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Marcus_O'Mahony

Marcus O'Mahony, Ph.D.

Postdoctoral Associate

Dept. Chemical Engineering
Massachusetts Institute of Technology Room: E19-536
77 Massachusetts Avenue
Cambridge, MA 02139

Phone: +1 (617) 324-4525 or
+1 (857) 204-7283


E-mail: omahonym@mit.edu

 

 

Education:

  1. Ph.D. Solid State Pharmaceutical Chemistry – Hodnett/Rasmuson Research group, Solid State Pharmaceutical Cluster (SSPC), University of Limerick, Ireland.
  2. B.Sc. Industrial Biochemistry – University of Limerick, Ireland.

 

Research summary:

My research is focused on the crystallization and solid state properties of pharmaceutical compounds. Polymorphism is of particular interest. Specifically, the work of my Ph.D. focused on understanding the mechanism of the solution-mediated polymorphic transformation for the pharmaceutical compound carbamazepine. This transformation was investigated using a variety of techniques such as in situ infra-red spectroscopy, powder and single crystal X-ray diffraction, scanning electron microscopy and in situ optical microscopy. The findings of the work identified that the surface of the metastable phase was responsible for promoting the nucleation of the stable phase during the transformation and that this event was associated with the dissolution of the metastable phase. In additional work, four principal scenarios were distinguished for solution-mediated transformations based on both solution and solid state monitoring. A novel methodology was also developed for measuring the solubility of a metastable crystal phase that transforms quickly to its stable phase.
As a postdoctoral researcher I am interested in the solubility/bioavailability advantage offered by nanosized pharmaceutical crystals. Current work focuses on nanocrystal production in confined environments such as porous materials.

Keywords

Solubility, nanosized pharmaceuticals, porous materials, polymorphism, nucleation, dissolution, solution-mediated transformations, crystallography, process analytical technology, electron microscopy.




The Myerson Group, 77 Massachusetts Ave, Rm 66-568, Cambridge, MA 02139 | Tel: 617.452.3790 | updated: October 10, 2014