People

Jeffrey C. Wagner Doctoral Student, Department of Biological Engineering Email: Joined the Lab: Fall 2007 Education A.B. in Genetics, Cell and Developmental Biology modified with Engineering Sciences, Dartmouth College, 2006

Research Summary

While malaria is responsible for approximately 1 million deaths per year, most of which are children under the age of 5, there are few molecular tools for the inducible regulation of gene function. This makes the study of essential genes, which may prove to be ideal drug targets, difficult. My research is focused on developing an inducible transcriptional regulatory system for use in Plasmodium falciparum in order to facilitate the study of essential genes in the parasite.

About Me

When not in the lab, I can frequently be found on the volleyball court or hiking in the white mountains of New Hampshire.  My hobbies also include SCUBA diving and travel.

Publications

Monds RD, Newell PD, Wagner JC, Schwartzman JA, Lu W, Rabinowitz JD, O'Toole GA. Di-adenosine tetraphosphate (Ap4A) metabolism impacts biofilm formation by Pseudomonas fluorescens via modulation of c-di-GMP-dependent pathways. J Bacteriol; 2010; 192(12):3011-23.

Zegans ME, Wagner JC, Cady KC, Murphy DM, Hammond JH, O'Toole GA. Interaction between bacteriophage DMS3 and host CRISPR region inhibits group behaviors of Pseudomonas aeruginosa. J Bacteriol; 2009; 191(1):210-9.