People

Suresh Ganesan Postdoctoral Associate, Department of Biological Engineering Email: CV Joined the Lab: May 2011 Education Ph.D. in Microbiology and Immunology, Drexel University College of Medicine, 2011 MS- Veterinary Parasitology, Indian Veterinary Research Institute, 2004 DVM- Madras Veterinary College, 2002

Research Summary

A major hurdle in malaria research is the lack of reliable knockdown systems for studying protein function. Our laboratory has discovered an RNA aptamer that binds to the tetracycline repressor protein (TetR) in an anhydrotetracycline-dependent manner. Our studies indicate that the TetR-aptamer system regulates gene expression during the asexual (blood) stages of the malarial parasite. Important aspects of parasite biology also take place during sexual stage development and so I am interested in extending our system to these developmental stages. Overall, this would enable us to more routinely perform functional genetics studies across the entire life cycle of the parasite.

About Me

I hail from a small village in Tamilnadu, the southernmost state of India. Having been exposed to various cultures, I love to taste foods from other parts of the world. My hobbies include watching movies, following cricket (on TV and Internet), reading magazines and listening to music. After coming to USA, I experimented with cooking and discovered my inherent skill at it. Hence, lately I started cooking during my leisure time.

Publications

Ke H, Morrisey JM, Ganesan SM, Mather MW, Vaidya AB. Mitochondrial RNA polymerase is an essential enzyme in erythrocytic stages of Plasmodium falciparum. Mol Biochem Parasitol; 2012; 185(1):48-51.

Nina PB, Morrisey JM, Ganesan SM, Pershing AM, Ke H, Mather MW, Vaidya AB. ATP synthase complex of Plasmodium falciparum: dimeric assembly in mitochondrial membranes and resistance to genetic disruption. J Biol Chem; 2011; 286(48):41312-22.

Ke H, Morrisey JM, Ganesan SM, Painter HJ, Mather MW, Vaidya AB. Variation among Plasmodium falciparum strains in their reliance on mitochondrial electron transport chain functions. Eukaryot Cell; 2011; 10(8):1053-61.

Ganesan SM, Morrisey JM, Mather MW, Vaidya AB. Yeast dihydroorotate dehydrogenase as a new selectable marker for Plasmodium falciparum transfection. Mol Biochem Parasitol; 2011; 177(1):29-34.

Yokananth S, Ghosh S, Gupta SC, Suresh MG, Saravanan D. Characterization of specific and cross-reacting antigens of Fasciola gigantica by immunoblotting. Parasitol Res; 2005; 97(1):41-48.