Genome

Cardiac development needs more than protein-coding genesBiologists find that long non-coding RNA molecules are necessary to regulate differentiation of embryonic stem cells into cardiac cells.

Editing the genome with high precisionNew method allows scientists to insert multiple genes in specific locations, delete defective genes.

Evolution: It’s all in how you splice itMIT biologists find that alternative splicing of RNA rewires signaling in different tissues and may often contribute to species differences.

Researchers identify biochemical functions for most of the human genomeNew map provides a reference for interpreting function of disease-associated regions.

Turning on key enzyme blocks tumor formationDrug-like molecule restores normal cell metabolism, preventing cancer cells from growing.

Searching genomic data fasterBiologists’ capacity for generating genomic data is increasing more rapidly than computing power. A new algorithm will help them keep up.

Genetic 911: Cells’ emergency systems revealedStudy examines how cells exploit gene sequences to cope with toxic stress.

Getting to the root of geneticsManolis Kellis uses computational techniques to decipher human disease.

Seeing cancer in three dimensionsScientists find that the 3-D structure of a cancer cell’s chromosomes plays a big role in which genes get deleted or copied.

Materials research in the Information AgeMIT, Lawrence Berkeley launch new tool to calculate properties of new materials

Scientists unveil tools for rewriting the code of lifeNew technology from MIT and Harvard can edit DNA at the genome scale, giving cells novel functions.