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ROBERT T. SAUER


RTSauer

 

Bob Sauer
Salvador E. Luria Professor of Biology
Principal Investigator (1978 - Present)

Email (bobsauer [at] mit.edu
)

Current C.V.

Kresge, N., Simoni, R., and Hill, R. (2009)
A Model for Protein Turnover: the Work of
Robert T. Sauer
J Biol Chem 284(49): e22-e23, PMC2797215.

Bob Sauer's Biology Webpage

Figone

 

Professor Sauer teaches:

Graduate Biochemistry (7.51)

 

ROBERT A. GRANT

 

ROBERTGRANT

 

Robert A.Grant
Research Scientist (2000 - Present)

Email (ragrant [at] mit.edu
)

BGrant

Román-Hernández G, Hou JY, Grant RA, Sauer RT, Baker TA.(2011) The ClpS adaptor mediates staged delivery of N-end rule substrates to the AAA+ ClpAP protease. Mol Cell. Jul 22;43(2):217-28. PubMed PMID: 21777811; PubMed Central PMCID: PMC3168947.

Kim S, Grant RA, Sauer RT. Covalent linkage of distinct substrate degrons controls assembly and disassembly of DegP proteolytic cages. Cell. 2011 Apr 1;145(1):67-78. PubMed PMID: 21458668; PubMed Central PMCID: PMC3075617.

Wang, K.H., Román-Hernández, G, Grant, R.A., Sauer, R.T. & Baker, T.A. (2008) The molecular basis of N-end rule recognition. Mol. Cell 32(3):406-14. PubMed PMID: 18995838; PubMed Central PMCID: PMC3114436 [Indexed for MEDLINE]

Chein, P., Grant, R.A., Sauer, R.T. & Baker, T.A. (2007) Structure and substrate specificity of an SspB ortholog: design implications for AAA+ adaptors. Structure 15, 139-145.

Sohn, J., Grant, R.A. & Sauer, R.T. (2007) Allosteric activation of DegS, a stress sensor PDZ-protease. Cell 131, 572-583.

Bolon, D.N., Grant, R.A., Baker, T.A. & Sauer, R.T. (2005) Specificity versus stability in computational protein design. Proc. Natl. Acad. Sci. USA 102, 12724-12729. pubmed. citation

KARL SCHMITZ

photo

Karl Schmitz
Postdoc Associate (2010 - Present)

Email (schmitzk [at] mit.edu)

research image

Schmitz, K.R. and Sauer, R.T. (2014) Substrate delivery by the AAA+ ClpX and ClpC1 unfoldases activates the mycobacterial ClpP1P2 peptidase. Mol. Micro. Mol. Microbiology June 27.

Carney, D., Schmitz, K.R., Truong, J., Sauer, R.T., and Sello, J.K. (2014) Restriction of the conformational dynamics of the cyclic acyldepsipeptide macrocycle improves antibacterial activity by enhancing both ClpP peptidase binding and activation. J. Amer. Chem. Soc. 136, 1922-1929.

Carney, D.W., Compton, C.L., Schmitz, K.R., Stevens, J.P., Sauer, R.T. & Jason K. Sello (2014) A simple fragment of the acyldepsipeptide antibacterial agents is necessary and sufficient for ClpP activation and antibacterial activity. Chembiochem. (in press).

Stinson, B.M., Nager, A.R., Glynn, S.E., Schmitz, K.R., Baker, T.A. & Sauer, R.T. (2013) Nucleotide Binding and Conformational Switching in the Hexameric Ring of a AAA+ Machine. Cell 153(3): 628-39.

DOMINIK BARTHELME

Barthelme

Dominik Barthelme
German Research Foundation Fellow
(April 2013 - March 2014)
Postdoc Associate (January 2011 - March 2013 and April 2014 - Present)
Email (dobarthe [at] mit.edu)

DBarthelme

 

Barthelme, D., Chen, J.Z., Grabenstatter, J., Baker, T.A., and Sauer, R.T. (2014) Architecture and assembly of the archaeal Cdc48•20S proteasome. Proc. Natl. Acad. Sci. USA 111, E1687-1694.

Barthelme, D. & Sauer, R.T. (2013) Bipartite determinants mediate an evolutionarily conserved interaction between Cdc48 and the 20S peptidase. Proc. Natl. Acad. Sci. USA 110(9): 3327-32.

Barthelme, D. & Sauer, R.T. (2012) Identification of the Cdc48•20S proteasome as an ancient AAA+ proteolytic machine. Science 2012 Aug 17;337(6096):843-6. Epub 2012 July 26. PMID 22837385.

OHAD YOSEFSON

 

OhadYosefson

 

 

Ohad Yosefson
Postdoc Associate (October 2011 - Present)

Email (ohady [at] mit.edu)

ANNA DE REGT

AnnadeRegt

Anna de Regt

Research Scientist (October 1, 2014-Present)
Microbiology Graduate Student
(June 2010 - September 2014)

Email (aderegt [at] mit.edu)

deRegt

 

de Regt, A.K., Yin, Y., Withers, T.R., Wang, X., Baker, T.A., Sauer, R.T., and Yu, H.D. (2014) Overexpression of CupB5 activates alginate overproduction in Pseudomonas aeruginosa by a novel AlgW-dependent mechanism.
Mol. Microbiol. June 10.

 

 

BENJAMIN STINSON

Ben Stinson
Graduate Student (June 2010 - Present)
and Poitras Pre-doctoral Fellow
(September 2013-August 2014)
Email (bstinson [at] mit.edu
)

Cordova, J.C, Olivares, A.O., Shin, Y., Stinson, B.M., Calmat, S., Schmitz, K.R., Aubin-Tam, M-E. Baker, T.A., Lang, M.J., and Sauer R.T. (2014) Stochastic but highly coordinated protein unfolding and translocation by the ClpXP proteolytic machine. Cell (in press).

Stinson, B.M., Nager, A.R., Glynn, S.E., Schmitz, K.R., Baker, T.A. & Sauer, R.T. (2013) Nucleotide Binding and Conformational Switching in the Hexameric Ring of a AAA+ Machine. Cell 153(3): 628-39.

 

VLADIMIR BAYTSHTOK

 

 

Vlad

 

 

Vladimir Baytshtok
Graduate Student (June 2011 - Present)

Email (vbaytsht [at] mit.edu)

JONATHAN D. GRABENSTATTER

JDGrabenstatter

 

Jon Grabenstatter
Graduate Student (August 2012 - Present )

Email (jgraben [at] mit.edu
)

 

 

Barthelme, D., Chen, J.Z., Grabenstatter, J., Baker, T.A., and Sauer, R.T. (2014) Architecture and assembly of the archaeal Cdc48•20S proteasome. Proc. Natl. Acad. Sci. USA 111, E1687-1694.

 

ALVARO "AJ" AMOR

A_Amon

Alvaro "AJ" Amor
Graduate Student (June 2013 - Present)

Email (alamor [at] mit.edu)

SANJAY HARI

Hari
Sanjay Hari
Postdoc Associate (2014 - Present)

Email (sanjayh [at] mit.edu)

BRENDA E. PEPE

Pepe2014

Brenda E. Pepe
Administrative Lab Support (Aug ust 2003 - Present)
Email (pepebe [at] mit.edu)


1989 M.Ed. Boston College, Graduate School of Arts and Science (Educational Technology)

1985 B.A.
Boston College, Woods College of Advancing Studies (Linguistics)

 

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Sauer Lab, Massachusetts Institute of Technology
77 Massachusetts Avenue, 68-571
Cambridge, MA 02139
Telephone: 617.253.6077, Fax: 617.258.0673

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