Bob Sauer's Lab

ROBERT T. SAUER

Robert T. Sauer
Salvador E. Luria Professor of Biology
Principal Investigator (1978-Present )
Email (bobsauer at mit.edu )

Faculty
Massachusetts Institute of Technology

(cv download)

Other Activities

Teaching:
Teaches Graduate Biochemistry (7.51)

Topics in Protein Biochemistry (7.76).

Link for Additional Information

Dr. Robert Sauer's Department of Biology page

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BRENDA E. PEPE

Brenda E. Pepe
Administrative Assistant
Robert T. Sauer's Lab - Biology 2003 - Present
Email (pepebe at mit.edu)

Staff
Massachusetts Institute of Technology

ROBERT GRANT

Robert Grant
Research Scientist, Sauer, Baker and Yaffe Labs, (2000-Present)
Email (ragrant at mit.edu)

Chein, P., Grant, R.A., Sauer, R.T. & Baker, T.A. (2007) Structure and substrate specificity of an SspB ortholog: design implications for AAA+ adaptors. Structure (in press).

Sohn, J., Grant, R.A. & Sauer, R.T. (2007) Allosteric activation of DegS, a stress sensor PDZ-protease. Cell (in press).

Bolon, D.N., Grant, R.A., Baker, T.A. & Sauer, R.T. (2005) Specificity versus stability in computational protein design. Proc. Natl. Acad. Sci. USA 102, 12724-12729. pubmed. citation

Levchenko, I. Grant, R.A., Flynn, J.M., Sauer, R.T. & Baker, T.A. (2005) Versatile modes of peptide recognition by the AAA+ adaptor protein SspB. Nat. Struct. & Mol. Biol. 12, 520-525. pubmed. citation

Tabtiang, R.K., Cezairliyan, B.O., Grant, R.A, Cochrane, J.C. & Sauer, R.T. (2005) Consolidating critical binding determinants by non-cyclic rearrangement of protein secondary structure. Proc. Natl. Acad. Sci. USA 102, 2305-2309. pubmed. citation

Sauer, R.T., Bolon, D.N., Burton, B.M., Burton, R.E., Flynn, J.M., Grant, R.A., Hersch, G.L., Joshi, S.A., Kenniston, J.A., Levchenko, I., Neher, S.B., Oakes, E.S.C., Siddiqui, S.M., Wah, D.A. & Baker, T.A. (2004) Sculpting the proteome with AAA+ proteases and disassembly machines. Cell 119, 9-18. pubmed. citation

SEAN MOORE

Sean Moore
Postdoc (2001-Present )
Email (smoore at mit.edu )

Moore, S.E. & Sauer, R.T. (2007) The tmRNA system for translational surveillance and ribosome rescue. Annu. Rev. Biochem. 76.101-124.

Moore, S.D., & Sauer, R.T. (2005) Ribosome rescue: tmRNA tagging activity and capacity in Escherichia coli. Molecular Microbiology 58, 456-66. pubmed citation

Moore, S.D., McGinness, K.E. & Sauer, R.T. (2003) A glimpse into tmRNA-mediated ribosome rescue. Science 300, 72-73.

BRENT CEZAIRLIYAN

Brent Cezairliyan
Graduate Student (2003-Present)
Email (bcez at mit.edu)

Cezairliyan, B.O. & Sauer, R.T. (2007) Inhibition of regulated proteolysis by RseB. Proc. Natl. Acad. Sci. USA (in press).

Tabtiang, R.K., Cezairliyan, B.O., Grant, R.A., Cochrane, J.C. & Sauer, R.T. (2005) Consolidating critical binding determinants by non-cyclic rearrangement of protein secondary structure. Proc. Natl. Acad. Sci. USA 102, 2305-2309. pubmed.citation

ANDREAS MARTIN

Andreas Martin
CSBi Postdoc Fellow (2003-Present )
Email (a_martin at mit.edu )

Martin, A., Baker, T.A. & Sauer, R.T. (2007) Protein unfolding by a AAA+ protease: critical dependence on ATP-hydrolysis rates and energy landscapes. (submitted).

Martin, A., Baker, T.A. & Sauer, R.T. (2007) Distinct static and dynamic interactions control ATPase-peptidase communication in a AAA+ protease. Mol. Cell 27, 41-52.

Martin, A., Baker, T.A. & Sauer, R.T. (2005) Rebuilt AAA+ motors reveal operating principles for ATP-fueled machines. Nature 437, 1115-1120. pubmed citation

JOSEPH YAKAMAVICH

Joe Yakamavich
Graduate Student (2003-Present )
Email (jyak at mit.edu )

SARAH BARKOW

Sarah Barkow
Graduate Student (2005-Present)
Email (barkow at mit.edu)

MARY LEE

Mary Lee
Graduate Student (2005-Present)
Email (marylee at mit.edu)

EYAL GUR

Eyal Gur
Postdoc (2005-Present )
Email (eyalg at mit.edu )

STEVEN GLYNN

Steven Glynn
Postdoc (2005-Present)
Email (seglynn at mit.edu)

NATALIA IVANOVA

Natalia Ivanova
Postdoc (2006-Present )
Email (nivanova at mit.edu

JUNGSAN "J" SOHN

Jungsan "J" Sohn
Postdoc (2006-Present )
Email (jsohn at mit.edu )

Sohn, J., Grant, R.A. & Sauer, R.T. (2007) Allosteric activation of DegS, a stress sensor PDZ-protease. Cell (in press).

SHANKAR SUNDAR

Shankar Sundar
Graduate Student (2007-Present)
Email (ss2 at mit.edu )

JOEY DAVIS

Joey Davis
Graduate Student (2006-Present)
Email (jhdavis at mit.edu)

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