The remaining chapters of this dissertation are organized as follows. Chapter 2 discusses the evaluation methodology and outlines the overall framework of the simulation laboratory. Chapter 3 describes a microscopic simulator (MITSIM) designed for modeling traffic operations and system performance in integrated traffic networks. Chapter 4 presents a traffic management simulator (TMS) capable of modeling a wide range of traffic management schemes and generating predictive route guidance. Chapter 5 describes a mesoscopic traffic simulator (MesoTS) used as traffic predictor in TMS. In Chapter 6 the developed simulation methodology is demonstrated: a prototypical predictive route guidance system is evaluated using the Amsterdam A10 beltway. Finally, Chapter 7 concludes this dissertation by highlighting the main contributions and discussing directions for future research.