The Lab of Morphogenesis

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Actin network dynamics

In our 2013 Nature Cell Biology paper, Mason et al. show that radial cell polarity of Rho Kinase organizes myosin, actin, and adherens junctions in constricting cells. Video / Frank Mason

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Vasquez C.G., Tworoger, M., A.C. Martin. Dynamic myosin phosphorylation regulates contractile pulses and tissue integrity during epithelial morphogenesis. J. Cell Biol. 2014. Aug 4;206(3):435-50.

Martin A.C., Goldstein B. Apical constriction: themes and variations on a cellular mechanism driving morphogenesis. Development, 2014. 141(10):1987-98.

Chanet S., Martin A.C. Mechanical force sensing in tissues. Prog. Mol. Biol. Transl. Sci. 2014;126:317-52.

Mason F.M., Tworoger M., Martin A.C., Apical domain polarization promotes actin-myosin assembly to drive ratchet-like apical constriction. Nat. Cell Biol. 2013. 15(8):926-36. DOI: 10.1038/ncb2796.

Gelbart M.A., He B., Martin A.C., Thiberge S., Wieschaus E.F., Kaschube M. Volume conservation principle involved in cell lengthening and nucleus movement during tissue morphogenesis. PNAS, 2012, 188(5):735-749.

Mason F.M., Martin A.C.. Tuning cell shape change with contractile ratchets, Curr Opin Genet Dev. 2011. 21(5):671-679. DOI:10.1016/j.gde.2011.08.002.

Martin A.C., M. Gelbart, R. Fernandez-Gonzalez, M. Kaschube, E.F. Wieschaus. Integration of contractile forces during tissue invagination. J. Cell Biol. 2010. 188(5):735-49.

Martin A.C., M. Kaschube, E.F. Wieschaus. Pulsed contractions of an actin-myosin network drive apical constriction. Nature. 2009. 457(7228):495-9.

Martin, A.C. Pulsation and stabilization: Contractile forces that underlie morphogenesis. Dev. Biol. 2010. 341(1):114-25.

Martin A.C., E.F. Wieschaus. Tensions divide. Nat. Cell Biol. 2010. 12(1):5-7.

*Sun Y., *A.C. Martin, D.G. Drubin. Endocytic internalization in budding yeast requires coordinated actin nucleation and myosin motor activity. Dev. Cell. 2006. 11(1):33-46.
*These authors contributed equally to this work.

Martin A.C., M.D. Welch, D.G. Drubin. Arp2/3 ATP hydrolysis-catalysed branch dissociation is critical for endocytic force generation. Nat. Cell Biol. 2006. 8(8):826-33.

Martin A.C., X-P. Xu, I. Rouiller, M. Kaksonen, Y. Sun, L. Belmont, N. Volkmann, D. Hanein, M. Welch, and D.G. Drubin. Effects of Arp2 and Arp3 nucleotide-binding pocket mutations on Arp2/3 complex function. J. Cell Biol. 2005. 168: 315-328.