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James Sherley

Assistant Professor
Bioengineering & Environmental Health
Massachusetts Institute of Technology
Building 16, Room 755
77 Massachusetts Avenue
Cambridge, MA 02139

Phone: 617-258-8853
FAX: 617-258-8648
Email: jsherley@mit.edu



B.S. Harvard College 1980
Ph.D., M.D. Johns Hopkins Univ. School of Medicine 1988


Description of Research
Asymmetric cell kinetics and cancer

The main goals of my research program are 1) to elucidate molecular and biochemical mechanisms that govern mammalian cell kinetics; and 2) to apply know ledge of such mechanisms to the detection and treatment of human cancers. We have engineered cell lines to express physiologic levels of the wild-type p53 tumor suppressor protein conditionally. Upon p53 expression, the cells switch from exponential division kinetics to asymmetric division kinetics, producing one dividing cell and one non-dividing quiescent cell at each division. These specialized cells are a model system for investigations of mechanisms that control asymmetric division by somatic stem cells in vivo. Their unique properties are the focus of laboratory and clinical investigations of critical relationships between asymmetric cell kinetics, p53, and cancer.

Recent Papers or Publications
Sherley, J. L., Stadler, P. B., and Johnson, D. R. (1995) "The p53 AntioncogeneInduces Guanine Nucleotide-Dependent Stem Cell Division Kinetics", Proc. Natl. Acad. Sci. 92, 136-140.

Sherley, J. L., Stadler, P. B., and Stadler, J. S. (1995) "A Quantitative Method for the Analysis of Mammalian Cell Proliferation in Culture in Terms of Dividing and Non-dividing Cells", Cell Proliferation 28, 137-144.

Liu, Y., Bohn, S. A., and Sherley, J. L. (1998) "Inosine-5'-Monophosphate Dehydrogenase is a Rate-Determining Factor for p53-Dependent Growth Regulation," Molecular Biology of the Cell 9,15-28.

Special Honors or Awards
Medical Scientist Training Program Awardee 1980

National Research Service Award Fellow 1988

Pew Scholar Award in Biomedical Sciences 1993

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