Dr. Otto K. Harling has more than forty years of experience in nuclear science and technology. His research activities have ranged from fundamental physics studies such as neutron scattering verification of the Bose-Einstein Condensate to engineering studies of LWR water chemistry designed to decrease radiation exposure to nuclear power plant workers. He has extensive research and management experience in the national laboratory environment and has been a professor at MIT for the last 23 years. When he came to MIT he assumed direction of a new interdepartmental laboratory, the Nuclear Reactor Laboratory (NRL). He retired from the directorship of the NRL after 20 years and is currently concentrating on research with his graduate students and research associates. His current research is focused on the development of neutron capture therapy (NCT) for cancer. This is a promising binary therapy involving a drug with a suitable capture agent such as B-10 and neutron irradiations. Professor Harling is the MIT principal investigator of a major research project in NCT. He leads the research activities at MIT which are closely coordinated with those of collaborating medical researchers from the Harvard Medical School and elsewhere. Selected recent publications are listed below.

Selected Recent Publications

1. "Boron Neutron Capture Therapy," R. Zamenhof, P. Busse, O. Harling, and J. T. Goorley, Chapter 24, The Modern Technology of Radiation Oncology: A Compendium for Medical Physicists and Radiation Oncology, Medical Physics Publishing, Madison, WI, 1999.
2. "Neutronic Design of a Fission Converter-Based Epithermal Neutron Beam for Neutron Capture Therapy," W. S. Kiger III, S. Sakamoto, and O. K. Harling, Nuclear Science and Engineering: 131, 1-22 (1999).
3. "Complete Response of Cutaneous and Intracranial Melanoma to BNCT," P. Busse, I. Kaplan, R. Zamenhof, O. Harling, J. Kaplan, C. Chuang, J. Goorley, W. S. Kiger III, L. Tank, G. Solares, and M. Palmer, Eighth International Symposium on Neutron Capture Therapy, La Jolla, CA, September 1998.
4. "An Improved Prompt Gamma Neutron Activation Analysis Facility Using a Focused Diffracted Neutron Beam," K. Riley and O. Harling, Nuclear Instruments and Methods in Physics Research, 143, 414-421 (1998).
5. "Sensitivity Studies of Beam Directionality, Beam Size, and Neutron Spectrum for a Fission Converter-Based Epithermal Neutron Beam for Boron Neutron Capture Therapy," S. Sakamoto, W. S. Kiger III, and O. K. Harling, Medical Physics, 26 (9), Sept. 1999.