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ROBERT T. SAUER


RTSauer

 

Bob Sauer
Salvador E. Luria Professor of Biology
Principal Investigator (1978 - Present)

Email (bobsauer [at] mit.edu
)

Current C.V.

Kresge, N., Simoni, R., and Hill, R. (2009)
A Model for Protein Turnover: the Work of
Robert T. Sauer
J Biol Chem 284(49): e22-e23, PMC2797215.

Bob Sauer's Biology Webpage

 

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Professor Sauer teaches:

Graduate Biochemistry (7.51)

 

ROBERT A. GRANT

 

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Robert A.Grant
Research Scientist (2000 - Present)

Email (ragrant [at] mit.edu
)

BGrant

Román-Hernández G, Hou JY, Grant RA, Sauer RT, Baker TA.(2011) The ClpS adaptor mediates staged delivery of N-end rule substrates to the AAA+ ClpAP protease. Mol Cell. Jul 22;43(2):217-28. PubMed PMID: 21777811; PubMed Central PMCID: PMC3168947.

Kim S, Grant RA, Sauer RT. Covalent linkage of distinct substrate degrons controls assembly and disassembly of DegP proteolytic cages. Cell. 2011 Apr 1;145(1):67-78. PubMed PMID: 21458668; PubMed Central PMCID: PMC3075617.

Wang, K.H., Román-Hernández, G, Grant, R.A., Sauer, R.T. & Baker, T.A. (2008) The molecular basis of N-end rule recognition. Mol. Cell 32(3):406-14. PubMed PMID: 18995838; PubMed Central PMCID: PMC3114436 [Indexed for MEDLINE]

Chein, P., Grant, R.A., Sauer, R.T. & Baker, T.A. (2007) Structure and substrate specificity of an SspB ortholog: design implications for AAA+ adaptors. Structure 15, 139-145.

Sohn, J., Grant, R.A. & Sauer, R.T. (2007) Allosteric activation of DegS, a stress sensor PDZ-protease. Cell 131, 572-583.

Bolon, D.N., Grant, R.A., Baker, T.A. & Sauer, R.T. (2005) Specificity versus stability in computational protein design. Proc. Natl. Acad. Sci. USA 102, 12724-12729. pubmed. citation

KARL SCHMITZ

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Karl Schmitz
Postdoc Associate (2010 - Present)

Email (schmitzk [at] mit.edu)

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Schmitz, K.R. and Sauer, R.T. (2014) Substrate delivery by the AAA+ ClpX and ClpC1 unfoldases activates the mycobacterial ClpP1P2 peptidase Mol. Microbiology 93(4):617-28. doi: 10.1111/mmi.12694. Epub 2014 Jul 13.

Carney, D., Schmitz, K.R., Truong, J., Sauer, R.T., and Sello, J.K. (2014) Restriction of the conformational dynamics of the cyclic acyldepsipeptide macrocycle improves antibacterial activity by enhancing both ClpP peptidase binding and activation. J. Amer. Chem. Soc. 136, 1922-1929.

Carney, D.W., Compton, C.L., Schmitz, K.R., Stevens, J.P., Sauer, R.T. & Jason K. Sello (2014) A simple fragment of the acyldepsipeptide antibacterial agents is necessary and sufficient for ClpP activation and antibacterial activity. Chembiochem. 15(15):2216-20. doi: 10.1111/mmi.12694. Epub 2014 Jul 13.

Stinson, B.M., Nager, A.R., Glynn, S.E., Schmitz, K.R., Baker, T.A. & Sauer, R.T. (2013) Nucleotide Binding and Conformational Switching in the Hexameric Ring of a AAA+ Machine. Cell 153(3): 628-39.

 

OHAD YOSEFSON

 

OhadYosefson

 

 

Ohad Yosefson
Postdoc Associate (October 2011 - Present)

Email (ohady [at] mit.edu)

 

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Yosefson, O., Nager, A.R., Baker, T.A. & Sauer, R.T. (2015) Coordinated gripping of substrate by subunits of a AAA+ proteolytic machine Nat. Chem. Biol. 11(3):201-6. doi: 10.1038/nchembio.1732. Epub 2015 Jan 19

Olivares, A.O., Nager, A.R., Yosefson, O., Sauer, R.T. & Baker, T.A. (2014) Mechanochemical basis of protein degradation by a double-ring AAA+ machine Nat. Struct. Mol. Biol. 21, 871-875.

VLADIMIR BAYTSHTOK

Vlad

 

Vladimir Baytshtok
Graduate Student (June 2011 - Present)

Email (vbaytsht [at] mit.edu)

 

Baytshtok, V., Baker, T.A. & Sauer, R.T. (2015) Assaying the kinetics of protein denaturation catalyzed by AAA+ unfolding machines and proteases. Proc. Natl. Acad. Sci. USA 112, 5377-5382. pubmed. citation

 

 

 

 

 

JONATHAN D. GRABENSTATTER

 

JDGrabenstatter

 

 

Jon Grabenstatter
Graduate Student (August 2012 - Present )

Email (jgraben [at] mit.edu
)

 

 

Barthelme, D., Chen, J.Z., Grabenstatter, J., Baker, T.A., and Sauer, R.T. (2014) Architecture and assembly of the archaeal Cdc48•20S proteasome. Proc. Natl. Acad. Sci. USA 111, E1687-1694.

 

ALVARO "AJ" AMOR

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Alvaro "AJ" Amor
Graduate Student (June 2013 - Present)

Email (alamor [at] mit.edu)

SANJAY HARI

 

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Sanjay Hari
Postdoc Associate (2014 - Present)

Email (sanjayh [at] mit.edu)

 

 

 

XUE FEI

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Xue Fei
Postdoc Associate (2015 - Present)

Email (xfei [at] mit.edu)

BRENDA E. PEPE

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Brenda Ellen Pepe
Administrative Lab Support (Aug ust 2003 - Present)
Email (pepebe [at] mit.edu)


1989 M.Ed. Boston College, Graduate School of Arts and Science (Educational Technology)

1985 B.A.
Boston College, Woods College of Advancing Studies (Linguistics)

 

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Sauer Lab, Massachusetts Institute of Technology
77 Massachusetts Avenue, 68-571
Cambridge, MA 02139
Telephone: 617.253.6077, Fax: 617.258.0673

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