There are two sets of directions below: the basic directions from the front entry of MIT at 77 Massachusetts Ave, and directions from the Council room (6-120) for those folks who have figured out the better parking to be had near there.
Room 4-153 is on a side corridor off the Infinite Corridor, to the right one intersection past Lobby 10, the war memorial lobby.
Enter, and proceed across lobby and into corridor on far side. This is the Infinite Corridor (main MIT landmark). Proceed past one intersection, and on through a smaller lobby (Lobby 10). At the next major instersection, turn right. About three-quarters of the way down on the left is 4-153.
Go back up to the Infinite Corridor, and head down it (you're at the end, there's only one direction to go) to the next intersection. Turn left. About three-quarters of the way down on the left is 4-153.
IF YOU GET LOST ask a native. Room is pronounced "Four, One Fifty Three". Articulated thus, natives will know where that it.