Selected Publications
Selected Publications
•Runguphan, W.*, Xudong, Q.*, O’Connor, S. E. Introduction of halogenation to medicinal plant metabolism. submitted.
* denotes equal authorship
•Bernhardt, P., Usera, A.R., O’Connor, S.E. Biocatalytic asymmetric formation of tetrahydro-beta-carbolines. submitted.
•Lee, H.-Y., Yerkes, N., O’Connor, S.E. Aza-tryptamine substrates in natural product biosynthesis. Chem. Biol., in revision.
• Runguphan, W. Maresh, J. J., O’Connor, S. E. (2009) Silencing of tryptamine
biosynthesis for production of unnatural alkaloids in plant culture. Proc. Natl.
Acad. Sci. USA 106, 13673-13678.
• Bernhardt, P.*, Yerkes, N.*, O’Connor, S. E. (2009) Chemo-enzymatic synthesis of
heteroyohimbine alkaloid stereoisomers. Org. Biomol. Chem. 7, 4166-4168.
* denotes equal authorship
• Usera, A.R., O'Connor, S.E. (2009) Mechanistic advances in plant natural product
enzymes. Curr. Opin. Chem. Biol. 13, 485-491.
•O’Connor, S. E. peer reviewed chapter “Alkaloids” for “Comprehensive Natural Products II” accepted.
•Leonard, E., Runguphan, W., O’Connor, S., Prather, K. J. (2009) Opportunities in metabolic engineering to enable scalable alkaloid production. Nat. Chem. Biol. 5, 292-300.
•Bernhardt, P., O’Connor, S. E. (2009) Opportunities for enzyme engineering in natural product biosynthesis. Curr. Opin. Chem. Biol. 13, 35-42.
•Runguphan, W., O’Connor, S. E. (2009) Metabolic reprogramming of periwinkle plant culture. Nat. Chem. Biol. 5, 151-153.
•Friedrich, A., Brase, S., O’Connor, S. E. (2009) Synthesis of 4, 5, 6 and 7 azido tryptamines, Tetrahedron Lett. 50, 75-76.
•O’Connor, S. E. (2008) peer reviewed chapter “Elucidation of Natural Product
Pathways in Plants" for "Plant-derived natural products; Synthesis, function and
application" in press.
• Maresh, J., Giddings, L. A., Friedrich, A., Loris, E. A., Panjikar, S., Stockigt, J.,
Peters, B., O’Connor, S. E. (2008) Strictosidine Synthase: Mechanism of a Pictet-
Spengler catalyzing enzyme. J. Amer. Chem. Soc. 130, 710-723.
• Yerkes, N., Wu, J., McCoy, E., Galan, M. C., Chen, S., O’Connor, S. E. (2008)
Substrate specificity and diastereoselectivity of strictosidine glucosidase.
Biorg. Med. Chem. Lett. 18, 3095-3098.
•O’Connor, S. E. (2008) Alkaloid Biosynthesis. in: Encyclopedia of Chemical
Biology. WileyBlackwell, T. Begley Ed.
• McCoy, E., O’Connor, S. E. (2007) Natural products from plant cell culture. Natural Products as Drugs, F. Peterson, Ed. Verlag AG.
• Galan, M. C., McCoy, E., O'Connor, S. E. (2007) Chemoselective derivatization of unnatural alkaloids in periwinkle. Chem. Comm. 3249-3251.
• Bernhardt, P., McCoy, E., O’Connor, S. E. (2007) Rapid identification of enzyme variants for reengineered alkaloid biosynthesis in periwinkle. Chem. Biol. 14, 888-897.
• Chen, S.*, Galan, M. C.*, Carla Coltharp, O'Connor, S. E. Redesign of a central enzyme in alkaloid biosynthesis. (2006) Chem. Biol. 13, 1137-1141.
* denotes equal authorship
• McCoy, E., O'Connor, S. E. Precursor directed biosynthesis of alkaloids in periwinkle. (2006) J. Amer. Chem. Soc. 128, 14276-14277.
• O'Connor, S. E., Maresh, J. M. (2006) Chemistry and biology of terpene indole alkaloid biosynthesis. Nat. Prod. Rep. 23, 532-547.
• Galan, M. C., O'Connor, S. E. (2006) Semisynthesis of secologanin derivatives. Tetrahedron Lett. 47, 1563-1565.
• McCoy, E., Galan, M. C., O'Connor, S. E. (2006) Substrate specificity of strictosidine synthase. Bioorg. Med. Chem. Lett. 16, 2475-2478.
•O'Connor, S. E., McCoy, E. M. (2006) Terpene indole alkaloid biosynthesis. Rec.
Adv. Phytochem. 40, 1-22.