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Research summary:
I am primarily interested in using single molecule techniques to probe structural biology. With the use of optical tweezers (in collaboration with
Matt Lang, Vanderbilt), I am investigating the force generation mechanism of kinesin. This project also includes comparing our experimental findings
with molecular dynamics simulations (in collaboration with Wonmuk Hwang, Texas A&M). My primary project for my doctoral work will be
to use optical tweezers and potentially other biophysical techniques to study the mechanical properties of amyloid fibers (in collaboration with
Susan Lindquist). We hope that these studies will provide insight into the organization of the monomeric subunits within the amyloid fibril.
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Sup35 NM amyloid fibers labeled with two colors to visualize polymerization.
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