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Expertise: Synthesis and characterization of novel [60]Fullerene Containing well-defined stimuli responsive amphiphilic block copolymers for biomedical applications
Synthesis and Characterization of Stimuli Responsive [60]Fullerene Containing Amphiphilic Block Copolymers for Targeted Drug Delivery
Project Advisor
Assoc Prof Tam K. C., Michael
Duration :
August 2003 to August 2005

Project Abstract:

This project focuses on developing novel stimuli-sensitive fullerene (C60) containing well-defined polymers for drug and gene delivery applications. Three major stimuli responsive C60 containing polymer systems will be considered; namely polymethacrylic acid/ polyacrylic acid-block-C60 (PMAA-b-C60/PAA-b-C60), poly(2- (diethylaminoethyl methacrylate)/2-(dimethylaminoethyl methacrylate)-block-C60 (PDMA-b-C60/PDEA-b-C60) and betainised poly(2-(diethylaminoethyl methacrylate)-block-C60 (Bet-PDMA-b- C60). The self-assembly of these materials produces a complex hierarchical structure that can be harnessed for potential applications described in this proposal. The atom transfer radical polymerisation (ATRP) will be adopted to synthesize a range of mono-dispersed block copolymers. Other stimuli-sensitive functional groups can be used to impart pH, temperature and electrolyte (salt) sensitivity to the polymers. These polymers exhibit interesting microstructure for potential drug delivery applications.

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