Bob Sauer's Lab

SAUER LAB

BIOLOGY DEPARTMENT
Current Members
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ALVARO "AJ" AMOR

Alvaro "AJ" Amor
Graduate Student (June 2013- Present)
Email (alamor [at] mit.edu)

DOMINIK BARTHELME

Dominik Barthelme
German Research Foundation Fellow
(April 2013-Present)
Postdoc Associate (January 2011-March 2013)
Email (dobarthe [at] mit.edu)

Barthelme, D. & Sauer, R.T. (2013) Bipartite determinants mediate an evolutionarily conserved interaction between Cdc48 and the 20S peptidase. Proc. Natl. Acad. Sci. USA 110(9): 3327-32.

Barthelme, D. & Sauer, R.T. (2012) Identification of the Cdc48•20S proteasome as an ancient AAA+ proteolytic machine. Science 2012 Aug 17;337(6096):843-6. Epub 2012 July 26. PMID 22837385.

VLADIMIR BAYTSHTOK

Vladimir Baytshtok
Graduate Student (June 2011-Present)
Email (vbaytsht [at] mit.edu)

ANNA DE REGT

Anna de Regt
Microbiology Graduate Student
(June 2010-Present)
Email (aderegt [at] mit.edu)

JONATHAN D. GRABENSTATTER

Jon Grabenstatter
Graduate Student (August 2012-Present )
Email (jgraben [at] mit.edu )

ROBERT A. GRANT

Robert A.Grant
Research Scientist (2000-Present)
Email (ragrant [at] mit.edu)

Román-Hernández G, Hou JY, Grant RA, Sauer RT, Baker TA.(2011) The ClpS adaptor mediates staged delivery of N-end rule substrates to the AAA+ ClpAP protease. Mol Cell. Jul 22;43(2):217-28. PubMed PMID: 21777811; PubMed Central PMCID: PMC3168947.

Kim S, Grant RA, Sauer RT. Covalent linkage of distinct substrate degrons controls assembly and disassembly of DegP proteolytic cages. Cell. 2011 Apr 1;145(1):67-78. PubMed PMID: 21458668; PubMed Central PMCID: PMC3075617.

Wang, K.H., Román-Hernández, G, Grant, R.A., Sauer, R.T. & Baker, T.A. (2008) The molecular basis of N-end rule recognition. Mol. Cell 32(3):406-14. PubMed PMID: 18995838; PubMed Central PMCID: PMC3114436 [Indexed for MEDLINE]

Chein, P., Grant, R.A., Sauer, R.T. & Baker, T.A. (2007) Structure and substrate specificity of an SspB ortholog: design implications for AAA+ adaptors. Structure 15, 139-145.

Sohn, J., Grant, R.A. & Sauer, R.T. (2007) Allosteric activation of DegS, a stress sensor PDZ-protease. Cell 131, 572-583.

Bolon, D.N., Grant, R.A., Baker, T.A. & Sauer, R.T. (2005) Specificity versus stability in computational protein design. Proc. Natl. Acad. Sci. USA 102, 12724-12729. pubmed. citation

RUBEN JAUREGUI

Ruben Jauregui
Undergraduate Student (January 2012-June 2013)
Email (ruben_91 [at] mit.edu )

SEOKHEE KIM

Seokhee Kim
The Medical Foundation
Postdoctoral Fellow(July 2012-Present)
and Postdoc Associate (2008-June 2012)
Email (shkim115 [at] mit.edu )

Kim, S. & Sauer, R.T. (2012) Cage assembly of DegP protease is not required for substrate-dependent regulation of Proteolytic activity or high-temperature cell survival. Proc. Natl. Acad. Sci. USA 109(19):7263-7268. Epub 2012 April 23. PMID 22529381 [Indexed for MEDLINE] PMCID: PMC3358883.

Kim, S., Grant, R.A. & Sauer, R. T. (2011) Covalent linkage of distinct substrate degrons controls assembly and disassembly of DegP proteolytic cages.Cell. 2011 Apr 1;145(1):67-78. PubMed PMID: 21458668; PubMed Central PMCID: PMC3075617.

BRENDA E. PEPE

Brenda E. Pepe
Administrative Lab Support (Aug ust 2003-Present)
Email (pepebe [at] mit.edu)

I joined the Sauer Lab in August 2003 after working for many rewarding years first as a legal secretary in downtown Boston and than as a support staff member at Boston College. While working full time at B.C., I enrolled in evening courses at the Woods College of Advancing Studies and ultimately received both a B.A. (1985) and M.Ed. (1989).

I grew up on Massachusetts' South Shore and enjoyed competing in local sailing meets for several years. I now make my home in Abington, Massachusetts. I am an avid genealogist; gardener and I try to travel with some frequency.

ROBERT T. SAUER

Bob Sauer
Salvador E. Luria Professor of Biology
Principal Investigator (1978-Present)
Email (bobsauer [at] mit.edu )

C.V.

Bob Sauer's Biology Webpage

Professor Sauer teaches:

Graduate Biochemistry (7.51)
Topics in Protein Biochemistry (7.76)

KARL SCHMITZ

Karl Schmitz
Postdoc Associate (2010-Present)
Email (schmitzk [at] mit.edu)

Stinson, B.M., Nager, A.R., Glynn, S.E., Schmitz, K.R., Baker, T.A. & Sauer, R.T. (2013) Nucleotide Binding and Conformational Switching in the Hexameric Ring of a AAA+ Machine. Cell 153(3): 628-39.

BENJAMIN STINSON

Ben Stinson
Graduate Student (June 2010-Present)
and Poitras Pre-doctoral Fellow
(September 2013-August 2014)
Email (bstinson [at] mit.edu)

Stinson, B.M., Nager, A.R., Glynn, S.E., Schmitz, K.R., Baker, T.A. & Sauer, R.T. (2013) Nucleotide Binding and Conformational Switching in the Hexameric Ring of a AAA+ Machine. Cell 153(3): 628-39.

MATT WOHLEVER

Matt Wohlever
Graduate Student (June 2009-May 2013)
and Visiting Scientist (June-September 2013)

National Science Foundation
Graduate Research Fellow (2009-2012)
Email (wohlever [at] mit.edu )

Vieux, E.F., Wohlever, M.L., Chen, J.Z., Sauer, R.T. & Baker, T.A. (2013) Distinct quaternary structures of the AAA+ Lon protease control substrate degradation. Proc. Natl. Acad. Sci. USA.

Wohlever ML, Nager AR, Baker TA . & Sauer, RT (2013) Engineering fluorescent protein substrates for the AAA+ Lon Protease . Protein Eng Des Sei - Epub 2013. January 28. PMID 23359718.

OHAD YOSEFSON

Ohad Yosefson
Postdoc Associate (October 2011-Present)
Email (ohady [at] mit.edu)