Associate Professor

LEONID MIRNY, Assistant Professor of Health Sciences & Technology and Physics

Name: Leonid Mirny

Title(s): Associate Professor of Health Sciences & Technology and Physics

Email: leonid@mit.edu

Phone: (617) 452-4862

Assistant: Candance Weaver (617) 253-0009


Massachusetts Institute of Technology
77 Massachusetts Avenue, Bldg. E25-526C
Cambridge, MA 02139

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Research Interests

Professor Mirny's research focuses on computational structural and system biology. His multidisciplinary approach combines first-principle physics with the analysis of biological systems such as genes, proteins, and metabolic pathways. His efforts in computational structural biology involve the development of novel computational tools to analyze and predict structures of proteins, their complexes, and protein-DNA interactions. In these studies, Prof. Mirny seeks to identify amino acids that determine specific DNA recognition, to test these predictions in future experiments, and to find methods to engineer proteins with novel biological functions.

Professor Mirny's system biology projects, which involve the design and simulation of genetic and biochemical networks, integrate large-scale analysis of proteomic and genomic data with molecular simulations of proteins. He is interested in developing stochastic computational models of genetic and biochemical networks, cellular regulation, and signal transduction. Professor Mirny's research seeks to extract efficiently biological knowledge from experimental genomic and proteomic data and to develop a fundamental understanding of the molecular mechanisms involved in cellular regulation. This work aims to reconstruct the cell's entire regulatory network-a goal of both genomics and bioinformatics research.

Biographical Sketch

A researcher in biophysics and computational biology, Prof. Leonid Mirny has taught HST.558 (Introduction to Modeling and Simulation), and has served on HST's Ph.D. Admissions Committee. Following his appointment to the MIT faculty in 2001, he taught Statistical Physics in Biology (8.398). A 1998 Harvard University graduate with a Ph.D. in Biophysics, Prof. Mirny was a Junior Fellow at the Harvard Society of Fellows. He attended the Weizmann Institute of Science (Msc'94, Chemistry) and the Moscow Engineering Physics Institute (Dip'92, Physics).

Selected Publications

  • Mirny, L.A. and Gelfand M.S. "Using orthologous and paralogous proteins to identify specificity determining residues." J. Mol. Biol. 231:7-20 (2002).
  • Mirny, L.A. and Gelfand, M.S. "Structural analysis of conserved base pairs in protein-DNA complexes." Nucl. Acids. Res. 30:1704-1711 (2002).
  • Mirny, L.A. and Shakhnovich, E.I. "Protein Folding Theory: From Lattice to All-Atom Models." Ann. Rev. Biophys. Biomol. Struct. 30:361-396 (2001).
  • Mirny, L.A. and Shakhnovich, E.I "Evolutionary conservation of the folding nucleus." J. Mol. Biol. 308:123-129 (2001).
  • Mirny, L.A., Finkelstein, A., and Shakhnovich, E. "Statistical Significance of Protein Structure Prediction by Threading." Proc. Natl. Acad. Sci. August 22, 2000.
  • Li, L., Mirny, L.A. and Shakhnovich, E.I. "Kinetics, thermodynamics and evolution of non-native interactions in protein folding nucleus." Nature Structural Biol. (4):336-42 (2000).

Last updated on July 25, 2013 4:56 PM