustaining Life. Stephen J. Lippard, Medicinal Inorganic Chemistry, Jonathan L. Sessler, Susan R. Doctrow, Thomas J. McMurry, and Stephen J. Lippard, Eds.,  ACS Symp. Ser. 903, 1-4 (2005).

Copper Complexes for Fluorescence-Based NO Detection in Aqueous Solution. Mi Hee Lim and Stephen J. Lippard, J. Am. Chem. Soc. , 127 , 12170-12171 (2005).

Platinum anticancer drug damage enforces a particular rotational setting of DNA in nucleosomes. Andrew Danford, Dong Wang, Qun Wang, Thomas D. Tullius, and Stephen J. Lippard, Proc. Natl. Acad. Sci., USA, 102, 12311-12316 (2005).

MS4, a seminaphthofluoroscein-based chemosensor for the ratiometric detection of Hg(II). Elizabeth M. Nolan and Stephen J. Lippard, J. Mat. Chem., 15, 2778-2783 (2005).

Fluorescence-Based Nitric Oxide Detection, In Topics in Fluorescence Spectroscopy ; Scott A. Hilderbrand, Mi Hee Lim, and Stephen J. Lippard, Ed. Geddes, C. D., Lakowicz, J. R., Eds.; Springer, 2005; Vol. 9, 163-180 .

Esterase-Activated Two-Fluorophore System for Ratiometric Sensing of Biological Zinc(II). Carolyn C. Woodroofe, Annie C. Won, and Stephen J. Lippard, Inorg. Chem., 44, 3112-3120 (2005).

X-Ray Absorption Spectroscopic Study of the Reduced Hydroxylases of Methane Monooxygenase and Toluene/ o -Xylene Monooxygenase: Differences in Active Site Structure and Effects of the Coupling Proteins MMOB and ToMOD. Deanne Jackson Rudd, Matthew H. Sazinsky, Stephen J. Lippard, Britt Hedman, and Keith O. Hodgson, Inorg. Chem., 44, 4546-4554 (2005).

Water Affects the Stereochemistry and Dioxygen Reactivity of Carboxylate-Rich Diiron(II) Models for the Diiron Centers in Dioxygen-Dependent Non-Heme Enzymes. Sungho Yoon and Stephen J. Lippard, J. Am. Chem. Soc., 127, 8386-8397 (2005).

Hydroxylation of C-H bonds at carboxylate-bridged diiron centres. Stephen J. Lippard, Phil. Trans. R. Soc. A, 363, 861-877 (2005).

Reactions of the Peroxo Intermediate of Soluble Methane Monooxygenase Hydroxylase with Ethers. Laurance G. Beauvais and Stephen J. Lippard, J. Am. Chem. Soc., 127, 7370-7378 (2005).

Product Bound Structures of the Soluble Methane Monooxygenase Hydroxylase from Methylococcus capsulatus (Bath): Protein Motion in the a -Subunit. Matthew H. Sazinsky and Stephen J. Lippard, J. Am. Chem. Soc., 127, 5814-5825 (2005).

Fourier Transform Infrared Characterization of the Azido Complex of Methane Monooxygenase Hydroxylase from Methylococcus capsulatus (Bath). Shen Lu, Matthew H. Sazinsky, James W. Whittaker, Stephen J. Lippard, and Pierre Moënne-Loccoz, J. Am. Chem. Soc., 127, 4148-4149 (2005).

Cellular Processing of Platinum Anticancer Drugs. Dong Wang and Stephen J. Lippard, Nat. Rev. Drug. Disc., 4, 307-320 (2005)

Synthesis of isomerically pure carboxylate- and sulfonate-substituted xanthene fluorophores. Carolyn C. Woodroofe, Mi Hee Lim, Weiming Bu and Stephen J. Lippard, Tetrahedron, 61, 3097-3105 (2005).

Substrate Hydroxylation in Methane Monooxygenase: Quantitative Modeling via Mixed Quantum Mechanics/Molecular Mechanics Techniques. Benjamin F. Gherman, Stephen J. Lippard and Richard A. Friesner, J. Am. Chem. Soc., 127, 1025-1037 (2005).

Synthesis of a constrained ligand comprising carboxylate and amine donor groups via direct 1,8-functionalization of positionally protected fluorene. Dirk Burdinski, Karen Cheng and Stephen J. Lippard, Tetrahedron, 61, 1587-1594 (2005).

Membrane-Permeable and -Impermiable Sensors of the Zinpyr Family and Their Application to Imaging of Hippocampal Zinc in Vivo. Carolyn C. Woodroofe, Rafik Masalha, Katie R. Barnes, Christopher J. Frederickson and Stephen J. Lippard, Chem. & Biol., 11, 1659-1666 (2004).

Cobalt Chemistry with Mixed Aminotoponiminate Salicylaldiminate Ligands: Synthesis, Characterization, and Nitric Oxide Reactivity. Scott A. Hilderbrand and Stephen J. Lippard, Inorg. Chem. 43, 4674-4682 (2004).

Determination by X-Ray Absorption Spectroscopy of the Fe–Fe Separation in the Oxidized Form of the Hydroxylase of Methane Monooxygenase Alone and in the presence of MMOD. Deanne Jackson Rudd, Matthew H. Sazinsky, Maarten Merkx, Stephen J. Lippard, Britt Hedman and Keith O. Hodgson, Inorg. Chem., 43, 4579-4589 (2004).

Crystal Structure of the Toluene/o-Xylene Monooxygenase Hydroxylase from Pseudomonas stutzeri OX1. Matthew H. Sazinsky, Joel Bard, Alberto Di Donato and Stephen J. Lippard, J. Biol. Chem., 279, 30600-30610 (2004).

Identification of Nuclear Proteins that Interact with Platinum-Modified DNA by Photoaffinity Labeling. Christiana Xin Zhang, Pamela V. Chang and Stephen J. Lippard, J. Am. Chem. Soc., 126, 6536-6537 (2004).

Cisplatin-induced Post-Translational Modification of Histones H3 and H4. Dong Wang and Stephen J. Lippard, J. Biol. Chem., 279, 20622-20625 (2004).

Bioinorganic Chemistry. Jeremy M. Berg and Stephen J. Lippard, Curr. Op. Chem. Biol., 8, 160-161 (2004).

Synthesis, Characterization, and Cytotoxicity of a Series of Estrogen-Tethered Platinum(IV) Complexes. Katie R. Barnes, Alexander Kutikov, and Stephen J. Lippard, Chem. & Biol., 11, 557-564 (2004).

Dirhodium Tetracarboxylate Scaffolds as Reversible Fluorescence-Based Nitric Oxide Sensors. Scott A. Hilderbrand, Mi Hee Lim and Stephen J. Lippard, J. Am. Chem. Soc., 126, 4972-4978 (2004).

Synthesis and Characterization of Extracellular Zinc Sensors Based on a Monosubstituted Fluoroscein Platform. Elizabeth M. Nolan, Shawn C. Burdette, Jessica H. Harvey, Scott A. Hilderbrand and Stephen J. Lippard, Inorg. Chem., 43, 2624-2635 (2004).

Chapter 19: Cisplatin and Related Anticancer Drugs: Recent Advances and Insights. Katie R. Barnes and Stephen J. Lippard, Metal Ions in Biological Systems, 42, 143-177, (2004).

Oxidation of Sulfide, Phosphine, and Benzyl Substrates Tethered to N-Donor Ligands in Carboxylate-Bridged Diiron(II) Complexes. Emily C. Carson and Stephen J. Lippard, J. Am. Chem. Soc., 126, 3412-3413 (2004).

Synthesis and Characterization of Cu2(I,I), Cu2(I,II), and Cu2(II,II) Compounds Supported by Two Phthalazine-Based Ligands: Influence of a Hydrophobic Pocket. Jane Kuzelka, Sumitra Mukhopadhyay, Bernhard Spingler, and Stephen J. Lippard, Inorg. Chem., 43, 1751-1761 (2004).

Dioxygen Activation in Methane Monooxygenase: A Theoretical Study. Benjamin F. Gherman, Mu-Hyun Baik, Stephen J. Lippard and Richard A. Friesner, J. Am. Chem. Soc., 126, 2978-2990 (2004).

Synthesis and Characterization of Carboxylate-Rich Complexes Having the {Fe2(μ-OH)2(μ-O2CR)}3+ and {Fe2(μ-O)(μ-O2CR)}3+ Cores of O-2-Dependent Diiron Enzymes. Sungho Yoon and Stephen J. Lippard, J. Am. Chem. Soc., 126, 2666-2667 (2004).

Bright Fluorescent Chemosensor Platforms for Imaging Endogenous Pools of Neuronal Zinc. Christopher J. Chang, Elizabeth M. Nolan, Jacek Jaworski, Shawn C. Burdette, Morgan Sheng and Stephen J. Lippard, Chem. & Biol., 11, 203-210 (2004).

Synthetic Models for Non-Heme Carboxylate-Bridged Diiron Metalloproteins: Strategies and Tactics. Edit Y. Tshuva and Stephen J. Lippard, Chem. Rev., 104, 987-1012 (2004).

Domain Engineering of the Reductase Component of Soluble Methane Monooxygenase from Methylococcus capsulatus (Bath). Jessica L. Blazyk and Stephen J. Lippard, J. Biol. Chem., 279, 5630-5640 (2004).

A tautometric zinc sensor for ratiometric fluorescence imaging: Application to nitric oxide-induced release of intracellular zinc. Christopher J. Chang, Jacek Jaworski, Elizabeth M. Nolan, Morgan Sheng, and Stephen J. Lippard, Proc. Natl. Acad. Sci., 101, 1129-1134 (2004).

Modeling the Syn Disposition of Nitrogen Donors at the Active Sites of Carboxylate-Bridged Diiron Enzymes. Enforcing Dinuclearity and Kinetic Stability with a 1,2-Diethynylbenzne-Based Ligand. Jane Kuzelka, Joshua R. Farrell and Stephen J. Lippard, Inorg. Chem., 42, 8652-8662 (2003).

cis-{Pt(NH3)2(L)}2+/+ (L = Cl, H2O, NH3) Binding to Purines and CO: Does π−Backdonation Play a Role? Mu-Hyun Baik, Richard A. Friesner and Stephen J. Lippard, Inorg. Chem., 42, 8615-8617 (2003).

Synthesis, Characterization, and Dioxygen Reactivity of Tetracarboxylate-Bridged Diiron(II) Complexes with Coordinated Substrates. Sungho Yoon and Stephen J. Lippard, Inorg. Chem., 42, 8606-8608 (2003).

Multiple States of Stalled T7 RNA Polymerase at DNA Lesions Generated by Platinum Anticancer Agents. Yongwon Jung and Stephen J. Lippard, J. Biol. Chem., 278, 52084-52092 (2003).

Nonheme Diiron Enzymes. Dongwhan Lee and Stephen J. Lippard, Comprehensive Coordination Chemistry–II, 309-342 (2003).

A “Turn-On” Fluorescent Sensor for the Selective Detection of Mercuric Ion in Aqueous Media. Elizabeth M. Nolan and Stephen J. Lippard, J. Am. Chem. Soc., 125, 14270-14271 (2003).

Theoretical Study of Cisplatin Binding to Purine Bases: Why Does Cisplatin Prefer Guanine Over Adenine? Mu-Hyun Baik, Richard A. Friesner and Stephen J. Lippard, J. Am. Chem. Soc., 125, 14082-14092 (2003).

Modeling Features of the Non-Heme Diiron Cores in O2-Activating Enzymes through the Synthesis, Characterization, and Oxidation of 1,8-Naphthyridine-Based Complexes. Jane Kuzelka, Sumitra Mukhopadhyay, Bernhard Spingler, and Stephen J. Lippard, Inorg. Chem., 42, 6447-6457 (2003).

A Novel Two-Fluorophore Approach to Ratiometric Sensing of Zn2+. Carolyn C. Woodroofe and Stephen J. Lippard, J. Am. Chem. Soc., 125, 11458-11459 (2003).

Stopped-Flow Fourier-Transform Infrared Spectroscopy of Nitromethane Oxidation by the Diiron(IV) Intermediate of Methane Monooxygenase Mylrajan Muthusamy, Edna A. Ambundo, Simon J. George, Stephen J. Lippard, and Roger N. F. Thorneley, J. Am. Chem. Soc., 125, 11150-11151 (2003).

New Metal Complexes as Potential Therapeutics. Christiana Xin Zhang and Stephen J. Lippard, Curr. Op. In Chem. Biol., 7, 481-489 (2003).

Mechanistic Studies on the Hydroxylation of Methane by Methane Monooxygenase. Mu-Hyun Baik, Martin Newcomb, Richard A. Friesner, and Stephen J. Lippard, Chem. Rev., 103, 2385-2419 (2003).

Peripheral Heme Substituents the H-Atom Abstraction Chemistry in Cytochromes P450. Victor Guallar, Mu-Hyun Baik, Stephen J. Lippard, and Richard A. Friesner, Proc. Natl. Acad. Sci. USA, 100, 6998-7002 (2003).

Structural Features of Covalently Cross-linked Hydroxylase and Reductase Proteins of Soluble Methane Monooxygenase as Revealed by Mass Spectrometric Analysis. Daniel A. Kopp, Eric A. Berg, Catherine E. Costello, and Stephen J. Lippard, J. Biol. Chem., 278, 20939-20945 (2003).

Nucleotide Excision Repair from Site-Specifically Platinum-Modified Nucleosomes. Dong Wang, Ryujiro Hara, Gitanjali Singh, Aziz Sancar, and Stephen J. Lippard, Biochem., 42, 6747-6753 (2003).

Synthesis and Metal-Binding Properties of Chelating Fluorescein Derivatives. Matthew A. Clark, Kathryn Duffy, Jyoti Tibrewala, and Stephen J. Lippard, Organic Letters, 5, 2051-2054 (2003).

How iron-containing proteins control dioxygen chemistry: a detailed atomic level description via accurate quantum chemical and mixed quantum mechanics/molecular mechanics calculations. Richard A. Friesner, Mu-Hyun Baik, Victor Guallar, Benjamin F. Gherman, Maria Wirstam, Robert B. Murphy, and Stephen J. Lippard, Coord. Chem. Rev., 238-239, 267-290 (2003).

Meeting of the Minds: Metalloneurochemistry. Shawn C. Burdette, and Stephen J. Lippard, PNAS Perspectives, 100, 3605-3610 (2003).

Reversible Dioxygen Binding to Hemerythrin. Maria Wirstam, Richard Friesner, Stephen J. Lippard, J. Am. Chem. Soc., 125, 3980-3987 (2003).

Preparation of macrocyclic and 'C-clamp' dicarboxylate compounds. Joshua R. Farrell, Dylan Stiles, Weiming Bu and Stephen J. Lippard, Tetrahedron, 59, 2463-2469 (2003).

Nature of Full-Length HMGB1 Binding to Cisplatin-Modified DNA. Yongwon Jung and Stephen J. Lippard, Biochemistry, 42, 2664-2671 (2003).

Zinc-Bound Thiolate-Disulfide Exchange: A Strategy for Inhibiting Metallo-b-Lactamases. Heidi Boerzel, Margery Koeckert, Weiming Bu, Bernhard Spingler, and Stephen J. Lippard, Inorg. Chem., 42, 1604-1615 (2003).

ZP4, an Improved Neuronal Zn2+ Sensor of the Zinpyr Family. Shawn C. Burdette, Christopher J. Frederickson, Weiming Bu, and Stephen J. Lippard, J. Am. Chem. Soc., 1778-1787 (2003).

Cisplatin Sensitivity in Hmgb1-/- and Hmgb1+/+ Mouse Cells. Min Wei, Olga Burenkova, and Stephen J. Lippard, J. Biol. Chem., 277, 1769-1773 (2003).

2.4 Å Crystal Structure of the Asymmetric Platinum Complex {Pt(ammine)(cyclohexylamine)}2+ Bound to a Dodecamer DNA Duplex. Adam P. Silverman, Weiming Bu, Seth M. Cohen, and Stephen J. Lippard, J. Biol. Chem., 277, 49743-49749 (2002).

Expression and Characterization of Ferredoxin and Flavin Adenine Dinucleotide-Binding Domains of the Reductase Component of Soluble Methane Monooxygenase from Methylococcus capsulatus (Bath). Jessica Blazyk, and Stephen J. Lippard, Biochemistry, 41, 15780-15794 (2002).

The Rhodafluor Family. An Initial Study of Potential Ratiometric Fluorescent Sensors for Zn2+. Shawn C. Burdette and Stephen J. Lippard, Inorg. Chem., 41, 6816-6823 (2002).

Hydroxylation of Methane by Non-Heme Diiron Enzymes. A Molecular Orbital Analysis of C-H Bond Activation by Reactive Intermediate Q. Mu-Hyun Baik, Benjamin F. Gherman, Richard A. Friesner, and Stephen J. Lippard, J. Am. Chem. Soc., 124, 14608-14615 (2002).

Structural Flexibility within a Sterically Hindered Ligand Platform: Mononuclear Iron(II) Carboxylate Complexes as Subsite Models for Diiron(II) Centers. Donghwan Lee and Stephen J. Lippard, Inorg. Chim. Acta., 341, 1-11 (2002).

Component B Binding to the Soluble Methane Monooxygenase Hydroxylase by Saturation-Recovery EPR Spectroscopy of Spin-Labeled MMOB. Ryan MacArthur, Matthew H. Sazinsky, Henriette K?Douglas Whittington, Stephen J. Lippard, and Gary Brudvig, J. Am. Chem. Soc., 124, 13392-13393 (2002).

Carboxylate-Bridged Diiron(II) Complexes with a Sterically Hindered Phthalazine Ligand. Jane Kuzelka, Bernhard Spingler, Stephen J. Lippard, Inorg. Chim. Acta, 337, 212-222 (2002).

Soluble Methane Monooxygenase: Activation of Dioxygen and Methane. Daniel A. Kopp, and Stephen J. Lippard, Curr. Op. In. Chem. Biol., 6, 568-576, (2002).

The Testis-Specific HMG-Domain Protein Alters the Responses of Cells to Cisplatin. Deborah B. Zamble, Yuji Mikata, Christina H. Eng, Karen E. Sandman, and Stephen J. Lippard, J. Inorg. Biochem., 91, 451-462 (2002).

Theoretical Studies of Diiron(II) Complexes That Model Features of the Dioxygen-Activating Centers in Non-Heme Diiron Enzymes. Mu-Hyun Baik, Dongwhan Lee, Richard Friesner, and Stephen J. Lippard, Israel J. Chem., 41, 173-186 (2002).

Reactions of Methane Monooxygenase Intermediate Q with Derivatized Methanes. Edna A. Ambundo, Richard A. Friesner, and Stephen J. Lippard, J. Am. Chem. Soc., 124, 8770-8771 (2002).

Evaluation of Norcarane as a Probe for Radicals in Cytochrome P450- and Soluble Methane Monooxygenase-Catalyzed Hydroxylation Reactions. Martin Newcombe, Runnan Shen, Yun Lu, Minor J. Coon, Paul F. Hollenberg, Daniel A. Kopp, and Stephen J. Lippard, J. Am. Chem. Soc., 124, 6879-6886 (2002).

Structural and Spectroscopic Studies of Valence-Delocalized Diiron(II,III) Complexes Supported by Carboxylate-Only Bridging Ligands. Dongwhan Lee, Jennifer Dubois, Brad Pierce, Britt Hedman, Keith O. Hodgson, Michael P. Hendrich, and Stephen J. Lippard, Inorg. Chem., 41, 3172-3182 (2002).

Modeling Dioxygen-Activating Centers in Non-Heme Diiron Enzymes: Carboxylate Shifts in Diiron(II) Complexes Supported by Sterically Hindered Carboxylate Ligands. Dongwhan Lee, and Stephen J. Lippard, Inorg. Chem., 41, 2704-2719 (2002).

Synthesis and Structure of [Fe₁₃O₄F₂₄(OMe)₁₂]^5-: the First Open-Shell Keggin Ion. Avi Bino, Michael Ardon, Dongwhan Lee, Bernhard Spingler, and Stephen J. Lippard, J. Am. Chem. Soc., 124, 4578-4579 (2002).

Theoretical Study on the Stability of N-Glycosyl Bonds: Why Does N7-Platination not Promote Depurination? Mu-Hyun Baik, Richard A. Friesner, Stephen J. Lippard, J. Am. Chem. Soc., 124, 4495-4503 (2002).

Transcription-coupled ubiquitination of RNA polymerase II in vitro. Keng-Boon Lee, Dong Wang, Stephen J. Lippard, and Philip A. Sharp, Proc. Natl. Acad. Sci. USA, 99, 4239-4244, (2002).

Dynamics of Alkane Hydroxylation at the Non-heme Diiron Center in Methane Monooxygenase. Victor Guallar, Benjamin F. Gherman, William H. Miller, Stephen J. Lippard, and Richard A. Friesner, J. Am. Chem. Soc., 124, 3377-3384, (2002).

Quantum chemical studies of methane monooxygenase: comparision with P450. Victor Guallar, Benjamin F. Gherman, Stephen J. Lippard and Richard A. Friesner, Curr. Opin. Chem. Biol., 6, 236-242, (2002).

The Art of Chemistry. Stephen J. Lippard, Nature, 416, 587, (2002).

Functional Mimic of Dioxygen-Activating Centers in Non-Heme Diiron Enzymes: Mechanistic Implications of Paramagnetic Intermediates in the Reactions between Diiron(II) Complexes and Dioxygen. Dongwhan Lee, Brad Pierce, Carsten Krebs, Michael P. Hendrich, Boi Hanh Huynh, and Stephen J. Lippard, J. Am. Chem. Soc., 124, 3993-4007, (2002).

Product Binding to the Diiron(III) and Mixed-Valence Diiron Centers of Methane Monooxygenase Hydroxylase Studied by ^1,2H and ¹⁹F ENDOR Spectroscopy. Stoyan Smoukov, Daniel A. Kopp, Ann M. Valentine, Roman Davydov, Stephen J. Lippard and Brian M. Hoffman. J. Am. Chem. Soc., 124, 2657-2663, (2002).

Catalytic Oxygen Atom Transfer by a Carboxylate-Bridged Non-Heme Diiron Complex. Edit Y. Tshuva, Dongwhan Lee, Weiming Bu, Stephen J. Lippard, J. Am. Chem. Soc., 124, 2416-2417 (2002).

Synthetic Analogue of the {Fe₂(µ-OH)₂(µ-O₂CR)}³⁺ Core of Soluble Methane Monooxygenase Hydroxylase via Synthesis and Dioxygen Reactivity of Carboxylate-Bridged Diiron(II) Complexes. Dongwhan Lee, and Stephen J. Lippard, Inorg. Chem., 41, 827-837 (2002).

Why OrfY? Characterization of MMOD, a Long-Overlooked Component of the Soluble Methane Monooxygenase from Methylococcus capsulatus (Bath). Maarten Merkx, and Stephen J. Lippard. J. Biol. Chem., 277, 5858-5865 (2002).

Sterically Hindered Carboxylate Ligands Support Water-Bridged Dimetallic Centers That Model Features of Metallohydrolase Active Sites. Donghwan Lee, Pei-Lin Hung, Bernhard Spingler, and Stephen J. Lippard. Inorg. Chem., 41, 521-531, (2002).

NMR Structure of the [2Fe-2S] Ferredoxin Domain from Soluble Methane Monooxygenase Reductase and Interaction with its Hydroxylase. Jens Müller, Alexey A. Lugovskoy, Gerhard Wagner, and Stephen J. Lippard, Biochemistry, 41, 42-51 (2002).

Hydroxo-Bridged Cubane-Type Tetrairon(II) Clusters Supported by Sterically-Hindered Carboxylate Ligands. Dongwhan Lee, Lorenzo Sorace, Andrea Caneschi, and Stephen J. Lippard, Inorg. Chem., 40, 6774-6781 (2001).

Electron Transfer Reactions of the Reductase Component of Soluble Methane Monooxygenase from Methylococcus capsulatus (Bath). Daniel A. Kopp, George T. Gassner, Jessica L. Blazyk, and Stephen J. Lippard, Biochemistry, 40, 14932-14941 (2001).

Kinetic Studies of the TATA-binding Protein Interaction with Cisplatin-modified DNA. Yongwon Jung, Yuji Mikata, and Stephen J. Lippard, J. Biol. Chem., 276, 43589-43596 (2001).

Effects of Spectator Ligands on the Specific Recognition of Intrastrand Platinum DNA Cross-links by HMG box and TATA-binding Proteins. Min Wei, Seth M. Cohen, Adam P. Silverman, and Stephen J. Lippard, J. Biol. Chem., 276, 38774-38780 (2001).

2.4 A Crystal Structure of an Oxaliplatin 1,2-d(GpG) Intrastrand DNA Cross-link in a DNA Dodecamer Duplex. Bernhard Spingler, Douglas A. Whittington, and Stephen J. Lippard, Inorg. Chem., 40, 5596-5602 (2001).

Synthesis and Spectroscopic Studies of Non-Heme Diiron(III) Species with a Terminal Hydroperoxide Ligand: Models for Hemerythrin. Tadashi J. Mizoguchi, Jane Kuzelka, Bernhard Spingler, Jennifer Dubois, Roman M. Davydov, Britt Hedman, Keith O. Hodgson, and Stephen J. Lippard, Inorg. Chem., 40, 4662-4673 (2001).

Inter-chain hydrogen-bonding interactions may facilitate translocation of K⁺ ions across the potassium channel selectivity filter as suggested by synthetic modeling chemistry. Juan C. Mareque Rivas, Harald Schwalbe and Stephen J. Lippard, PNAS, 98, 9478-9483 (2001).

Fluorescent Sensors for Zn²⁺ Based on a Fluorescent Platform; Synthesis, Properties and Intracellular Distribution. Shawn C. Burdette, Grant K. Walkup, Bernhard Spingler, Roger Y. Tsien, and Stephen J. Lippard, J. Am. Chem. Soc., 123, 7831-7841 (2001).

Dioxygen Activation by Soluble Methane Monooxygenase: A Tale of Two Irons and Three Proteins. Maarten Merkx, Daniel A. Kopp, Matthew H. Sazinsky, Jessica L. Blazyk, Jens Müller, and Stephen J. Lippard, Angewandte Chemie Int Ed., 40, 2782-2807 (2001).

Cisplatin: Fron DNA Damage to Cancer Chemotherapy. Seth M. Cohen and Stephen J. Lippard, Progress in Nucleic Acids Research and Molecular Biology, 67, 93-130 (2001).

Trinuclear Zn(II) and Cu(II) Homo and Heterotrimetallic Complexes Involving D-Glucopyranosyl and Biscarboxylate Bridging Ligands. A Substrate Binding Model of Xylose Isomerases. Tomoaki Tanase, Hiromi Inukai, Tomoko Onaka, Merii Kato, Shigenobu Yano, and Stephen J. Lippard, Inorg. Chem., 40, 3943-3953 (2001).

Pentacoordinate Cobalt(III) Thiolate and Nitrosyl Tropocoronand Compounds. Katherine J. Franz, Linda H. Doerrer, Bernhard Spingler, and Stephen J. Lippard, Inorg. Chem., 40, 3774-3780 (2001).

Coordination Chemistry for the Neurosciences. Shawn C. Burdette and Stephen J. Lippard, Coord. Chem. Rev., 216-217, 333-361 (2001).

Intermediate in Beta-Lactam Hydrolysis catalyzed by a Dinuclear Zinc(II) Complex; Relevance to the Mechanism of the Metallo-Beta-Lactamase. Natalia V. Kaminskaia, Bernhard Spingler, and Stephen J. Lippard, J. Am. Chem. Soc., 123, 6555-6563 (2001).

Interaction of FACT, SSRP1, and the High Mobility Group (HMG) Domain of SSRP1 with DNA Damaged by the Anticancer Drug Cisplatin. Amanda Yarnell, Sangtaek Oh, Danny Reinberg, and Stephen J. Lippard, J. Biol. Chem., 276, 25736-25741 (2001).

Laser-Induced Photo-Cross-Linking of Cisplatin-Modified DNA to HMG-Domain Proteins. Yuji Mikata, Qing He, and Stephen J. Lippard, Biochem., 40, 7533-7541 (2001).

"Methane Monooxygenase Hydroxylase". Douglas A. Whittington and Stephen J. Lippard, Handbook of Metalloproteins, Albrecht Messerschmidt, Robert Huber, Thomas L. Poulos, and Karl Wieghardt (Eds.), John Wiley & Sons, Ltd., 712-724 (2001).

Oxidative N-Dealkylation of a Carboxylate-Bridged Diiron(II) Precursor Complex by Reaction with O₂ Affords the Elusive {Fe₂(mu-OH)₂(mu-O₂CR)}³⁺ Core of Soluble Methane Monooxygenase Hydroxylase. Dongwhan Lee, and Stephen J. Lippard, J. Am. Chem. Soc. , 123, 4611-4612 (2001).

Activation of the C-H Bond of Methane by Intermediate Q of Methane Monooxygenase: A Theoretical Study. Benjamin F. Gherman, Barry D. Dunietz, Douglas A. Whittington, Stephen J. Lippard, and Richard A. Friesner, J. Am. Chem. Soc., 123, 3836-3837 (2001).

A Short Copper-Copper Distance in a (mu-1,2-Peroxo)dicopper(II) Complex Having a 1,8-Naphthyridine Unit as an Additional Bridge. Chuan He, Jennifer L. Dubois, Britt Hedman, Keith O. Hodgson, and Stephen J. Lippard, Angew. Chem., 40, 1484-1487 (2001).

Synthesis and Electrochemical Studies of Diiron Complexes of 1,8-Naphthyridine-Based Dinucleating Ligands to Model Features of the Active Sites of Non-Heme Diiron Enzymes. Chuan He and Stephen J. Lippard, Inorg. Chem., 40, 1414-1420 (2001).

Xenon and Halogenated Alkanes Track Putative Substrate Binding cavities in the Soluble Methane Monooxygenase Hydroxylase. Douglas A. Whittington, Amy C. Rosenzweig, Christin A. Frederick, and Stephen J. Lippard, Biochemistry, 40, 3476-3482 (2001).

Decomposition of Alkyl-Substituted Urea Molecules at a Hydroxide-Bridged Dinickel Center. Amy M. Barrios and Stephen J. Lippard, Inorg. Chem., 40, 1250-1255 (2001).

Oxygen Kinetic Isotope Effects in Soluble Methane Monooxygenase. Shannon S. Stahl, Wilson A. Francisco, Maarten Merkx, Judith P. Klinman, and Stephen J. Lippard, J. Biol. Chem., 276, 4549-4553 (2001).

X-ray Crystal Structure of Alcohol Products Bound at the Active Site of Soluble Methane Monooxygenase Hydroxylase. Douglas A. Whittington, Matthew H. Sazinsky, and Stephen J. Lippard, J. Am. Chem. Soc., 123, 1794-1795 (2001).

Crystal Structure Determination of a (mu-Amido)(mu-hydroxo)(mu-superoxo)dicobalt(III) Complex from the Werner Collection. B. Spingler, M. Scanavy-Grigorieff, A. Werner, H. Berke and S.J. Lippard, Inorg. Chem., 40, 1065-1066 (2001).

Phthalazine-Based Dinucleating Ligands Afford Dinuclear Centers Often Encountered in Metalloenzyme Active Sites. A.M. Barrios and S. J. Lippard, Inorg. Chem., 40, 1060-1064 (2001).

Crystal Structures of the Soluble Methane Monooxygenase Hydroxylase from Methylococcus capsulatus (Bath) Demonstrating Geometric Variability at the Dinuclear Iron Active Site. D.A. Whittington and S.J. Lippard, J. Am. Chem. Soc., 123, 827-838 (2001).

Diiron Complexes of 1,8-Naphthyridine-Based Dinucleating Ligands as Models for Hemerythrin. C. He, A.M. Barrios, D. Lee, J. Kuzelka, R.M. Davydov, and S.J. Lippard, J. Am. Chem. Soc., 122, 12683-12690 (2000).

Intercalating Residues Determine the Mode of HMG1 Domains A and B Binding to Ciaplatin-Modified DNA. Q. He, U-M. Ohndorf, and S.J. Lippard, Biochemistry, 39, 14426-14435 (2000).

Synthesis and Characterization of Several Dicopper(I) Complexes and a Spin Delocalized Dicopper(I,II) Mixed-Valence Complex Using a 1,8-Napththyridine-Based Dinucleating Ligand. C. He and S.J. Lippard, Inorg. Chem., 39, 5225-5231 (2000).

Hidh-thoroughput synthesis and screening of platinum drug candidates. C.J. Ziegler, A.P. Silverman, and S. J. Lippard, J. Biol. Inorg. Chem., 5, 774-783 (2000).

Formation of cis-Diamminedichloroplatinum(II) 1,2-intrastrand cross-links on DNA is flanking sequence dependent. Judith N. Burstyn, Wendy J. Heiger-Bernays, Seth M. Cohen, and Stephen J. Lippard, Nucleic Acids Research, 28, 4237-4243 (2000).

Design and Synthesis of Multidentate Dinucleating Ligands Based on 1,8-Napththyridine. Chuan He and Stephen J. Lippard, Tetrahedron, 56, 8245-8252 (2000).

Mixed-Valent Heptairon Chloride Cluster Supported by the Porphyrin-Linked Dicarboxylate Ligand PDK. Xiao-Xiang Zhang and Stephen J. Lippard, Inorg. Chem., 39, 4388-4389 (2000).

Interaction of Urea with a Hydroxide-Bridged Dinuclear Nickel Center: An Alternative Model for the Mechanism of Urease. Amy M. Barrios and Stephen J. Lippard, J. Am. Chem. Soc., 122, 9172-9177 (2000).

Monodentate-Bridged Phosphodiester and Sulfate Complexes: Structural Insights into the Biological Activation of Phosphodiesters, Sulfate and Sulfate Esters. Chuan He, Victoria Gomez, Bernhard Spingler, and Stephen J. Lippard, Inorg. Chem., 39, 4188-4189 (2000).

HMG-Domain Protein Recognition of Cisplatin 1.2-Intrastrand d(GpG) Cross-Links in Purine-Rich Sequence Contexts. Seth M. Cohen, Yuji Mikata, Qing He, and Stephen J. Lippard, Biochemistry, 39, 11771-11776 (2000).

Aminotroponiminates as Ligands for Potential Metal_Based Nitric Oxide Sensors. Katherine J. Franz, Nisha Singh, Bernhard Spingler, and Stephen J. Lippard, Inorg. Chem., 39, 4081-4092 (2000).

Understanding the dioxygen reaction chemistry of diiron proteins through synthetic modeling studies. Justin Du Bois, Tadashi J. Mizoguchi, and Stephen J. Lippard, Coord. Chem. Reviews, 200, 443-485 (2000).

Synthesis of PDK, a Novel Porphyrin-Linked Dicarboxylate Ligand. Xiao Xiang Zhang and Stephen J. Lippard, J. Org. Chem., 65, 5298-5305 (2000).

The Quiet Revolution in Chemistry. Stephen J. Lippard, C&E News Perspective, 78, 64-65 (2000).

Nitrosyl Transfer from Manganese to Iron in Tropocoronand Complexes. Katherine J. Franz and Stephen J. Lippard, Inorg. Chem., 39, 3722-3723 (2000).

Reactivity of mu-Hydroxodizinc(II) Centers in Enzymatic Catalysis through Model Studies. Natalia V. Kaminskaia, Chuan He, and Stephen J. Lippard, Inorg. Chem., 39, 3365-3373 (2000).

Stopped-Flow Fluorescence Studies of HMG-Domain Protein Binding to Cisplatin-Modified DNA. Elizabeth R. Jamieson and Stephen J. Lippard, Biochemistry, 39, 8426-8438 (2000).

Enhanced Binding of the TATA-Binding Protein to TATA Boxes Containing Flanking Cisplatin 1,2-Cross-Links. Seth M. Cohen, Elizabeth R. Jamieson, and Stephen J. Lippard, Biochemistry, 39, 8259-8265 (2000).

Hydrolysis of Beta-Lactam Antibiotics Catalyzed by Dinuclear Zinc(II) Complexes: Functional Mimics of Metallo-Beta-lactamases. Natalia V. Kaminskaia, Bernhard Spingler, and Stephen J. Lippard, J. Am. Chem. Soc., 122, 6411-6422 (2000).

Metal-Based NO Sensing by Selective Ligand Dissociation. Katherine J. Franz, Nisha Singh, and Stephen J. Lippard, Angew. Chem. Int. Ed., 39, 2120-2122 (2000).

A New Cell-Permeable Fluorescent Probe for Zn²⁺. Grant K. Walkup, Shawn C. Burdette, Stephen J. Lippard, and Roger Y. Tsien, J. Am. Chem. Soc., 122, 5644-5645 (2000).

Sequencing and analysis of the Methylococcus capsulatus (Bath) soluble methane monooxygenase genes. David E. Coufal, Jessica L. Blazyk, Douglas A. Whittington, Wayne W. Wu, Amy C. Rosenzweig, and Stephen J. Lippard, Eur. J. Biochem., 267, 2174-2185 (2000).

Steroid hormones induce HMG1 overexpression and sensitize breast cancer cells to cisplatin and carboplatin. Qing He, Cynthia H. Liang, and Stephen J. Lippard, Proc. Natl. Acad. Sci. USA, 97, 5768-5772 (2000).

Valence-Delocalized Diiron(II,III) Cores Supported by Carboxylate-Only Bridging Ligands. Dongwhan Lee, Carsten Krebs, Boi Hanh Huynh, Michael P. Hendrich, and Stephen J. Lippard, J. Am. Chem. Soc., 122, 5000-5001 (2000).

Bio-inorganic Chemistry: Newly Charted Waters. Stephen J. Lippard and Jeremy M. Berg, Curr. Opin. Chem. Biol., 4, 137-139 (2000).

DNA Sequence Context Modulates the Impact of a Cisplatin 1,2-d(GpG) Intrastrand Cross-link on the Conformational and Thermodynamic Properties of Duplex DNA. Daniel S. Pilch, Shari U. Dunham, Elizabeth R. Jamieson, Stephen J. Lippard, and Kenneth J. Breslauer, J. Mol. Biol., 296, 803-812 (2000).

Large Scale ab initio Quantum Chemical Calculation of the Intermediates in the Soluble Methane Monooxygenase Catalytic Cycle. Barry D. Dunietz, Michael D. Beachy, Yixiang Cao, Douglas A. Whittington, Stephen J. Lippard, and Richard A. Friesner, J. Am. Chem. Soc., 122, 2828-2839 (2000).

Modeling Carboxylate-Bridged Dinuclear Active Sites in Metalloenzymes Using a Novel Naphthyridine-Based Dinucleating Ligand. Chuan He and Stephen J. Lippard, J. Am. Chem. Soc., 122, 184-185 (2000).

Cationic Species Can Be Produced in Soluble Methane Monooxygenase-Catalyzed Hydroxylation Reactions; Radical Intermediates Are Not Formed. Seung-Yong Choi, Philip E. Eaton, Daniel A. Kopp, Stephen J. Lippard, Martin Newcomb, and Runnan Shen, J. Am. Chem. Soc., 121, 12198-12199 (1999).

Synthesis of Unsymmetrical Diolate, Oxametallacyclopentene, Amido-Alkoxide and Thiolato-Alkoxide Complexes Using Dialkyl and Diaryl Titanium Aminotroponiminate Complexes: A Route to Unsymmetrical Vicinal Diols. Dietrich P. Steinhuebel and Stephen J. Lippard, J. Am. Chem. Soc., 121, 11762-11772 (1999).

Amide Hydrolysis Effected by a Hydroxo-Bridged Dinickel(II) Complex: Insights into the Mechanism of Urease. Amy M. Barrios and Stephen J. Lippard, J. Am. Chem. Soc., 121, 11751-11757 (1999).

Synthetic and Structural Studies of Titanium Aminotroponiminate Complexes. Dietrich P. Steinhuebel and Stephen J. Lippard, Inorg. Chem., 38, 6225-6233 (1999).

NO Disproportionation Reactivity of Fe Tropocoronand Complexes. Katherine J. Franz and Stephen J. Lippard, J. Am. Chem. Soc., 121, 10504-10512 (1999).

Identification by NMR Spectroscopy of Residues at Contact Surfaces in Large, Slowly Exchanging Macromolecular Complexes. Hiroshi Matsuo, Kylie J. Walters, Kenta Teruya, Takeyuki Tanaka, George T. Gassner, Stephen J. Lippard, Yoshimasa Kyogoku, and Gerhard Wagner, J. Am. Chem. Soc., 121, 9903-9904 (1999).

Formation of Fe(III)Fe(IV) Species from the Reaction between a Diiron(II) Complex and Dioxygen: Relevance to Ribonucleotide Reductase Intermediate X. Dongwhan Lee, J. Du Bois, Doros Petasis, Michael P. Hendrich, Carsten Krebs, Boi Hanh Huynh, and Stephen J. Lippard, J. Am. Chem. Soc., 121, 9893-9894 (1999).

Component Interactions in the Soluble Methane Monooxygenase System from Methylococcus capsulatus (Bath). George T. Gassner and Stephen J. Lippard, Biochemistry, 38, 12768-12785 (1999).

Synthesis and Characterization of (Aminotroponiminato)titanium(IV) Dialkyl Complexes: Control of Reactivity by Ligand Design. Dietrich P. Steinheubel and Stephen J. Lippard, Organometallics, 18, 3959-3961 (1999).

Toxicity of platinum(II) amino acid (N,O) complexes parallels their binding to DNA as measured in a new solid phase assay involving a fluorescent HMG1 protein construct readout. Christopher J. Ziegler, Karen E. Sandman, Cynthia H. Liang, and Stephen J. Lippard, J. Biol. Inorg. Chem., 4, 402-411 (1999).

Structural and Spectroscopic Comparisons between (mu-Oxo)- and (mu-Hydroxo)bis(mu-carboxylato)diiron(III) Complexes That Contain All-Oxygen-Donor Ligands. Tadashi J. Mizoguchi, Roman M. Davydov, and Stephen J. Lippard, Inorg. Chem., 38, 4098-4103 (1999).

Structure, Recognition, and Processing of Cisplatin-DNA Adducts. Elizabeth R. Jamieson and Stephen J. Lippard, Chem. Rev., 99, 2467-2498 (1999).

Rapid fluorescence-based reporter-gene assays to evaluate the cytotoxicity and antitumor drug potential of platinum complexes. Karen E. Sandman, Sudhakar S. Marla, Gregor Zlokarnik, and Stephen J. Lippard, Chemistry & Biology, 6, 541-551 (1999).

Methylation of Iron-Sulfur Complexes by Trimethyl Phosphate. Jonathan J. Wilker and Stephen J. Lippard, Inorg. Chem., 38, 3569-3574 (1999).

Structure of the Soluble Methane Monooxygenase Regulatory Protein B. Kylie J. Walters, George T. Gassner, Stephen J. Lippard, and Gerhard Wagner, Proc. Natl. Acad. Sci. USA, 96, 7877-7882 (1999).

Anticancer Activity of Cisplatin and Related Complexes. Andrew Gelasco and Stephen J. Lippard, Metallopharmaceuticals I: DNA Interactions, Topics in Biological Inorganic Chemistry, Michael J. Clarke and Peter J. Sadler (Eds.), Springer-Verlag: Heidelberg, Germany, Vol. 1, pp. 1-43 (1999).

Mutational and structural analyses of the regulatory protein B of soluble methane monooxygenase from Methylococcus capsulatus (Bath). Hans Brandstetter, Douglas A. Whittington, Stephen J. Lippard, and Christin A. Frederick, Chemistry & Biology, 6, 441-449 (1999).

Dioxygen and alkane activation by iron-containing enzymes. Shannon S. Stahl and Stephen J. Lippard in Iron Metabolism: Inorganic Biochemistry and Regulatory Mechanisms, Glória C. Ferreira, José J. G. Moura, and Ricardo Franco, (Eds.), Wiley-VCH Verlag: Weinheim, Germany, Chap. 18, pp. 303-321 (1999).

Basis for recognition of cisplatin-modified DNA by high-mobility-group proteins. Uta-Maria Ohndorf, Mark A. Rould, Qing He, Carl O. Pabo, and Stephen J. Lippard, Nature, 399, 708-712 (1999).

The Reactivity of Well Defined Diiron(III) Peroxo Complexes Toward Substrates: Addition to Electrophiles and Hydrocarbon Oxidation. Daniel D. LeCloux, Amy M. Barrios, and Stephen J. Lippard, Bioorg. Med. Chem., 7, 763-772 (1999).

Structural and Kinetic Studies of a Cisplatin-modified DNA Icosamer Binding to HMG1 Domain B. Elizabeth R. Jamieson, Matthew P. Jacobson, Carmen M. Barnes, Christine S. Chow, and Stephen J. Lippard, J. Biol. Chem., 274, 12346-12354 (1999).

Mechanistic Studies of the Reaction of Reduced Methane Monooxygenase Hydroxylase with Dioxygen and Substrates. Ann M. Valentine, Shannon S. Stahl, and Stephen J. Lippard, J. Am. Chem. Soc., 121, 3876-3887 (1999).

Free Copper Ions in the Cells? Stephen J. Lippard, Science, 284, 748-749, (1999).

Methods for Screening the Potential Antitumor Activity of Platinum Compounds in Combinatorial Libraries. Karen E. Sandman and Stephen J. Lippard in Cisplatin: Chemistry and Biochemistry of a Leading Anticancer Drug, Lippert, B. (Ed.), pp. 523-536, Wiley-VCH, Weinheim, Germany (1999).

The Response of Cellular Proteins to Cisplatin-Damaged DNA. , pp. 523-536, Wiley-VCH, Weinheim, Germany (1999).

The Response of Cellular Proteins to Cisplatin-Damaged DNA. Deborah B. Zamble and Stephen J. Lippard in Cisplatin: Chemistry and Biochemistry of a Leading Anticancer Drug, Lippert, B. (Ed.), pp. 73-110, Wiley-VCH, Weinheim, Germany (1999).

Oxidation of Ultrafast Radical Clock Substrate Probes by the Soluble Methane Monooxygenase from Methylococcus capsulatus (Bath). Ann M. Valentine, Marie-Helene LeTadic-Biadatti, Patrick H. Toy, Martin Newcomb, and Stephen J. Lippard, J. Biol. Chem., 274, 10771-10776 (1999).

Reactions of Nitric Oxide with the Reduced Non-Heme Diiron Center of the Soluble Methane Monooxygenase Hydroxylase. David E. Coufal, Pedro Tavares, Alice S. Pereira, Boi Hanh Huynh, and Stephen J. Lippard, Biochemistry, 38, 4504-4513 (1999).

An EPR Study of the Dinuclear Iron Site in the Soluble Methane Monooxygenase from Methylococcus capsulatus (Bath) Reduced by One Electron at 77 K: The Effects of Component Interactions and the Binding of Small Molecules to the Diiron(III) Center. Roman Davydov, Ann M. Valentine, Sonja Komar-Panicucci, Brian M. Hoffman, and Stephen J. Lippard, Biochemistry, 38, 4188-4197 (1999).

Synthesis of Unsymmetrical Vicinal Diols Using Titanium Aminotroponiminate Alkyl Complexes. Dietrich P. Steinhuebel and Stephen J. Lippard, Organometallics, 18, 109-111 (1999).

Single d(GpG)/cis-diammineplatinum(II) Adduct-Induced Inhibition of DNA Polymerization. Zucai Suo, Stephen J. Lippard, and Kenneth A. Johnson, Biochemistry, 38, 715-726 (1999).

Mixed-Valence CuI-CuII and Heterodimetallic CuI-MII Bis(carboxylate-bridged) Complexes: Structural, Electrochemical, and Spectroscopic Investigations. Daniel D. LeCloux, Roman Davydov, and Stephen J. Lippard, Inorg. Chem., 37, 6814-6826 (1998).

Structural and Functional Models of the Dioxygen-Activating Centers of Non-Heme Diiron Enzymes Ribonucleotide Reductase and Soluble Methane Monooxygenase. Dongwhan Lee and Stephen J. Lippard, J. Am. Chem. Soc., 120, 12153-12154 (1998).

Synthetic Models of the Deoxy and Oxy Forms of the Non-Heme Dioxygen-Binding Protein Hemerythrin. Tadashi J. Mizoguchi and Stephen J. Lippard, J. Am. Chem. Soc., 120, 11022-11023 (1998).

Synthesis and Triiron Complexes of PDK, a New Porphyrin-Linked Dicarboxylate Ligand. Xiao Xiang Zhang, Peter Fuhrmann, and Stephen J. Lippard, J. Am. Chem. Soc., 120, 10260-10261 (1998).

A Novel Nonairon(III) Citrate Complex: A "Ferric Triple-Decker." Avi Bino, Itzhak Shweky, Shmuel Cohen, Erika R. Bauminger, and Stephen J. Lippard, Inorg. Chem., 37, 5168-5172 (1998).

Small Molecule Binding to the Mixed-Valent Diiron Center of Methane Monooxygenase Hydroxylase from Methylococcus capsulatus (Bath) as Revealed by ENDOR Spectroscopy. Jean-Paul Willems, Ann M. Valentine, Ryszard Gurbiel, Stephen J. Lippard, and Brian M. Hoffman, J. Am. Chem. Soc., 120, 9410-9416 (1998).

Disproportionation of Nitric Oxide Promoted by a Mn Tropocoronand. Katherine J. Franz and Stephen J. Lippard, J. Am. Chem. Soc., 120, 9034-9040 (1998).

Modeling the Diiron Centers of Non-Heme Iron Enzymes. Preparation of Sterically Hindered Diiron(II) Tetracarboxylate Complexes and Their Reactions with Dioxygen. Daniel D. LeCloux, Amy M. Barrios, Tadashi J. Mizoguchi, and Stephen J. Lippard, J. Am. Chem. Soc., 120, 9001-9014 (1998).

Synthesis and Characterization of Spin-Delocalized Carboxylate-Bridged Cu(I)-Cu(II) Mixed-Valence Complexes Having Only Oxygen Donor Ligands. Daniel D. LeCloux, Roman Davydov, and Stephen J. Lippard, J. Am. Chem. Soc., 120, 6810-6811 (1998).

Amino Acid Side Chain Movements in the Active Site of the Hydroxylase Enzyme from Soluble Methane Monooxygenase. Douglas A. Whittington and Stephen J. Lippard in Spectroscopic Methods in Bioinorganic Chemistry, Edward I. Solomon and Keith O. Hodgson (Eds.), ACS Symposium Series, 692, American Chemical Society, Washington, D.C., Chap. 19, pp. 334-347 (1998).

NMR Solution Structure of a DNA Dodecamer Duplex Containing a cis-Diammineplatinum(II) d(GpG) Intrastrand Cross-Link, the Major Adduct of the Anticancer Drug Cisplatin. Andrew Gelasco and Stephen J. Lippard, Biochemistry, 37, 9230-9239 (1998).

Substrate binding and C-H bond activation in the soluble methane monooxygenase hydroxylase. Douglas A. Whittington, Ann M. Valentine, and Stephen J. Lippard, J. Biol. Inorg. Chem., 3, 307-313 (1998).

Solution Structure of a DNA Duplex Containing a Nitroxide Spin-Labeled Platinum d(GpG) Intrastrand Cross-Link Refined with NMR-Derived Long-Range Electron-Proton Distance Restraints. Shari U. Dunham, Stephen U. Dunham, Christopher J. Turner, and Stephen J. Lippard, J. Am. Chem. Soc., 120, 5395-5406 (1998).

p53-dependent and -independent responses to cisplatin in mouse testicular teratocarcinoma cells. Deborah B. Zamble, Tyler Jacks, and Stephen J. Lippard, Proc. Natl. Acad. Sci. USA, 95, 6163-6168 (1998).

Synthesis and Reactivity of Cationic Group 4 Tropocoronand Complexes. Michael J. Scott and Stephen J. Lippard, Organometallics, 17, 1769-1773 (1998).

Telomere loss in cells treated with cisplatin. Toru Ishibashi and Stephen J. Lippard, Proc. Natl. Acad. Sci., USA, 95, 4219-4223 (1998).

A Mechanism-Based, Solution-Phase Method for Screening Combinatorial Mixtures of Potential Platinum Anticancer Drugs. Karen E. Sandman, Peter Fuhrmann, and Stephen J. Lippard, J. Biol. Inorg. Chem., 3, 74-80 (1998).

Synthesis, characterization, and reactivity of organometallic Zr(IV) carboxylate complexes. Dietrich P. Steinhuebel, Peter Fuhrmann, and Stephen J. Lippard, Inorg. Chim. Acta, 270, 527-536 (1998).

Generation of a Mixed-Valent Fe(III)Fe(IV) Form of Intermediate Q in the Reaction Cycle of Soluble Methane Monooxygenase, an Analog of Intermediate X in Ribonucleotide Reductase R2 Assembly. Ann M. Valentine, Pedro Tavares, Alice S. Pereira, Roman Davydov, Carsten Krebs, Brian M. Hoffman, Dale E. Edmondson, Boi Hanh Huynh, and Stephen J. Lippard, J. Am. Chem. Soc., 120, 2190-2191 (1998).

Reactivity of the Coordinated h2-Ketone in the Tropocoronand Complex [Hf(TC-3,5)(_2-OC(CH2PH)2)]: N-C Coupling, C-C Coupling, and Insertion into the C-O Bond. Michael J. Scott and Stephen J. Lippard, Organometallics, 17, 466-474 (1998).

Aminoguanidinium Hydrolysis Effected by a Hydroxo-Bridged Dicobalt(II) Complex as a Functional Model for Arginase and Catalyzed by Mononuclear Cobalt(II) Complexes. Chuan He and Stephen J. Lippard, J. Am. Chem. Soc., 120, 105-113 (1998).

Human Testis-Determining Factor SRY Binds to the Major DNA Adduct of Cisplatin and a Putative Target Sequence with Comparable Affinities. Elizabeth E. Trimmer, Deborah B. Zamble, Stephen J. Lippard, and John M. Essigmann, Biochemistry, 37, 352-362 (1998).

Isocyanide Insertion Reactions with Organometallic Group 4 Tropocoronand Complexes: Formation of h2-Iminoacyl, Enediamido, h2-Imine, and m-Imido Products. Michael J. Scott and Stephen J. Lippard, Organometallics, 16, 5857-5868 (1997).

A Cyclic Octadecairon(III) Complex, the Molecular 18-Wheeler. Stephen P. Watton, Peter Fuhrmann, Laura E. Pence, Andrea Caneschi, Andrea Cornia, Gian Luca Abbati, and Stephen J. Lippard, Angewandte Chemie, 36, 2774-2776 (1997).

Binding of tsHMG, a Mouse Testis-Specific HMG-Domain Protein, to Cisplatin-DNA Adducts. Uta-Maria Ohndorf, Joyce P. Whitehead, Nalini L. Raju, and Stephen J. Lippard, Biochemistry, 36, 14807-14815 (1997).

Principles of Small Molecule Activation by Metalloenzymes as Exemplified by the Soluble Methane Monooxygenase from Methylococcus capsulatus (Bath). Ann M. Valentine and Stephen J. Lippard, J. Chem. Soc. Dalton Trans., 3925-3931 (1997).

Synthesis and characterization of Zr(IV) and Hf(IV) tropocoronand complexes. Michael J. Scott and Stephen J. Lippard, Inorg. Chim. Acta, 263, 287-299 (1997).

Crystal Structures of the Methane Monooxygenase Hydroxylase From Methylococcus capsulatus (Bath): Implications for Substrate Gating and Component Interactions. Amy C. Rosenzweig, Hans Brandstetter, Douglas A. Whittington, Pär Nordlund, Stephen J. Lippard, and Christin A. Frederick, Proteins, 29, 141-152 (1997).

(m-Oxo)bis(m-carboxylato)bis(2,2'-bipyridyl)bis(X)diiron(III) Complexes, X = NCS-, NCSe-, and N3-: Synthetic Models of Pseudohalide Derivatives of Carboxylate-Bridged Diiron Proteins. Tadashi J. Mizoguchi and Stephen J. Lippard, Inorg. Chem., 36, 4526-4533 (1997).

DNA Sequence Context and Protein Composition Modulate HMG-Domain Protein Recognition of Cisplatin-Modified DNA. Shari U. Dunham and Stephen J. Lippard, Biochemistry, 36, 11428-11436 (1997).

Synthesis and Characterization of a Novel Class of Dicopper(I) Bis(carboxylate)-Bridged Complexes. Dan D. LeCloux and Stephen J. Lippard, Inorg. Chem., 36, 4035-4046 (1997).

Tuning of Electronic Properties and Reactivity in Four-Coordinate Cobalt(III) Complexes by the Tetraazamacrocyclic Tropocoronand Ligand. Linda H. Doerrer, Maria T. Bautista, and Stephen J. Lippard, Inorg. Chem., 36, 3578-3579 (1997).

Differences in the Reactivity of [Ag(PBu₃)I]₄ and [Cu(PBu₃I]₄ in Promoting Conjugate Addition. R. Bryan Klassen and Stephen J. Lippard, Organometallics, 16, 3623-3627 (1997).

Zinc and Cadmium Tropocoronand Complexes: Effect of Metal Ion Radius on Macrocyclic Ligand Twist and Fold. Linda H. Doerrer and Stephen J. Lippard, Inorg. Chem., 36, 2554-2563 (1997).

Methyl Transfer to Mercury Thiolates: Effects of Coordination Number and Ligand Dissociation. Jonathan J. Wilker, Karen E. Wetterhahn, and Stephen J. Lippard, Inorg. Chem., 36, 2079-2083 (1997).

Coupling of Carbon Monoxide to Isocyanides and Enones Induced by Alkyl Zr(IV) and Hf(IV) Tropocoronand Complexes. Michael J. Scott and Stephen J. Lippard, J. Am. Chem. Soc., 119, 3411-3412 (1997).

Alkyl Transfer to Metal Thiolates: Kinetics, Active Species Identification, and Relevance to the DNA Methyl Phosphotriester Repair Center of Escherichia coli Ada. Jonathan J. Wilker and Stephen J. Lippard, Inorg. Chem., 36, 969-978 (1997).

Tritiated Chiral Alkanes as Substrates for Soluble Methane Monooxygenase from Methylococcus capsulatus (Bath): Probes for the Mechanism of Hydroxylation. A. M. Valentine, B. Wilkinson, K. E. Liu, S. Komar-Panicucci, N. D. Priestley, P. G. Williams, H. Morimoto, H. G. Floss, and S. J. Lippard, J. Am. Chem. Soc., 119, 1818-1827 (1997).

A Hexairon(III) Complex with Three Non-Planar h2-m4-Peroxo Ligands Bridging Two Basic Iron Acetate Units. I. Shweky, L. E. Pence, G. C. Papaefthymiou, R. Sessoli, J. W. Yun, A. Bino, and S. J. Lippard, J. Am. Chem. Soc., 119, 1037-1042 (1997).

Non-Kramers ESEEM of Integer-Spin Diferrous Carboxylate-Bridged Clusters in Proteins. B. E. Sturgeon, P. E. Doan, K. E. Liu, D. Burdi, W. H. Tong, J. M. Nocek, N. Gupta, J. Stubbe, D. M. Kurtz, Jr., S. J. Lippard, and B. M. Hoffman, J. Am. Chem. Soc., 119, 375-386 (1997).

Kinetic Studies of Reactions of Dioxygen with Carboxylate-Bridged Diiron(II) Complexes Leading to the Formation of (m-Oxo)diiron(III) Complexes. A. L. Feig, A. Masschelein, A. Bakac, and S. J. Lippard, J. Am. Chem. Soc., 119, 334-342 (1997).

Synthesis, Characterization, and Magnetic Studies of Two Novel Isostructural Pentanuclear Iron(II) Complexes. S. Herold and S. J. Lippard, Inorg. Chem., 36, 50-58 (1997).

Carboxylate-Bridged Diiron(II) Complexes: Synthesis, Characterization and O₂-Reactivity of Models for the Reduced Diiron Centers in Methane Monooxygenase and Ribonucleotide Reductase. S. Herold and S. J. Lippard, J. Am. Chem. Soc., 119, 145-156 (1997).

Cisplatin and Related Drugs, P. Pil and S. J. Lippard in Encyclopedia of Cancer, Bertino, J. R., Editor-in-Chief, Academic Press: San Diego, CA, Vol. 1, pp. 392-410 (1997).

Carboxylate- and Phosphate Ester-Bridged Dimagnesium(II), Dizinc(II) and Dicalcium(II) Complexes. Models for Intermediates in Biological Phosphate Ester Hydrolysis. J.W. Yun, T. Tanase, and S. J. Lippard, Inorg. Chem., 35, 7590-7600 (1996).

Crystal Structure of the Anticancer Drug Cisplatin Bound to Duplex DNA. P. M. Takahara, C. A. Frederick, and S. J. Lippard, J. Am. Chem. Soc., 118, 12309-12321 (1996).

A Carboxylate-Bridged Non-Heme Diiron Dinitrosyl Complex. A.L. Feig, M.T. Bautista, and S.J. Lippard, Inorg. Chem., 35, 6892-6898 (1996).

Cisplatin-DNA Structure and Function. S. J. Lippard, Helix, 5, 34-35 (1996).

Repair of Cisplatin-DNA Adducts by the Mammalian Excision Nuclease. D. B. Zamble, D. Mu, J. T. Reardon, A. Sancar, and S. J. Lippard, Biochemistry, 35, 10004-10013 (1996).

Influence of cisplatin intrastrand crosslinking on the conformation, thermal stability, and energetics of a 20-mer DNA duplex. N. Poklar, D. S. Pilch, S. J. Lippard, E. A. Redding, S. U. Dunham, and K. J. Breslauer, Proc. Natl. Acad. Sci. USA, 93, 7606-7611 (1996).

Regiochemical Variations in Reactions of Methylcubane with tert-Butoxyl Radical, Cytochrome P-450 Enzymes, and a Methane Monooxygenase System. S.-Y. Choi, P. E. Eaton, P. F. Hollenberg, K. E. Liu, S. J. Lippard, M. Newcomb, D. A. Putt, S. P. Upadhyaya, and Y. Xiong, J. Am. Chem. Soc., 118, 6547-6555 (1996).

Carboxylate Shifts in the Active Site of the Hydroxylase Component of Soluble Methane Monooxygenase from Methylococcus capsulatus (Bath). A. C. Rosenzweig, C. A. Frederick, and S. J. Lippard, in Microbial Growth on C1 Compounds: Proceedings of the 8th International Symposium, Lidstrom, M.E. and Tabita, F.R. (Eds), Kluwer Academic Publishers: Dordrecht, The Netherlands, pp. 141-149 (1996).

Zinc-Containing Carboxylate-Bridged Heterodimetallic Complexes and Their Reactions with Phosphodiester Ligands. T. Tanase, J. W. Yun and S. J. Lippard, Inorganic Chemistry, 35, 3585-3594 (1996).

Magnetic properties of dodecanuclear mixed valence iron clusters. A. Caneschi, A. Cornia, S. J. Lippard, G. C. Papaefthymiou, and R. Sessoli, Inorg. Chim. Acta, 243, 295-304 (1996).

Automated Solid-Phase Synthesis of Site-Specifically Platinated Oligodeoxyribonucleotides. R. Manchanda, S. U. Dunham and S. J. Lippard, J. Am. Chem. Soc., 118, 5144-5145 (1996).

Structure and Mössbauer Spectrum of a (m-1,2-Peroxo)bis(m-carboxylato)-diiron(III) Model for the Peroxo Intermediate in the Methane Monooxygenase Hydroxylase Reaction Cycle. K. Kim and S. J. Lippard, J. Am. Chem. Soc., 118, 4914-4915 (1996).

Binding of IxrBinding of Ixr1, a Yeast HMG-Domain Protein, to Cisplatin-DNA Adducts in Vitro and in Vivo. M. M. McA'Nulty, J. P. Whitehead, and S. J. Lippard, Biochemistry, 35, 6089-6099 (1996).

Synthesis, Structural Studies, and Magnetic Exchange Interactions in Low-Valent Manganese Alkoxide Cubes. L. E. Pence, A. Caneschi, and S. J. Lippard, Inorg. Chem., 35, 2069-3072 (1996).

Mechanistic Studies of the Formation and Decay of Diiron(III) Peroxo Complexes in the Reaction of Diiron(II) Precursors with Dioxygen. A. L. Feig, M. Becker, S. Schindler, R. van Eldik, and S. J. Lippard, Inorg. Chem., 35, 2590-2601 (1996).

Proteins That Bind to and Mediate the Biological Activity of Platinum Anticancer Drug-DNA Adducts. J. P. Whitehead and S. J. Lippard, in Metal Ions in Biological Systems, Sigel, H. and Sigel, A., Eds., Marcel Dekker, Inc.: New York, NY, Vol. 32, Chapter 20, 687-726 (1996).

Photoreactivity of Platinum(II) in Cisplatin-Modified DNA Affords Specific Cross-Links to HMG Domain Proteins. S. A. Kane and S. J. Lippard, Biochemistry, 35, 2180-2188 (1996).

The HMG-domain protein Ixr1 blocks excision repair of cisplatin-DNA adducts in yeast. M. M. McA'Nulty and S. J. Lippard, Mutation Research, 362, 75-86 (1996).

Investigation of the Dinuclear Fe Center of Methane Monooxygenase by Advanced Paramagnetic Resonance Techniques: On the Geometry of DMSO Binding. V. J. DeRose, K. E. Liu, S. J. Lippard, and B. M. Hoffman, J. Am. Chem. Soc., 118, 121-134 (1996).

Mutagenic and genotoxic effects of DNA adducts formed by the anticancer drug cis-diamminedichloroplatinum(II). K. J. Yarema, S. J. Lippard, and J. M. Essigmann, Nucleic Acids Research, 23, 4066-4072 (1995).

DNA Adducts of cis-Diamminedichloroplatinum(II) and Its Trans Isomer Inhibit RNA Polymerase II Differentially in Vivo. J. A. Mello, S. J. Lippard, and J. M. Essigmann, Biochemistry, 34, 14783-14791 (1995).

Synthesis, Tuning of the Stereochemistry, and Physical Properties of Cobalt(II) Tropocoronand Complexes. B. S. Jaynes, L. H. Doerrer, S. Liu, and S. J. Lippard, Inorg. Chem., 34, 5735-5744 (1995).

Long-Range Distance Constraints in Platinated Nucleotides: Structure Determination of the 5' Orientational Isomer of cis-[Pt(NH₃)(4-aminoTEMPO){d(GpG)}]+ from Combined Paramagnetic and Diamagnetic NMR Constraints with Molecular Modeling. S. U. Dunham and S. J. Lippard, J. Am. Chem. Soc., 117, 10702-10712 (1995).

Kinetic and Spectroscopic Characterization of Intermediates and Component Interactions in Reactions of Methane Monooxygenase from Methylococcus capsulatus (Bath). K. E. Liu, A. M. Valentine, D. Wang, B. H. Huynh, D. E. Edmondson, A. Salifoglou, and S. J. Lippard, J. Am. Chem. Soc., 117, 10174-10185 (1995).

Cisplatin and DNA Repair in Cancer Chemotherapy. D. B. Zamble and S. J. Lippard, TIBS, 20, 435-439 (October 1995).

Crystal structure of a double-stranded DNA containing the major adduct of the anticancer drug cisplatin. P. M. Takahara, A. C. Rosenzweig, C. A. Frederick, and S. J. Lippard, Nature, 377, 649-652 (October 19, 1995).

Surface and Electrostatic Contributions to DNA-Promoted Reactions of Platinum(II) Complexes with Short Oligonucleotides: A Kinetic Study. S. K. C. Elmroth and S. J. Lippard, Inorg. Chem, 34, 5234-5243 (1995).

Dimolybdenum(II) Calixarene Complexes: Synthesis, Structure, Raman Spectroscopy, and Bonding. J. A. Acho, T. Ren, J. W. Yun, and S.J. Lippard, Inorg. Chem., 34, 5226-5233 (1995).

Modeling Phenoxyl Radical Metalloenzyme Active Sites. D. P. Goldberg, and S. J. Lippard, in Advances in Chemistry, Thorp, H. H. and Pecoraro, V. L., Eds., American Chemical Society: Washington, D.C., Vol. 246, 61-81 (1995).

Studies of the Soluble Methane Monooxygenase Protein System: Structure, Component Interactions, and Hydroxylation Mechanism, K. E. Liu and S. J. Lippard, in Advances in Inorganic Chemistry, Sykes, A. G., Ed., Academic Press, Inc.: San Diego, CA, Vol. 42, 263-289 (1995).

Dinuclear Manganese(II) Complexes with the {Mn₂(m-carboxylato)₂}²⁺ Core and Their Transformation to (m-Oxo)bis(m-carboxylato)-dimanganese(III) Complexes. T. Tanase and S.J. Lippard, Inorg. Chem., 34, 4682-4690 (1995).

Modeling the DNA Methylphosphotriester Repair Site in Escherichia coli Ada. Why Zinc and Four Cysteines? J. J. Wilker and S. J. Lippard, J. Am. Chem. Soc., 117, 8682-8683 (1995).

Alkali Metal-Responsive Geometric and Spectral Changes in a Cobalt(II) Complex of a Constrained Dicarboxylate: A Carboxylate Shift-Mediated Metallochromoionophore. S. P. Watton, M. I. Davis, L. E. Pence, J. Rebek Jr., and S. J. Lippard, Inorg. Chim. Acta, 235, 195-204 (1995).

Mono- and Dinuclear Zinc Complexes of XDK, H2XDK = m-Xylenediamine Bis(Kemp's triacid imide), and Their Reaction with Phosphate Esters. T. Tanase, J. W. Yun, and S. J. Lippard, Inorg. Chem., 34, 4220-4229 (1995).

Geometry of the Soluble Methane Monooxygenase Catalytic Diiron Center in Two Oxidation States. A. C. Rosenzweig, P. Nordlund, P. M. Takahara, C. A. Frederick, and S. J. Lippard, Chemistry & Biology, 2, 409-418 (1995).

Consequences of HMG-Domain Protein Binding to Cisplatin-Modified DNA. M. M. McA'Nulty and S. J. Lippard, Nucleic Acids & Molecular Biology, Volume 9, Eckstein, F. and Lilley, D. M. J., Eds., Springer-Verlag: Berlin Heidelberg, Germany, pp. 264-284 (1995).

Carboxylate-Bridged Diiron(II) Complexes, Including a New Model for Reduced Methane Monooxygenase Hydroxylase and the R2 Protein of Ribonucleotide Reductase. S. Herold, L.E. Pence, and S.J. Lippard, J. Am. Chem. Soc., 117, 6134-6135 (1995).

A Decanuclear Manganese Cluster with Oxo and Halide Bridging Ligands: Magnetic Behavior of an S ? 12 System. D. P. Goldberg, A. Caneschi, C. D. Delfs, R. Sessoli, and S. J. Lippard, J. Am. Chem. Soc., 117, 5789-5800 (1995).

Ferromagnetic Versus Antiferromagnetic Exchange in Five Structurally Analogous Carboxylate-Bridged Trinuclear Ferrous Complexes. D. P. Goldberg, J. Telser, C. M. Bastos, and S. J. Lippard, Inorg. Chem., 34, 3011-3024 (1995).

At Last-the Crystal Structure of Urease. S. J. Lippard, Science Perspective 268, 996-997, 19 May 1995.

Reactions of Low Valent Group V Dicarbonyl Phosphine Complexes with Carbon-Based Electrophiles to Produce Metal Alkyl, Acyl, Carbyne, and Acetylene Complexes. B. S. Bronk, J. D. Protasiewicz, L. E. Pence, and S. J. Lippard, Organometallics, 14, 2177-2187 (1995).

Pentamethylcyclopentadienyl and Cyclopentadienyl Tantalum and Niobium Calixarene Compounds and Their Water and Acetonitrile Inclusion Complexes. J. A. Acho, L. H. Doerrer, and S. J. Lippard, Inorg. Chem., 34, 2542-2556 (1995).

X-ray Absorption Spectroscopy Studies of the Diiron Center in Methane Monooxygenase in the Presence of Substrate and the Coupling Protein of the Enzyme System. J. G. DeWitt, A. C. Rosenzweig, A. Salifoglou, B. Hedman, S. J. Lippard, and K. O. Hodgson, Inorg. Chem., 34, 2505-2515 (1995).

Characterization of a Diiron(III) Peroxo Intermediate in the Reaction Cycle of Methane Monooxygenase Hydroxylase from Methylococcus capsulatus (Bath). K. E. Liu, A. M. Valentine, D. Qiu, D. E. Edmondson, E. H. Appelman, T. G. Spiro, and S. J. Lippard, J. Am. Chem. Soc., 117, 4997-4998 (1995).

Carboxylate- and Phosphodiester-Bridged Dinuclear Magnesium(II) Complexes. J. W. Yun, T. Tanase, L. E. Pence, and S. J. Lippard, J. Am. Chem. Soc., 117, 4407-4408 (1995).

A (m-Oxo)bis(m-Carboxylato)diiron(III) Complex with a Tethered Phenoxyl Radical as a Model for the Active Site of the R2 Protein of Ribonucleotide Reductase. D. P. Goldberg, D. Koulougliotis, G. W. Brudvig, and S. J. Lippard, J. Am. Chem. Soc., 117, 3134-3144 (1995).

A Single HMG Domain in High-Mobility Group 1 Protein Binds to DNAs as Small as 20 Base Pairs Containing the Major Cisplatin Adduct. C. S. Chow, C. M. Barnes, and S. J. Lippard, Biochemistry, 34, 2956-2964 (1995).

Reductive Coupling of Group 5 Dicarbonyls to Disiloxyacetylene Complexes: Ring Formation and Effects of Increasing Steric Demands. B. S. Bronk, J. D. Protasiewicz, and S. J. Lippard, Organometallics, 14, 1385-1392 (1995).

A Cyclic Hexairon(III) Complex with an Octahedrally Coordinated Sodium Ion at the Center, an Example of the [12]Metallacrown-6 Structure Type. A. Caneschi, A. Cornia, and S. J. Lippard, Angew. Chemie Int. Ed. Engl., 34, 467-469 (1995).

Calixarene Complexes of the Molybdenum-Molybdenum Quadruple Bond. J. A. Acho and S. J. Lippard, Inorg. Chim. Acta, 229, 5-8 (1995).

Platinum Anticancer Drugs. S. J. Lippard, NATO ASI Series Bioinorganic Chemistry: An Inorganic Perspective of Life, D. P. Kessissoglou, (Ed.), Kluwer Academic Publishers: The Netherlands, pp. 131-140 (1995).

Methane Monooxygenase. S. J. Lippard, NATO ASI Series Bioinorganic Chemistry: An Inorganic Perspective of Life, D. P. Kessissoglou, (Ed.), Kluwer Academic Publishers: The Netherlands, pp. 1-12 (1995).