Current Members







Bob Sauer

Salvador E. Luria Professor of Biology
Principal Investigator (1978 - Present)

Email (bobsauer [at]

Current C.V.

Kresge, N., Simoni, R., and Hill, R. (2009)
A Model for Protein Turnover: the Work of
Robert T. Sauer
J Biol Chem 284(49): e22-e23, PMC2797215.

Bob Sauer's Biology Webpage






Professor Sauer teaches:

Graduate Biochemistry (7.51)






Robert A.Grant

esearch Scientist (2000 - Present)
Email (ragrant [at]


Stein, B.J., Grant, R.A., Sauer, R.T., & Baker, T.A. (2016) Structural basis of an N-degron adaptor with more stringent specificityStructure 2, 232-242.

Román-Hernández G, Hou JY, Grant RA, Sauer RT, Baker TA.(2011) The ClpS adaptor mediates staged delivery of N-end rule substrates to the AAA+ ClpAP protease. Mol Cell. Jul 22;43(2):217-28. PubMed PMID: 21777811; PubMed Central PMCID: PMC3168947.

Kim S, Grant RA, Sauer RT. Covalent linkage of distinct substrate degrons controls assembly and disassembly of DegP proteolytic cages. Cell. 2011 Apr 1;145(1):67-78. PubMed PMID: 21458668; PubMed Central PMCID: PMC3075617.

Wang, K.H., Román-Hernández, G, Grant, R.A., Sauer, R.T. & Baker, T.A. (2008) The molecular basis of N-end rule recognition. Mol. Cell 32(3):406-14. PubMed PMID: 18995838; PubMed Central PMCID: PMC3114436 [Indexed for MEDLINE]

Chein, P., Grant, R.A., Sauer, R.T. & Baker, T.A. (2007) Structure and substrate specificity of an SspB ortholog: design implications for AAA+ adaptors. Structure 15, 139-145.

Sohn, J., Grant, R.A. & Sauer, R.T. (2007) Allosteric activation of DegS, a stress sensor PDZ-protease. Cell 131, 572-583.

Bolon, D.N., Grant, R.A., Baker, T.A. & Sauer, R.T. (2005) Specificity versus stability in computational protein design. Proc. Natl. Acad. Sci. USA 102, 12724-12729. pubmed. citation





Sanjay Hari

Postdoc Associate (2014-August 2015) and September 2017 - Present
NIH Postdoc Fellow (September 2015-August 2017)
Email (sanjayh [at]


Amberg-Johnson, K., Hari, S.B, Ganesan, S.M, Lorenzi, H.A, Sauer, R.T, Niles, J.C, & Yeh, E. (2017) Small molecule inhibition of apicomplexan FtsH1 disrupts plastid biogenesis in human pathogens. Elife 6.

Hari, S.B., and Sauer, R.T. (2016) The AAA+ FtsH Protease Degrades an ssrA-Tagged Model Protein in the Inner Membrane of Escherichia coli. Biochemistry Sep. 30 2016.



XueFei Image


Xue Fei

Postdoc Associate (February 2015-Present)
Email (xfei [at]





Erin Devine

Postdoc Associate (February 2016 - Present)
Email (edevine [at]





Tristan Bell

Graduate Student (June 2016-Present)
Email (tribell [at]





Juhee Park

Graduate Student (June 2016-Present)
Email (jpark05 [at]





Curran Oi
Graduate Student - Exchange Scholar

(March 2018 - Present)
Email (curranoi [at] and curran.oi [at]




Brenda Ellen Pepe
Administrative Assistant

For Professor Robert T. Sauer and the Sauer Lab
Email (pepebe [at]

Boston College alumnus, class of '85 (WCAS) and '89 (GA&S).