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Laser cutting across the ventral furrowLaser incisions result in elastic recoil of the ventral furrow tissue, demonstrating high levels of tension. Video / Soline Chanet

Contraction pulsesMyosin contraction is not continuous, but occurs as punctuated events called pulses to drive step-wise apical constriction. Video / Adam Martin

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Research in Focus

Selected Publications [full list]

Vasquez CG, Martin AC., Force transmission in epithelial tissues. Dev Dyn, 2016 Jan 12. doi: 10.1002/dvdy.24384

Jodoin JN, Coravos JS, Chanet S, Vasquez CG, Tworoger M, Kingston ER, Perkins LA, Perrimon N, Martin AC., Stable Force Balance between Epithelial Cells Arises from F-Actin Turnover. Dev Cell, vol. 35, no. 6, pp. 685–697, Dec. 2015

Rodal A. A., Del Signore S. J., Martin A. C., Drosophila comes of age as a model system for understanding the function of cytoskeletal proteins in cells, tissues, and organisms. Cytoskeleton (Hoboken). 2015 Jun 13. DOI: 10.1002/cm.21228.

Xie S., Martin A. C., Intracellular signalling and intercellular coupling coordinate heterogeneous contractile eventsto facilitate tissue folding. Nat Commun, 6:7161, May 2015.

Mason F. M., Martin A. C., Crumbling under Pressure. Dev Cell, vol. 33, no. 2, pp. 122–124, Apr. 2015.

Vasquez C. G., Martin A. C., Cell biology: Death drags down the neighbourhood.” Nature, vol. 518, no. 7538, pp. 171–173, Feb. 2015.

Vasquez C.G., Tworoger, M., A.C. Martin. Dynamic myosin phosphorylation regulates contractile pulses and tissue integrity during epithelial morphogenesis. J. Cell Biol. 2014. Aug 4;206(3):435-50.

Martin A.C., Goldstein B. Apical constriction: themes and variations on a cellular mechanism driving morphogenesis. Development, 2014. 141(10):1987-98.

Chanet S., Martin A.C. Mechanical force sensing in tissues. Prog. Mol. Biol. Transl. Sci. 2014;126:317-52.

Mason F.M., Tworoger M., Martin A.C., Apical domain polarization promotes actin-myosin assembly to drive ratchet-like apical constriction. Nat. Cell Biol. 2013. 15(8):926-36. DOI: 10.1038/ncb2796.

Gelbart M.A., He B., Martin A.C., Thiberge S., Wieschaus E.F., Kaschube M. Volume conservation principle involved in cell lengthening and nucleus movement during tissue morphogenesis. PNAS, 2012, 188(5):735-749.

Mason F.M., Martin A.C.. Tuning cell shape change with contractile ratchets, Curr Opin Genet Dev. 2011. 21(5):671-679. DOI:10.1016/j.gde.2011.08.002.

Martin A.C., M. Gelbart, R. Fernandez-Gonzalez, M. Kaschube, E.F. Wieschaus. Integration of contractile forces during tissue invagination. J. Cell Biol. 2010. 188(5):735-49.

Martin A.C., M. Kaschube, E.F. Wieschaus. Pulsed contractions of an actin-myosin network drive apical constriction. Nature. 2009. 457(7228):495-9.

Martin, A.C. Pulsation and stabilization: Contractile forces that underlie morphogenesis. Dev. Biol. 2010. 341(1):114-25.

Martin A.C., E.F. Wieschaus. Tensions divide. Nat. Cell Biol. 2010. 12(1):5-7.

*Sun Y., *A.C. Martin, D.G. Drubin. Endocytic internalization in budding yeast requires coordinated actin nucleation and myosin motor activity. Dev. Cell. 2006. 11(1):33-46.
*These authors contributed equally to this work.

Martin A.C., M.D. Welch, D.G. Drubin. Arp2/3 ATP hydrolysis-catalysed branch dissociation is critical for endocytic force generation. Nat. Cell Biol. 2006. 8(8):826-33.

Martin A.C., X-P. Xu, I. Rouiller, M. Kaksonen, Y. Sun, L. Belmont, N. Volkmann, D. Hanein, M. Welch, and D.G. Drubin. Effects of Arp2 and Arp3 nucleotide-binding pocket mutations on Arp2/3 complex function. J. Cell Biol. 2005. 168: 315-328.