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Featured videos

Video #1: Laser cutting across the ventral furrow

Laser cutting across the ventral furrowLaser incisions result in elastic recoil of the ventral furrow tissue, demonstrating high levels of tension. Video / Soline Chanet

Video #2: Contraction pulses

Contraction pulsesMyosin contraction is not continuous, but occurs as punctuated events called pulses to drive step-wise apical constriction. Video / Adam Martin

Research highlight

Research in Focus

Selected Publications [full list]

Chanet S., Miller C. J., Vaishnav E. D., Ermentrout B., Davidson L. A., Martin A. C., Actomyosin meshwork mechanosensing enables tissue shape to orient cell force. Nat Commun. 2017 May 15;8:15014. doi: 10.1038/ncomms15014

Heer N. C., Miller P. W., Chanet S., Stoop N., Dunkel J., Martin A. C., Actomyosin-based tissue folding requires a multicellular myosin gradient. Development, Published 2017 May 15. doi: 10.1242/dev.146761

Denk-Lobnig M., Martin A. C., Modular regulation of Rho family GTPases in development. Small GTPases, 2017 Mar 17:1-8. doi: 10.1080/21541248.2017.1294234

Vasquez C. G., Heissler S. M., Billington N., Sellers, J. R., Martin A. C., Drosophila non-muscle myosin II motor activity determines the rate of tissue folding. eLife, Published online 2016 Dec 30. doi: 10.7554/eLife.20828

Coravos J. S., Martin A. C., Actomyosin Pulsing in Tissue Integrity Maintenance during Morphogenesis. Trends Cell Biol., Published online 2016 Dec 15. doi: 10.1016/j.tcb.2016.11.008

Coravos J. S., Martin A. C., Apical sarcomere-like actomyosin contracts nonmuscle Drosophila epithelial cells. Dev Cell. 2016 Nov 7;39(3):346-358. doi: 10.1016/j.devcel.2016.09.023

Mason F. M., Xie S., Vasquez C. G., Tworoger M., Martin A. C., RhoA GTPase inhibition organizes contraction during epithelial morphogenesis. J. Cell Biol. 2016 Aug 29;214(5):603-17. doi: 10.1083/jcb.201603077

Xie S., Mason F. M., Martin A. C., Loss of Gα12/13 exacerbates apical area-dependence of actomyosin contractility. Mol Biol Cell. 2016 Nov 7;27(22):3526-3536. doi: 10.1091/mbc.E16-05-0305

Jodoin J. N., Martin A. C., Abl suppresses cell extrusion and intercalation during epithelium folding. Mol Biol Cell. 2016 Sep 15;27(18):2822-32. doi: 10.1091/mbc.E16-05-0336

Vasquez C. G., Martin A. C., Force transmission in epithelial tissues. Dev Dyn. 2016 Jan 12. doi: 10.1002/dvdy.24384

Jodoin J. N., Coravos J. S., Chanet S., Vasquez C. G., Tworoger M., Kingston E. R., Perkins L. A., Perrimon N., Martin A. C., Stable Force Balance between Epithelial Cells Arises from F-Actin Turnover. Dev Cell. 2015 Dec 21;35(6):685-97. doi: 10.1016/j.devcel.2015.11.018

Rodal A. A., Del Signore S. J., Martin A. C., Drosophila comes of age as a model system for understanding the function of cytoskeletal proteins in cells, tissues, and organisms. Cytoskeleton (Hoboken). 2015 Jun 13. doi: 10.1002/cm.21228.

Xie S., Martin A. C., Intracellular signalling and intercellular coupling coordinate heterogeneous contractile eventsto facilitate tissue folding. Nat Commun. 2015 May 26;6:7161. doi: 10.1038/ncomms8161

Mason F. M., Martin A. C., Crumbling under Pressure. Dev Cell, vol. 33, no. 2, pp. 122–124, Apr. 2015.

Vasquez C. G., Martin A. C., Cell biology: Death drags down the neighbourhood.” Nature, vol. 518, no. 7538, pp. 171–173, Feb. 2015.

Vasquez C.G., Tworoger, M., A.C. Martin. Dynamic myosin phosphorylation regulates contractile pulses and tissue integrity during epithelial morphogenesis. J. Cell Biol. 2014. Aug 4;206(3):435-50.

Martin A.C., Goldstein B. Apical constriction: themes and variations on a cellular mechanism driving morphogenesis. Development, 2014. 141(10):1987-98.

Chanet S., Martin A.C. Mechanical force sensing in tissues. Prog. Mol. Biol. Transl. Sci. 2014;126:317-52.

Mason F.M., Tworoger M., Martin A.C., Apical domain polarization promotes actin-myosin assembly to drive ratchet-like apical constriction. Nat. Cell Biol. 2013. 15(8):926-36. doi: 10.1038/ncb2796.

Gelbart M.A., He B., Martin A.C., Thiberge S., Wieschaus E.F., Kaschube M. Volume conservation principle involved in cell lengthening and nucleus movement during tissue morphogenesis. PNAS, 2012, 188(5):735-749.

Mason F.M., Martin A.C.. Tuning cell shape change with contractile ratchets, Curr Opin Genet Dev. 2011. 21(5):671-679. doi:10.1016/j.gde.2011.08.002.

Martin A.C., M. Gelbart, R. Fernandez-Gonzalez, M. Kaschube, E.F. Wieschaus. Integration of contractile forces during tissue invagination. J. Cell Biol. 2010. 188(5):735-49.

Martin A.C., M. Kaschube, E.F. Wieschaus. Pulsed contractions of an actin-myosin network drive apical constriction. Nature. 2009. 457(7228):495-9.

Martin, A.C. Pulsation and stabilization: Contractile forces that underlie morphogenesis. Dev. Biol. 2010. 341(1):114-25.

Martin A.C., E.F. Wieschaus. Tensions divide. Nat. Cell Biol. 2010. 12(1):5-7.

*Sun Y., *A.C. Martin, D.G. Drubin. Endocytic internalization in budding yeast requires coordinated actin nucleation and myosin motor activity. Dev. Cell. 2006. 11(1):33-46.
*These authors contributed equally to this work.

Martin A.C., M.D. Welch, D.G. Drubin. Arp2/3 ATP hydrolysis-catalysed branch dissociation is critical for endocytic force generation. Nat. Cell Biol. 2006. 8(8):826-33.

Martin A.C., X-P. Xu, I. Rouiller, M. Kaksonen, Y. Sun, L. Belmont, N. Volkmann, D. Hanein, M. Welch, and D.G. Drubin. Effects of Arp2 and Arp3 nucleotide-binding pocket mutations on Arp2/3 complex function. J. Cell Biol. 2005. 168: 315-328.