Singapore-MIT Alliance for Research & Technology
One organizing theme of research in the BioSyM program is that mechanical forces and interactions are critical regulators and indicators of molecular, cellular, and tissue functions. It is now widely recognized, for example, that mechanical signaling pathways operate in parallel with biochemical ones in regulating biological function. This mechanical/biochemical coupling in biology offers diverse opportunities to diagnose, intervene, and control biological outcomes from the molecular to tissue levels. The work of BioSyM will have broad impact on many pathophysiological states since there is ample evidence that many mechanical/biochemical coupling mechanisms are ubiquitous in biology. Our major goals are to develop novel imaging, manipulation, measurement and control platforms that are applicable from the molecular to the tissue levels; and to apply these platforms for fundamental studies relevant to tissue degenerative diseases, fibrosis and drug screening targets. The integrated research efforts will bridge key gaps between engineering and molecular/cell biology by bringing together technologists in micro- and nanofabrication; single-molecule and single-cell manipulation; 3D molecular, cell, and tissue imaging; and computational biology with engineers, biologists, and clinicians focused on developing new tissue-based disease models, diagnostics, and treatment modalities.
Our overall goal is to develop fundamental understanding of the interactions between mechanics, biology, and tissue disease at multiple length-scales, from molecules to cells to tissues. This goal will be accomplished through novel, directed experiments that are guided and interpreted by analytical and computational models at each scale. To achieve this goal we carry out projects which are driven by the 4 thrusts.
The four thrusts are
These Thrusts continue to be based on a combination of innovative technologies applied to critical biomedical issues, and are based on platforms or methodologies including Micro / Nanofluidics, Imaging, Computation / Theory and Materials / Mechanics.
Global Enterprise for Micro Mechanics and Molecular Medicine (GEM4): www.gem4.org
Mechanobiology Institute: http://mbi.nus.edu.sg/
Singapore-MIT Alliance for Research and Technology (SMART): http://smart.mit.edu/home.html