Professor of biological engineering and computer science
areas of expertise: molecular modeling of proteins and nucleic acids, protein structure-function relationships, electrostatic determinants of protein binding affinity and specificity, molecular recognition, protein folding, binding and catalysis, rational molecular design, conformational search, physical chemistry, biological chemistry, biomolecular engineering, computational biology, molecular pharmacology, high-throughput data analysis, systems biology, network modeling and design
Bruce Tidor is professor of biological engineering and computer science at MIT. He graduated summa cum laude with an AB in chemistry and physics from Harvard College in 1983, and then received a Marshall Scholar Award to study at Oxford University's Wolfson College, where he earned an MSc in biochemistry. He received his PhD in biophysics from Harvard in 1990 and moved to the Whitehead Institute for Biomedical Research, where he started his independent research as a Whitehead Fellow.
In 1994, he was appointed to the faculty at MIT. He serves as founding co-director of MIT’s Computational and Systems Biology Initiative and also founded the associated PhD program.
Dr. Tidor's research focuses on the analysis of complex biological systems at the molecular and cellular level. Using molecular modeling, theory, and computation, he explores the structure, function, and interactions of proteins and nucleic acids and the roles played by specific chemical groups in defining the stability and specificity of molecular interactions. Using cell-level models, his group is exploring the relationship between network structure and biological function. He is actively involved in applying knowledge from modeling studies to rational design.
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