News "Picower researchers ID brain mechanisms underlying alertness and attentiveness"
Picower Institute for Learning and Memory, April 27, 2015.

"Brainstormers: Obama’s big research push kicks off with a meeting of the minds"
Washington Post, January 2, 2015.

"Picower neuroscientists reveal fundamental discovery about cortical neurons"
MIT News, December 11, 2014.

"This Week in The Journal: Development/Plasticity/Repair STAT1 Regulates Ocular Dominance Plasticity"
The Journal of Neuroscience, July 30, 2014.

"Editors' Choice: Combined Treatment for Rett Syndrome"
Science Signaling, July 15, 2014.

"No longer junk: Role of long noncoding RNAs in autism risk"
SFARI News, March 4, 2014.

"Simple mathematical computations underlie brain circuits: Discovery of how some neurons inhibit others could shed light on autism, other neurological disorders."
MITnews, August 9, 2012.

"The Inner Workings Of Autism,"
Chemical & Engineering News, March 5, 2012.

Changes in brain structure in MeCP2 mutant mice and the effects of IGF-1 treatment

Cortical Development, Plasticity, and Dynamics
Plasticity, or the adaptive response of the brain to changes in inputs, is essential to brain development and function. The developing brain requires a genetic blueprint but is also acutely sensitive to the environment. The adult brain constantly adapts to changes in stimuli, and this plasticity is manifest not only as learning and memory but also as dynamic changes in information transmission and processing. The goal of the Sur laboratory is to understand long-term plasticity and short-term dynamics in networks of the developing and adult cortex. In addition, we aim to use insights from brain development to understand mechanisms of developmental brain disorders.

Latest Publications
Chen N, Sugihara S, Sur M.
An acetylcholine-activated microcircuit drives temporal dynamics of cortical activity.
Nature Neuroscience adv. online pub. 27 Apr 2015; doi:10.1038/nn.4002.

Sur M.
Cortical Development: Transplantation and Rewiring Studies.
In: James D. Wright (editor-in-chief), International Encyclopedia of the Social & Behavioral Sciences, Second Edition, VOL 5: Oxford: Elsevier. pp. 30–34.

S Bavamanian, N Mellios, J Lalonde, DM Fass, J Wang, SD Sheridan, JM Madison, Fen Zhou, EH Rueckert, D Barker, RH Perlis, M Sur, SJ Haggarty
Dysregulation of miR-34a links neuronal development to genetic risk factors for bipolar disorder.
Molecular Psychiatry adv. online pub., 27 January 2015; doi:10.1038/mp.2014.176.

El-Boustani S, Sur M.
Response-dependent dynamics of cell-specific inhibition in cortical networks in vivo.
Nature Communications 11 December 2014; doi:10.1038/ncomms6689.

Cassady JP, D’Alessio AC, Sarkar S, Dani VS, Zi Peng Fan, Ganz K, Roessler R, Sur M, Young RA, Jaenisch R
Direct Lineage Conversion of Adult Mouse Liver Cells and B Lymphocytes to Neural Stem Cells.
Stem Cell Reports 11 December 2014; Vol. 3:948–956.

Landman R, Sharma J, Sur M, Desimone R.
Effect of distracting faces on visual selective attention in the monkey.
PNAS Early Edition 3 December 2014; doi: 10.1073/pnas.1420167111.

Perea G, Sur M, Araque A
Neuron-glia networks: integral gear of brain function.
Front in Cell Neurosci. 8:378, November 2014.

Swiech L, Heidenreich M, Banerjee A, Habib N, Li Y, Trombetta J, Sur M, Zhang F.
In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9.
Nat Biotech. 19 October 2014, doi:10.1038/nbt.3055.

Nagakura, I., A. Van Wart, J. Petravicz, D. Tropea, M. Sur
STAT1 Regulates the Homeostatic Component of Visual Cortical Plasticity via an AMPA Receptor-Mediated Mechanism
The Journal of Neuroscience, 30 July 2014, 34(31): 10256-10263; doi: 10.1523/JNEUROSCI.0189-14.2014

Caggiano V, Sur M, Bizzi E.
Rostro-caudal inhibition of hindlimb movements in the spinal cord of mice.
PLoS One. 25 June 2014;9(6):e100865. doi: 10.1371/journal.pone.0100865. eCollection 2014. PMID: 24963653

Castro J, Garcia RI, Kwok S, Banerjee A, Petravicz J, Woodson J, Mellios N, Tropea D, and Sur M.
Functional recovery with recombinant human IGF1 treatment in a mouse model of Rett Syndrome.
PNAS Published online before print 23 June 2014, doi: 10.1073/pnas.1311685111.

Mellios N, Woodson J, Garcia RI, Crawford B, Sharma J, Sheridan SD, Haggarty SJ, and Sur M.
ß2-Adrenergic receptor agonist ameliorates phenotypes and corrects microRNA-mediated IGF1 deficits in a mouse model of Rett syndrome.
PNAS Published online before print 23 June 2014, doi: 10.1073/pnas.1309426111.