Contents

1.Introduction

Five Years of Success

The Pharmaceutical Pipeline A Framework for Integrating POPI Research Components

2. New and Ongoing Research

Drug Development and the Changing Face of R&D

• Exploring the Role of Publicly Funded Research in Private-Sector Pharmaceutical Innovation
• Pharmaceutical R&D in the New Environment
• The Role of Combinatorial Chemistry in Drug Discovery
• The Changing Dynamics of Industry Competition
• Technology Transfer Between Universities and Large Pharmaceutical Firms
• Investment in R&D in the Pharmaceutical and Biotechnology Industries
• Improving the Effectiveness of Pharmaceutical R&D Project Management
• The Determinants of Research Productivity in the Pharmaceutical Industry

The State of Manufacturing in the Pharmaceutical Industry

• Pharmaceutical Manufacturing: What is Its Role?
• Benchmarking the Manufacture of Pharmaceuticals

Linking Business Strategy to the Changing Pharmaceutical Marketplace

• Evaluating Welfare Gains from Pharmaceutical Innovation
• Price Indexes for Anti-Depressant, Anti-Ulcer, and Anti-Hypertensive Drugs: Generics, New Products, and Quality Change
• The Economics of the Anti-Ulcer Drug Market
• Workplace Performance as a Health Outcome Measure

3. Courses, Seminars, and Meetings

Introduction

Courses and Seminars at MIT

Symposia

Invited Seminars

4. POPI Publications

Introduction

Book Summary

Summaries of Selected Recent Working Papers

• Drug Development
• Manufacturing
• The Marketplace

5.Leadership Structure, Participation, and Collaborative Activities

Introduction

Leadership Structure

• Co-Directors
• Advisory Committee

Participation

• Attracting High-Quality Faculty and Students
• Financial Support

Collaborative Activities

• Consortium for the Advancement of Manufacturing in Pharmaceuticals (CAMP)
• Harvard-MIT Center for Experimental Pharmacology and Therapeutics
• Research Program on Pharmaceuticals in the Workplace

Appendix A. POPI Faculty

POPI Co-Directors

MIT Faculty on the POPI Advisory Board

MIT Faculty

Other Faculty

Other Research Collaborators

Appendix B. POPI Students

Appendix C. Articles, Working Papers, and Videos

Appendix D. "Fact-Finding" Visits

Appendix E.Recent Symposium

The Program

Organizations Represented at the Symposium

Appendix F. POPI Advisory Committee

Figures

• Figure 1. Pipeline
• Figure 2. The risk-return "staircase" for pharmaceutical products
• Figure 3. Path analysis of the principal influences on project performance

Please send comments and suggestions to popi-www@mit.edu