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ROBERT T. SAUER

RTSauer

 

Bob Sauer
Salvador E. Luria Professor of Biology
Principal Investigator (1978 - Present)

Email (bobsauer [at] mit.edu
)

Current C.V.

Kresge, N., Simoni, R., and Hill, R. (2009)
A Model for Protein Turnover: the Work of
Robert T. Sauer
J Biol Chem 284(49): e22-e23, PMC2797215.

Bob Sauer's Biology Webpage

 

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Professor Sauer teaches:

Graduate Biochemistry (7.51)

 

ROBERT A. GRANT

 

ROBERTGRANT

 

Robert A.Grant
Research Scientist (2000 - Present)

Email (ragrant [at] mit.edu
)

BGrant

Román-Hernández G, Hou JY, Grant RA, Sauer RT, Baker TA.(2011) The ClpS adaptor mediates staged delivery of N-end rule substrates to the AAA+ ClpAP protease. Mol Cell. Jul 22;43(2):217-28. PubMed PMID: 21777811; PubMed Central PMCID: PMC3168947.

Kim S, Grant RA, Sauer RT. Covalent linkage of distinct substrate degrons controls assembly and disassembly of DegP proteolytic cages. Cell. 2011 Apr 1;145(1):67-78. PubMed PMID: 21458668; PubMed Central PMCID: PMC3075617.

Wang, K.H., Román-Hernández, G, Grant, R.A., Sauer, R.T. & Baker, T.A. (2008) The molecular basis of N-end rule recognition. Mol. Cell 32(3):406-14. PubMed PMID: 18995838; PubMed Central PMCID: PMC3114436 [Indexed for MEDLINE]

Chein, P., Grant, R.A., Sauer, R.T. & Baker, T.A. (2007) Structure and substrate specificity of an SspB ortholog: design implications for AAA+ adaptors. Structure 15, 139-145.

Sohn, J., Grant, R.A. & Sauer, R.T. (2007) Allosteric activation of DegS, a stress sensor PDZ-protease. Cell 131, 572-583.

Bolon, D.N., Grant, R.A., Baker, T.A. & Sauer, R.T. (2005) Specificity versus stability in computational protein design. Proc. Natl. Acad. Sci. USA 102, 12724-12729. pubmed. citation

KARL SCHMITZ

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Karl Schmitz
Postdoc Associate (201 -June 2015)
and
Postdoc Fellow (July 2015-Present)
The Medical Foundation
Email (schmitzk [at] mit.edu)

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Schmitz, K.R. and Sauer, R.T. (2014) Substrate delivery by the AAA+ ClpX and ClpC1 unfoldases activates the mycobacterial ClpP1P2 peptidase Mol. Microbiology 93(4):617-28. doi: 10.1111/mmi.12694. Epub 2014 Jul 13.

Carney, D., Schmitz, K.R., Truong, J., Sauer, R.T., and Sello, J.K. (2014) Restriction of the conformational dynamics of the cyclic acyldepsipeptide macrocycle improves antibacterial activity by enhancing both ClpP peptidase binding and activation. J. Amer. Chem. Soc. 136, 1922-1929.

Carney, D.W., Compton, C.L., Schmitz, K.R., Stevens, J.P., Sauer, R.T. & Jason K. Sello (2014) A simple fragment of the acyldepsipeptide antibacterial agents is necessary and sufficient for ClpP activation and antibacterial activity. Chembiochem. 15(15):2216-20. doi: 10.1111/mmi.12694. Epub 2014 Jul 13.

Stinson, B.M., Nager, A.R., Glynn, S.E., Schmitz, K.R., Baker, T.A. & Sauer, R.T. (2013) Nucleotide Binding and Conformational Switching in the Hexameric Ring of a AAA+ Machine. Cell 153(3): 628-39.

 

OHAD YOSEFSON

 

OhadYosefson

 

 

Ohad Yosefson
Postdoc Associate (October 2011-Present)

Email (ohady [at] mit.edu)

 

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Yosefson, O., Nager, A.R., Baker, T.A. & Sauer, R.T. (2015) Coordinated gripping of substrate by subunits of a AAA+ proteolytic machine Nat. Chem. Biol. 11(3):201-6. doi: 10.1038/nchembio.1732. Epub 2015 Jan 19

Olivares, A.O., Nager, A.R., Yosefson, O., Sauer, R.T. & Baker, T.A. (2014) Mechanochemical basis of protein degradation by a double-ring AAA+ machine Nat. Struct. Mol. Biol. 21, 871-875.

VLADIMIR BAYTSHTOK

Vlad

 

Vladimir Baytshtok
Graduate Student (June 2011 - Present)

Email (vbaytsht [at] mit.edu)

 

Baytshtok, V., Baker, T.A. & Sauer, R.T. (2015) Assaying the kinetics of protein denaturation catalyzed by AAA+ unfolding machines and proteases. Proc. Natl. Acad. Sci. USA 112, 5377-5382. pubmed. citation

 

 

 

 

 

ALVARO "AJ" AMOR

 

A_Amon

 

Alvaro "AJ" Amor
Graduate Student (June 2013 - Present)

Email (alamor [at] mit.edu)


SANJAY HARI

 

Hari

 

Sanjay Hari
Postdoc Associate (2014-August 2015)
and
NIH Postdoc Fellow (September 2015-Present)
Email (sanjayh [at] mit.edu)

 

XUE FEI

 

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Xue Fei
Postdoc Associate (March 2015-Present)

Email (xfei [at] mit.edu)


REUBEN SAUNDERS

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Reuben Saunders
UROP (2015-Present)
Email (reubens [at] mit.edu)



 

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Sauer Lab, Massachusetts Institute of Technology
77 Massachusetts Avenue, 68-571
Cambridge, MA 02139
Telephone: 617.253.6077, Fax: 617.258.0673

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