SPIKE ACQUISITION AT ULTRA-LOW SAMPLING RATES FOR NEUROPROSTHETIC DEVICES L. Srinivasan1*; L. Varshney2; J. Kusuma3 1. San Diego, CA 2. Cambridge, MA 3. Somerville, MA For upper-extremity and other neuroprosthetic devices that rely on action potentials, power consumption, bandwidth, and hardware complexity represent fundamental operating constraints. Here, we present the initial development of a spike acquisition technology to achieve these three demands. Drawing on finite rate of innovation signal theory, our process aims to ultimately acquire the precise shape and timing of spikes from electrodes using sampling rates of 1000 Hz or less. The key insight is that action potentials are essentially stereotyped pulses that are generated by neurons at a rate limited by an absolute refractory period. We use this insight to push sampling below the Nyquist rate. Our approach is parametric and distinct from compressed sensing. The preliminary concept is illustrated with a simulated example from the control of upper-extremity neuroprosthetic devices. Citation:L. Srinivasan, L. R. Varshney, J. Kusuma. SPIKE ACQUISITION AT ULTRA-LOW SAMPLING RATES FOR NEUROPROSTHETIC DEVICES Program No. 20.13 . 2010 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2010. Online. 2010 Copyright by the Society for Neuroscience all rights reserved. Permission to republish any abstract or part of any abstract in any form must be obtained in writing by SfN office prior to publication.