Jeff Gore, Pappalardo
Fellow in Physics: 2007-10
Research Interests
Jeff Gore is currently studying the evolution of cooperation in the laboratory of MIT Prof. Alexander van Oudenaarden. The conditions required for the initiation and maintenance of cooperation is a classic problem in evolutionary biology with deep connections to game theory. Any evolutionary stable state between competing strategies must also be a Nash Equilibrium of the corresponding “game.”
As a model system to explore competition and cooperation experimentally, Jeff is studying the metabolism of sucrose by yeast. The first step of the digestion of the disaccharide sucrose involves enzymatic breakdown of the molecule into its two constituent monosaccharides. This reaction is done outside the cell, making it possible for neighboring cells to “cheat” by consuming the monosaccharides created by other cells.
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Biographical Sketch
Jeff finished his undergraduate studies in physics, mathematics, and economics here at MIT in 1999, and has returned to the Institute after obtaining his PhD from the University of California, Berkeley, in 2005. His research in single-molecule biophysics was done in the laboratory of Carlos Bustamante, focusing on the study of twist and torque in single molecules of DNA.
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Selected Publications
DNA overwinds when stretched, Jeff Gore, Zev Bryant, Marcelo Nollmann, Mai U. Le, Nicholas R. Cozzarelli, and Carlos Bustamante, Nature 442, 836 - 839 (2006).
Mechanochemical analysis of DNA gyrase using rotor bead tracking, Jeff Gore, Zev Bryant, Michael D. Stone, Marcelo Nollmann, Nicholas R. Cozzarelli, and Carlos Bustamante, Nature 439, 100 - 104 (2006).
Structural transitions and elasticity from torque measurements on DNA, Zev Bryant, Michael D. Stone, Jeff Gore, Steven B. Smith, Nicholas R. Cozzarelli, Carlos Bustamante, Nature 424, 338 (2003).
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