Cortical Development, Plasticity, and Dynamics
Plasticity, or the adaptive response of the brain to changes in inputs, is essential to brain
development and function. The developing brain requires a genetic blueprint but is also acutely
sensitive to the environment. The adult brain constantly adapts to changes in stimuli, and this
plasticity is manifest not only as learning and memory but also as dynamic changes in information
transmission and processing. The goal of the Sur laboratory is to understand long-term plasticity
and short-term dynamics in networks of the developing and adult cortex. In addition, we aim to use
insights from brain development to understand mechanisms of developmental brain disorders.
Perea G, Yang A, Boyden E. and Sur M.
Optogenetic astrocyte activation modulates response selectivity of visual cortex neurons in vivo.
Nature Communications 5: 3262, doi: 10.1038/
Sur M., I. Nagakura, N. Chen and H. Sugihara.
Mechanisms of plasticity in the developing and adult visual cortex.
Progress in Brain Research 207: 243-254, 2013.
Li Y, Wang H, Muffat J, Cheng AW, Orlando DA, Lovén J, Kwok S, Feldman DA, Bateup HS, Gao Q, Hockemeyer D, Mitalipova M, Lewis CA, Vander Heiden MG, Sur M, Young RA, Jaenisch R.
Global Transcriptional and Translational Repression in Human-Embryonic-Stem-Cell-Derived Rett Syndrome Neurons.
Cell Stem Cell 13, 446–458, October 3, 2013. http://dx.doi.org/10.1016/j.stem.2013.09.001.
Response Selectivity Is Correlated to Dendritic Structure in Parvalbumin-Expressing Inhibitory Neurons in Visual Cortex
J Neurosci 33(28): 11724–11733 (2013).
Two-way communication with neural networks in vivo using directed light.
Nature Protocols 8: 1184–1203 (2013).
Mechanisms and therapeutic challenges in autism spectrum disorders: insights from Rett syndrome.
Curr Opin Neurol. 2013 Apr;26(2):154-9. doi: 10.1097/WCO.0b013e32835f19a7.
Nucleus basalis enabled stimulus specific plasticity in the visual cortex is mediated by astrocytes.
Proceedings of the National Academy of Sciences (doi: 10.1073/pnas.1206557109), 2012. [PDF]
Division and subtraction by distinct cortical inhibitory networks in vivo.
Nature 488: 343-348, 2012; doi:10.1038/nature11347. [PDF]