MIT
News "Editors' Choice: Combined Treatment for Rett Syndrome"
Science Signaling, July 15, 2014.

"No longer junk: Role of long noncoding RNAs in autism risk"
SFARI News, March 4, 2014.

"Simple mathematical computations underlie brain circuits: Discovery of how some neurons inhibit others could shed light on autism, other neurological disorders."
MITnews, August 9, 2012.

"The Inner Workings Of Autism,"
Chemical & Engineering News, March 5, 2012.



Changes in brain structure in MeCP2 mutant mice and the effects of IGF-1 treatment

Cortical Development, Plasticity, and Dynamics
Plasticity, or the adaptive response of the brain to changes in inputs, is essential to brain development and function. The developing brain requires a genetic blueprint but is also acutely sensitive to the environment. The adult brain constantly adapts to changes in stimuli, and this plasticity is manifest not only as learning and memory but also as dynamic changes in information transmission and processing. The goal of the Sur laboratory is to understand long-term plasticity and short-term dynamics in networks of the developing and adult cortex. In addition, we aim to use insights from brain development to understand mechanisms of developmental brain disorders.

Latest Publications
Caggiano V, Sur M, Bizzi E.
Rostro-caudal inhibition of hindlimb movements in the spinal cord of mice.
PLoS One. 2014 Jun 25;9(6):e100865. doi: 10.1371/journal.pone.0100865. eCollection 2014. PMID: 24963653


Castro J, Garcia RI, Kwok S, Banerjee A, Petravicz J, Woodson J, Mellios N, Tropea D, and Sur M.
Functional recovery with recombinant human IGF1 treatment in a mouse model of Rett Syndrome.
PNAS Published online before print June 23, 2014, doi: 10.1073/pnas.1311685111.


Mellios N, Woodson J, Garcia RI, Crawford B, Sharma J, Sheridan SD, Haggarty SJ, and Sur M.
2-Adrenergic receptor agonist ameliorates phenotypes and corrects microRNA-mediated IGF1 deficits in a mouse model of Rett syndrome.
PNAS Published online before print June 23, 2014, doi: 10.1073/pnas.1309426111.


Sharma J, Sugihara H, Katz Y, Schummers J, Tenenbaum J, Sur M.
Spatial Attention and Temporal Expectation Under Timed Uncertainty Predictably Modulate Neuronal Responses in Monkey V1.
Cereb Cortex. 2014 May 16. pii: bhu086. [Epub ahead of print] PMID: 24836689


Bosch M, Castro J, Saneyoshi T, Matsuno H, Sur M, Hayashi Y.
Structural and molecular remodeling of dendritic spine substructures during long-term potentiation.
2014 Apr 16;82(2):444-59. doi: 10.1016/j.neuron.2014.03.021. PMID: 24742465


El-Boustani S, Wilson NR, Runyan CA, Sur M.
El-Boustani et al. reply.
Nature. 2014 Apr 3;508(7494):E3-4. doi: 10.1038/nature13130. PMID: 24695315


Khwaja OS, Ho E, Barnes KV, O'Leary HM, Pereira LM, Finkelstein Y, Nelson CA 3rd, Vogel-Farley V, DeGregorio G, Holm IA, Khatwa U, Kapur K, Alexander ME, Finnegan DM, Cantwell NG, Walco AC, Rappaport L, Gregas M, Fichorova RN, Shannon MW, Sur M, Kaufmann WE.
Safety, pharmacokinetics, and preliminary assessment of efficacy of mecasermin (recombinant human IGF-1) for the treatment of Rett syndrome.
Proc Natl Acad Sci U S A. 2014 Mar 25;111(12):4596-601. doi: 10.1073/pnas.1311141111. Epub 2014 Mar 12. PMID: 24623853


Perea G, Yang A, Boyden E. and Sur M.
Optogenetic astrocyte activation modulates response selectivity of visual cortex neurons in vivo.
Nature Communications 5: 3262, doi: 10.1038/ ncomms4262, 2014.


Wilson NR, Schummers J, Runyan CA, Yan SX, Chen RE, Deng Y, Sur M.
Two-way communication with neural networks in vivo using directed light.
Nature Protocols 8: 11841203 (2013).