Protein folding is one of the most complicated problems in structural
biology. Although it is not yet possible to reliably predict the native
structure of a protein from its sequence, the understanding of
mechanisms governing protein folding, which also lead to better
structure prediction algorithms, has progressed considerably.
A number of mechanisms, such as “molten globule” model and “Folding Funnels” model, etc, have been proposed to explain how
naturally occurring proteins reach their native structures with a
biologically relevant time scale. However, most of the mechanism
only can qualitatively describe protein folding process. In this project,
by using thermodynamics, kinetics and statistical methods, we will
construct protein folding model which can give the quantitative
information of protein folding.