Daniel K. Ludwig Professor for Cancer Research; Howard Hughes Medical Institute Investigator
areas of expertise: cell adhesion and migration, metastasis and cancer progression (not clinical), tumor microenvironment, angiogenesis and vascular development, stem cells (particularly public policy issues)
Richard Hynes is the Daniel K. Ludwig Professor for Cancer Research at MIT, a Howard Hughes Medical Institute Investigator and a senior associate member of the Broad Institute.
He is a governor of the Wellcome Trust, a major biomedical research charity that funds scientific research and training in the U.K. and in the developing world, including support for the control of new and established infectious diseases. He co-chaired the National Academy Committees that established and implemented guidelines for the conduct of human embryonic stem cell research.
The Hynes laboratory studies the molecular and cellular basis of cell adhesion and its involvement in development, physiology and pathology (inflammation, thrombosis and cancer). Its particular interests focus on cell-matrix adhesion and on adhesion of cells in the vasculature. Both of these involve integrin adhesion receptors and their ligands. The current emphasis of the laboratory is on mechanisms involved in vascular development (cardiogenesis, vasculogenesis, angiogenesis), metastasis and the role of the tumor microenvironment in cancer progression.
The laboratory makes extensive use of mouse models of human diseases and applies cellular and molecular approaches to deciphering the mechanisms underlying the in vivo phenomena revealed in those mouse models.
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