(left to right) Santiago Lima, Jungsan Sohn and wife, Sarah Barkow and friend, Brent Cezairliyan and Eyal Gur at the Bobstock Dinner Celebration, Le Meridien, Cambridge, MA	SAUER LAB General Information The lab uses biophysical, genetic, structural, and design strategies to study the relationship between the sequence, stability, and three-dimensional structures of proteins. We are also interested in the mechanisms that intracellular proteases use to select the correct targets and how ATP-dependent proteases catalyze protein denaturation. HOME

Select Publications Nager, A.R., Baker, T.A. & Sauer, R.T. (2011) Stepwise unfolding of a β-barrel protein by the AAA+ ClpXP protease. J. Mol. Biol. 413, 4-16. Davis, J.H., Baker, T.A. & Sauer, R.T. (2011) Small-molecule control of protein degradation using split adaptors. ACS Chem. Biol. 6, 1205–1213. Aubin-Tam, M.E., Olivares, A.O., Sauer, R.T., Baker, T.A. & Lang, M.J. (2011) Single-molecule protein unfolding and translocation by an ATP-fueled proteolytic machine. Cell 145, 257-267. Kim, S., Grant, R.A. & Sauer, R.T. (2011) Covalent linkage of distinct substrate degrons controls assembly and disassembly of DegP proteolytic cages. Cell 145, 67-78. Sundar, S., McGinness, K.E., Baker, T.A. & Sauer, R.T. (2010) Multiple sequence signals direct recognition and degradation of protein substrates by the AAA+ protease HslUV. J. Mol. Biol. 403, 420-429. Lee, M.E., Baker, T.A. & Sauer, R.T. (2010) Control of substrate gating and translocation into ClpP by channel residues and ClpX binding. J. Mol. Biol. 399, 707-718. Gur, E. & Sauer, R.T. (2009) Degrons in protein substrates program the speed and operating efficiency of the AAA+ Lon proteolytic machine. Proc. Natl. Acad. Sci. USA 106, 18503-18508. Glynn, S.E., Martin, A., Nager, A.R., Baker, T.A. & Sauer, R.T. (2009) Crystal structures of asymmetric ClpX hexamers reveal nucleotide-dependent motions in a AAA+ protein-unfolding machine. Cell 139, 744-756. Barkow, S.R., Levchenko, I., Baker, T.A. & Sauer, R.T. (2009) Polypeptide translocation by the AAA+ ClpXP protease machine. Chem. Biol. 16, 605-612. Cezairliyan, B.O. & Sauer, R.T. (2009) Control of P. aeruginosa AlgW protease cleavage of MucA by peptide signals and MucB. Mol. Micro. 72, 368–379. Sohn, J. & Sauer, R.T. (2009) OMP peptides modulate the activity of DegS protease by differential binding to active and inactive conformations. Mol. Cell 33, 64-74.

The Links Biology Computational Systems Biology Microbiology OpenWetWare	Sauer Lab, Massachusetts Insitute of Technology 77 Massachusetts Avenue, 68-571 Cambridge, MA 02139 Telephone: 617.253.6077, Fax: 617.258.0673 To locate us, please use the following url: http://whereis.mit.edu/map-jpg Contact: Webmaster as follows: sauer-www [at] mit.edu (Email format [at] = @) Copyright 2006