SAUER LAB

BIOLOGY DEPARTMENT
Current Members
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ALVARO "AJ" AMOR

A_Amon

Alvaro "AJ" Amor
Graduate Student (June 2013 - Present)

Email (alamor [at] mit.edu)

DOMINIK BARTHELME

Barthelme

Dominik Barthelme
German Research Foundation Fellow
(April 2013 - Present)
Postdoc Associate (January 2011 - March 2013)
Email (dobarthe [at] mit.edu)

DBarthelme

 

Barthelme D, Chen JZ, Grabenstatter J, Baker TA, Sauer RT. (2014) Architecture and assembly of the archaeal Cdc48*20S proteasome.Proc Natl Acad Sci U S A. 2014 Apr 7. [Epub ahead of print]

Barthelme, D. & Sauer, R.T. (2013) Bipartite determinants mediate an evolutionarily conserved interaction between Cdc48 and the 20S peptidase. Proc. Natl. Acad. Sci. USA 110(9): 3327-32.

Barthelme, D. & Sauer, R.T. (2012) Identification of the Cdc48•20S proteasome as an ancient AAA+ proteolytic machine. Science 2012 Aug 17;337(6096):843-6. Epub 2012 July 26. PMID 22837385.

 

VLADIMIR BAYTSHTOK

 

 

Vlad

 

 

Vladimir Baytshtok
Graduate Student (June 2011 - Present)

Email (vbaytsht [at] mit.edu)

ANNA DE REGT

AnnadeRegt

Anna de Regt
Microbiology Graduate Student
(June 2010 - Present)

Email (aderegt [at] mit.edu)

JONATHAN D. GRABENSTATTER

JDGrabenstatter

 

Jon Grabenstatter
Graduate Student (August 2012 - Present )

Email (jgraben [at] mit.edu
)

 

 

Barthelme D, Chen JZ, Grabenstatter J, Baker TA, Sauer RT. (2014) Architecture and assembly of the archaeal Cdc48*20S proteasome.Proc Natl Acad Sci U S A. 2014 Apr 7. [Epub ahead of print]

ROBERT A. GRANT

 

ROBERTGRANT

 

Robert A.Grant
Research Scientist (2000 - Present)

Email (ragrant [at] mit.edu
)

BGrant

 

Román-Hernández G, Hou JY, Grant RA, Sauer RT, Baker TA.(2011) The ClpS adaptor mediates staged delivery of N-end rule substrates to the AAA+ ClpAP protease. Mol Cell. Jul 22;43(2):217-28. PubMed PMID: 21777811; PubMed Central PMCID: PMC3168947.

Kim S, Grant RA, Sauer RT. Covalent linkage of distinct substrate degrons controls assembly and disassembly of DegP proteolytic cages. Cell. 2011 Apr 1;145(1):67-78. PubMed PMID: 21458668; PubMed Central PMCID: PMC3075617.

Wang, K.H., Román-Hernández, G, Grant, R.A., Sauer, R.T. & Baker, T.A. (2008) The molecular basis of N-end rule recognition. Mol. Cell 32(3):406-14. PubMed PMID: 18995838; PubMed Central PMCID: PMC3114436 [Indexed for MEDLINE]

Chein, P., Grant, R.A., Sauer, R.T. & Baker, T.A. (2007) Structure and substrate specificity of an SspB ortholog: design implications for AAA+ adaptors. Structure 15, 139-145.

Sohn, J., Grant, R.A. & Sauer, R.T. (2007) Allosteric activation of DegS, a stress sensor PDZ-protease. Cell 131, 572-583.

Bolon, D.N., Grant, R.A., Baker, T.A. & Sauer, R.T. (2005) Specificity versus stability in computational protein design. Proc. Natl. Acad. Sci. USA 102, 12724-12729. pubmed. citation

 

RUBEN JAUREGUI

 

Jauregui

 

Ruben Jauregui
Technical Assistant (August 2013 - Present)

Email (ruben_91 [at] mit.edu
)

BRENDA E. PEPE

BPepe

 

Brenda E. Pepe
Administrative Lab Support
(Aug ust 2003 - Present)
Email (pepebe [at] mit.edu)

I joined the Sauer Lab in August 2003 after a rewarding career at Boston College. Additionally, I volunteer my time with the MIT Women's League.


ROBERT T. SAUER


RTSauer

 

Bob Sauer
Salvador E. Luria Professor of Biology
Principal Investigator (1978 - Present)

Email (bobsauer [at] mit.edu
)

Current C.V.

Kresge, N., Simoni, R., and Hill, R. (2009)
A Model for Protein Turnover: the Work of Robert T. Sauer
J Biol Chem 284(49): e22-e23, PMC2797215.

Bob Sauer's Biology Webpage

Figone

 

Professor Sauer teaches:

Graduate Biochemistry (7.51)
Topics in Protein Biochemistry (7.76)

 

 

 

KARL SCHMITZ

Karl Schmitz
Postdoc Associate (2010 - Present)

Email (schmitzk [at] mit.edu)

 

Stinson, B.M., Nager, A.R., Glynn, S.E., Schmitz, K.R., Baker, T.A. & Sauer, R.T. (2013) Nucleotide Binding and Conformational Switching in the Hexameric Ring of a AAA+ Machine. Cell 153(3): 628-39.

 

JASON SELLO

 

JASON SELLO

 

 

 

Jason Sello
Martin Luther King, Jr. Visiting Associate Professor (September 2013 -
Present)
Email (jsello [at] mit.edu)

 

BENJAMIN STINSON

Ben Stinson
Graduate Student (June 2010 - Present)
and Poitras Pre-doctoral Fellow
(September 2013-August 2014)
Email (bstinson [at] mit.edu
)

 

Stinson, B.M., Nager, A.R., Glynn, S.E., Schmitz, K.R., Baker, T.A. & Sauer, R.T. (2013) Nucleotide Binding and Conformational Switching in the Hexameric Ring of a AAA+ Machine. Cell 153(3): 628-39.

 

OHAD YOSEFSON

 

OhadYosefson

 

 

Ohad Yosefson
Postdoc Associate (October 2011 - Present)

Email (ohady [at] mit.edu)

 

 

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Sauer Lab, Massachusetts Institute of Technology
77 Massachusetts Avenue, 68-571
Cambridge, MA 02139
Telephone: 617.253.6077, Fax: 617.258.0673

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