Massachusetts Institute of Technology Massachusetts Institute of Technology
Department of Chemical Engineering
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Publications (2007 - 2013)

Adalsteinsson, V., Tahirova, N., Tallapragada, N., Yao, X., Campion, L., Angelini, A., Douce, T. B., Huang, C., Bowman, B., Williamson, C., Kwon, D. S., Wittrup, K. D. & Love, J. C. Single cells from human primary colorectal tumors exhibit polyfunctional heterogeneity in secretions of ELR+ CXC chemokines. Integr Biol (Camb)
doi: 10.1039/C3IB40059J (2013).

Reuel, N. F., Grassbaugh, B., Kruss, S., Mundy, J. Z., Opel, C., Ogunniyi, A. O., Egodage, K., Wahl, R., Helk, B., Zhang, J., Kalcioglu, Z. I., Tvrdy, K., Bellisario, D. O., Mu, B., Blake, S. S., Van Vliet, K. J., Love, J. C., Wittrup, K. D. & Strano, M. S. Emergent Properties of Nanosensor Arrays: Applications for Monitoring IgG Affinity Distributions, Weakly Affined Hypermannosylation, and Colony Selection for Biomanufacturing. ACS Nano, doi:10.1021/nn403215e (2013).

Nguyen, C. Q., Ogunniyi, A. O., Karabiyik, A. & Love, J. C. Single-cell analysis reveals isotype-specific autoreactive B cell repertoires in Sjogren's syndrome. PLoS One 8, e58127, doi:10.1371/journal.pone.0058127 (2013).

Love, K. R., Bagh, S., Choi, J. & Love, J. C. Microtools for single-cell analysis in biopharmaceutical development and manufacturing. Trends Biotechnol 31, 280-286, doi:10.1016/j.tibtech.2013.03.001 (2013).

Torres, A. J., Contento, R. L., Gordo, S., Wucherpfennig, K. W. & Love, J. C. Functional single-cell analysis of T-cell activation by supported lipid bilayer-tethered ligands on arrays of nanowells. Lab Chip 13, 90-99, doi:10.1039/c2lc40869d (2013).

Yamanaka, Y. J., Szeto, G. L., Gierahn, T. M., Forcier, T. L., Benedict, K. F., Brefo, M. S., Lauffenburger, D. A., Irvine, D. J. & Love, J. C. Cellular barcodes for efficiently profiling single-cell secretory responses by microengraving. Anal Chem 84, 10531-10536, doi:10.1021/ac302264q (2012).

Yamanaka, Y. J., Gierahn, T. M. & Love, J. C. The dynamic lives of T cells: new approaches and themes. Trends Immunol., doi:10.1016/ (2012).

Yamanaka, Y. J., Berger, C. T., Sips, M., Cheney, P. C., Alter, G. & Love, J. C. Single-cell analysis of the dynamics and functional outcomes of interactions between human natural killer cells and target cells. Integr Biol (Camb) 4, 1175-1184, doi:10.1039/c2ib20167d (2012).

Yalcin, A., Yamanaka, Y. J. & Love, J. C. Analytical technologies for integrated single-cell analysis of human immune responses. Methods Mol Biol 853, 211-235, doi:10.1007/978-1-61779-567-1_16 (2012).

Love, K. R., Politano, T. J., Panagiotou, V., Jiang, B., Stadheim, T. A. & Love, J. C. Systematic single-cell analysis of Pichia pastoris reveals secretory capacity limits productivity. PLoS One 7, e37915, doi:10.1371/journal.pone.0037915 (2012).

Varadarajan, N., Kwon, D. S., Law, K. M., Ogunniyi, A. O., Anahtar, M. N., Richter, J. M., Walker, B. D. & Love, J. C. Rapid, efficient functional characterization and recovery of HIV-specific human CD8+ T cells using microengraving. Proc. Natl. Acad. Sci. USA (2012).

Han, Q., Bagheri, N., Bradshaw, E. M., Hafler, D. A., Lauffenburger, D. A. & Love, J. C. Polyfunctional responses by human T cells result from sequential release of cytokines. Proc. Natl. Acad. Sci. USA 109, 1605-1612, doi:10.1073/pnas.1117194109 (2012).
(See also accompanying commentary:  Haining, W.N., Travels in time:  Assessing the functional complexity of T cells. Proc. Natl. Acad. Sci. USA 109, 1359-1360, doi:10.1073/pnas.1119856109 (2012).)

Varadarajan, N., Julg, B., Yamanaka, Y. J., Chen, H., Ogunniyi, A. O., McAndrew, E., Porter, L. C., Piechocka-Trocha, A., Hill, B. J., Douek, D. C., Pereyra, F., Walker, B. D. & Love, J. C. A high-throughput single-cell analysis of human CD8 T cell functions reveals discordance for cytokine secretion and cytolysis. J. Clin. Invest. 121, 4322-4331, doi:10.1172/JCI58653 (2011).

Zhao, W., Schafer, S., Choi, J., Yamanaka, Y. J., Lombardi, M. L., Bose, S., Carlson, A. L., Phillips, J. A., Teo, W., Droujinine, I. A., Cui, C. H., Jain, R. K., Lammerding, J., Love, J. C., Lin, C. P., Sarkar, D., Karnik, R. & Karp, J. M. Cell-surface sensors for real-time probing of cellular environments. Nat. Nanotechnol. 6, 524-531, doi:10.1038/nnano.2011.101 (2011).

Choi, J., Love, K. R., Gong, Y., Gierahn, T. M. & Love, J. C. Immuno-hybridization chain reaction for enhancing detection of individual cytokine-secreting human peripheral mononuclear cells. Anal. Chem. 83, 6890-6895, doi:10.1021/ac2013916 (2011).

Panagiotou, V., Love, K. R., Jiang, B., Nett, J., Stadheim, T. & Love, J. C. Generation and screening of Pichia pastoris strains with enhanced protein production by use of microengraving. Appl. Environ. Microb. 77, 3154-3156, doi:10.1128/AEM.00104-11 (2011).

Love, J. C. Making antibodies from scratch. Nat. Biotechnol. 28, 1176-1178, doi:10.1038/nbt1110-1176 (2010).

Love, J.C. Integrated process design for single-cell analytical technologies. AIChE J. 56, 2496-2502 (2010).

Gong, Y., Ogunniyi, A.O. & Love, J.C. Massively parallel detection of gene expression in single cells using subnanoliter wells. Lab Chip 10, 2334-2337 (2010).

Han, Q., Bradshaw, E.M., Nilsson, B., Hafler, D.A. & Love, J.C. Multidimensional analysis of the frequencies and rates of cytokine secretion from single cells by quantitative microengraving. Lab Chip 10, 1391-1400 (2010). 

Love, K.R., Panagiotou, V., Jiang, B., Stadheim, T.A. & Love, J.C. Integrated single-cell analysis shows Pichia pastoris secretes protein stochastically. Biotechnol. Bioeng. 106, 319-325 (2010).

Choi, J.H., Ogunniyi, A.O., Du, M., Du, M., Kretschmann, M., Eberhardt, J. & Love, J.C. Development and optimization of a process for automated recovery of single cells identified by microengraving. Biotechnol. Prog. 26, 888-895 (2010).

Schmidt, D.J., Pridgen, E.M., Hammond, P.T. & Love, J.C. Layer-by-layer assembly of a pH-sensitive and electrochromic thin film. J. Chem. Educ. 87, 208-211 (2010).

Song, Q., Han, Q., Bradshaw, E.M., Kent, S.C., Raddassi, K., Nilsson, B., Nepom, G.T., Hafler, D.A. & Love, J.C. On-chip activation and subsequent detection of individual antigen-specific T cells. Anal. Chem. 82, 473-477 (2010).

Ogunniyi, A.O., Story, C.M., Papa, E., Guillen, E. & Love, J.C. Screening individual hybridomas by microengraving to discover monoclonal antibodies. Nature Protocols 4, 767-782 (2009).

Hu, C.-C.A., Dougan, S.K., McGehee, A.M., Love, J.C. & Ploegh, H.L. XBP-1 regulates signal transduction, transcription factors and bone marrow colonization in B cells. EMBO J. 28, 1624-1636 (2009).

Ronan, J.L., Story, C.M., Papa, E. & Love, J.C. Optimization of the surfaces used to capture antibodies from single hybridomas reduces the time required for microengraving. J. Immunol. Methods 340, 164-169 (2009).

Story, C.M., Papa, E., Hu, C.-C.A., Ronan, J.L., Herlihy, K., Ploegh, H.L. & Love, J.C. Profiling antibody responses by multiparametric analysis of single B cells. Proc. Natl. Acad. Sci. U. S. A. 105, 17902-17907 (2008).

Bradshaw, E. M., Kent, S. C., Tripuraneni, V., Orban, T., Ploegh, H. L., Hafler, D. A. & Love, J. C. Concurrent detection of secreted products from human lymphocytes by microengraving: cytokines and antigen-reactive antibodies. Clin Immunol 129, 10-18, doi:10.1016/j.clim.2008.06.009 (2008).

Wong, A. P., Castillejos, R. P., Love, J. C. & Whitesides, G. M. Partitioning Microfluidic Channels with Hydrogel to Construct Tunable 3-D Cellular Microenvironments. Biomaterials 29, 1853-1861 (2008).

Whitesides, G. M. & Love, J. C. The Art of Building Small. Scientific American Reports (2007). Leduc, P. R., Wong, M. S., Ferreira, P. M., Groff, R. E., Haslinger, K., Koonce, M. P., Lee, W. Y., Love, J. C., McCammon, J. A., Monteiro-Riviere, N. A., Rotello, V. M., Rubloff, G. W., Westervelt, R. & Yoda, M. Towards an in vivo biologically inspired nanofactory. Nature Nanotechnology 2, 3-7 (2007).

Vyas, J. M., Kim, Y.-M., Artavanis-Tsakonas, K., Love, J. C., van der Veen, A. G. & Ploegh, H. L. Tubulation of Class II MHC compartments is microtubule-dependent and involves multiple endolysosomal membrane proteins in primary dendritic cells. J. Immunol. 178, 7199-7210 (2007).

Leduc, P. R., Wong, M. S., Ferreira, P. M., Groff, R. E., Haslinger, K., Koonce, M. P., Lee, W. Y., Love, J. C., McCammon, J. A., Monteiro-Riviere, N. A., Rotello, V. M., Rubloff, G. W., Westervelt, R. & Yoda, M. Towards an in vivo biologically inspired nanofactory. Nature Nanotechnology 2, 3-7 (2007).

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The Love Lab, 77 Massachusetts Ave, Rm 76-253, Cambridge, MA 02139 | Phone: 617.324.2300 | Updated: August 22, 2013