Singapore-MIT Alliance for Research & Technology

Biosystems and Micromechanics

#04-13/14 Enterprise Wing and #B-101
Singapore 138602

BioSystems and Micromechanics (BioSyM) - IRG

Thiery, Jean Paul
Principal Investigator and Deputy Director, Institute of Molecular and Cell Biology (IMCB), Singapore
Chief Scientific Officer Experimental Therapeutic Centre
Adjunct Professor of Pathology NUH-NUS


  • 1968 Masters in Physical Chemistry
  • Engineering Diploma in Chemistry (Ecole Nationale Supérieure Chimie Strasbourg), placed first in the year.
  • 1968 Diploma Organic Chemistry of Natural Substances
  • 1974 Doctorat d'Etat Thesis, Institut Jacques Monod, Paris
  • 1968-1974 Research position, CNRS, Strasbourg and Institut Jacques Monod, Paris
  • 1975-1977 Postdoctoral fellow, laboratory of Professor Gerald M. Edelman, The Rockefeller University, New-York
  • 1978-1982 Senior Research Associate CNRS, Institute of Embryology, CNRS and the Collège de France, Nogent sur Marne, France
  • 1982-1987 Director of Research CNRS, Institute of Embryology, Nogent sur Marne
  • 1987-1994 Director of the Laboratory of Physiopathology of Development of the CNRS and Ecole Normale Supérieure, Paris, France
  • 1989 Director of Research CNRS First Class
  • 1995-2003 Director of the laboratory of ‘Subcellular Structure and Cellular Dynamics’ of the CNRS and the Institut Curie, Paris, France
  • 1999 Director of Research CNRS Exceptional Class
  • 2001- Scientific Officer Ministry of Research and Technology
  • 2003- 2006 Director Department of Translational Research – Institut Curie Paris
  • 2006- Principal Investigator (IMCB) A*STAR, Singapore
  • 2008  Associate Principal investigator RCE mechanobiology

Selected Publications: (from over 300 peer reviewed articles)

  • Tabdanov E, Borghi N, Brochard-Wyart, F, Dufour, and Thiery JP (2009). Role of E-cadherin in cellular nanotube extrusion. Biophys.J. 6: 2457-2461.
  • Cuvelier D., Thery M., Chu Y.S., Dufour S., Thiery JP., Bornens M., Nassoy P. and Mahadevan L 2007 The universal dynamics of cell spreading. Curr. Biol 17: 694-699
  • Thiery JP., Sleeman J., (2006) Complex networks orchestrate epithelial-mesenchymal transitions. Nature Rev. Mol. Cell Biol. 7: 131-142
  • Breau M., Eder O., Blanche M., Brakebush C., Fassler R., Thiery J.P. and Dufour S. (2006) Removal of b1 integrin in the enteric neural crest lead to a Hirschprung disease. Development 133 : 1725 – 1734.
  • Chu Y. S., Dufour S., Thiery J. P., Perez E. and Pincet F. (2005) Johnson-Kendall-Roberts theory applied to living cells. Phys. Rev. Lett.94: 028102.
  • Chu Y-S., Thomas W., Eder O., Pincet F., Perez E., Thiery J.P. and Dufour S. (2004) Quantification of separation forces in E-cadherin mediated cell doublets reveals rapid adhesion strengthened by actin cytoskeleton remodeling through Rac and Cdc-42 but not Rho. J. Cell Biol. 167: 1183-1194.

Current Research Support

  • Research Support Intramural A*STAR