Bob Sauer's Lab

JIEJIN CHEN

Jiejin Chen
Postdoc Associate (2009-Present)
Email (jiejinc at mit.edu)

ANNA DE REGT

Anna de Regt
Graduate Student (2010-Present)
Email (aderegt at mit.edu)

STEVEN GLYNN

Steven Glynn
Postdoc Associate (2005-Present)
Email (seglynn at mit.edu)

Glynn, S.E., Martin, A., Nager, A.R., Baker, T.A. and Sauer R.T. (2009).
Structures of asymmetric ClpX hexamers reveal nucleotide-dependent motions in a AAA+ protein-unfolding machine. Cell, 139, 744-756.

ROBERT A. GRANT

Robert A.Grant
Research Scientist (2000-Present)
Email (ragrant at mit.edu)

Roman-Hernandez, G., Grant, R.A., Sauer, R.T. & Baker, T.A. (2009) Molecular basis of substrate selection by the N-end rule adaptor protein ClpS. Proc. Natl. Acad. Sci USA 106, 8888-8893.

Wang, K.H., Roman-Hernandez, G., Grant, R.A., Sauer, R.T. & Baker, T.A. (2008) The molecular basis of N-end rule recognition. Mol. Cell 32, 406-14.

Chein, P., Grant, R.A., Sauer, R.T. & Baker, T.A. (2007) Structure and substrate specificity of an SspB ortholog: design implications for AAA+ adaptors. Structure 15, 139-145.

Sohn, J., Grant, R.A. & Sauer, R.T. (2007) Allosteric activation of DegS, a stress sensor PDZ-protease. Cell 131, 572-583.

Bolon, D.N., Grant, R.A., Baker, T.A. & Sauer, R.T. (2005) Specificity versus stability in computational protein design. Proc. Natl. Acad. Sci. USA 102, 12724-12729. pubmed. citation

Levchenko, I. Grant, R.A., Flynn, J.M., Sauer, R.T. & Baker, T.A. (2005) Versatile modes of peptide recognition by the AAA+ adaptor protein SspB. Nat. Struct. & Mol. Biol. 12, 520-525. pubmed. citation

Tabtiang, R.K., Cezairliyan, B.O., Grant, R.A, Cochrane, J.C. & Sauer, R.T. (2005) Consolidating critical binding determinants by non-cyclic rearrangement of protein secondary structure. Proc. Natl. Acad. Sci. USA 102, 2305-2309. pubmed. citation

Sauer, R.T., Bolon, D.N., Burton, B.M., Burton, R.E., Flynn, J.M., Grant, R.A., Hersch, G.L., Joshi, S.A., Kenniston, J.A., Levchenko, I., Neher, S.B., Oakes, E.S.C., Siddiqui, S.M., Wah, D.A. & Baker, T.A. (2004) Sculpting the proteome with AAA+ proteases and disassembly machines. Cell 119, 9-18. pubmed. citation

SEOKHEE KIM

Seokhee Kim
Postdoc Associate (2008-Present )
Email (shkim115 at mit.edu )

SANTIAGO LIMA

Santiago Lima
Postdoc Associate (2008-2010) and National Institute of Health Postdoc Fellow (July 2010-Present)
Email (slima at mit.edu)

RANDALL MAULDIN

Randall Mauldin
Postdoc Associate (2010-Present)
Email (rmauldin at mit.edu)

ANDREW R. "DREW" NAGER

Andrew R. Nager
Graduate Student (2009-Present)
Email (andrewn at mit.edu)

Glynn, S.E., Martin, A., Nager, A.R., Baker, T.A. and Sauer R.T. (2009).
Structures of asymmetric ClpX hexamers reveal nucleotide-dependent motions in a AAA+ protein-unfolding machine. Cell, 139, 744-756.

BRENDA E. PEPE

Brenda E. Pepe
Sauer Lab Administrative Lab Support (August 2003 - Present)
Email (pepebe at mit.edu)

Boston College Alumnus
B.A. Class of 85' and M.Ed. 89'

ROBERT T. SAUER

Bob Sauer
Salvador E. Luria Professor of Biology
Principal Investigator (1978-Present)
Email (bobsauer at mit.edu )

Faculty
Massachusetts Institute of Technology

C.V.

Other Activities

Teaching:
Teaches Graduate Biochemistry (7.51)

Topics in Protein Biochemistry (7.76).

Link for Additional Information please see

Bob Sauer's Department of Biology web page

KARL SCHMITZ

Karl Schmitz
Postdoc Associate (2010-Present)
Email (schmitzk at mit.edu)

JUNGSAN "J" SOHN

Jungsan "J" Sohn
National Institutes of Health Postdoc Fellow (2006-Present)
Email (jsohn at mit.edu)

Sohn, J. & Sauer, R.T. (2009) OMP peptides modulate the activity of DegS protease by differential binding to active and inactive conformations. Mol. Cell 33, 64-74.

Sohn, J., Grant, R.A., Sauer, R.T. (2007) Allosteric activation of DegS, a stress sensor PDZ-protease. Cell. 131 572-583.

BENJAMIN STINSON

Ben Stinson
Graduate Student (2010-Present )
Email (bstinson at mit.edu )

SHANKAR SUNDAR

Shankar Sundar
Graduate Student (2007-Present)
Email (ss2 at mit.edu )

Sundar, S., McGinness, K.E., Baker, T.A. & Sauer, R.T. (2010) Multiple sequence signals direct recognition and degradation of protein substrates by the AAA+ protease Hs1UV. J. Mol. Biol. (in press).

MATT WOHLEVER

Matt Wohlever
National Science Foundation
Graduate Research Fellow(2009-Present)
Email (wohlever at mit.edu )