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Main Laboratories and Facilities Equipment

(6-008, Ramachandra R. Dasari)

Fast and reliable intra-operative diagnosis is a critical component of successful oncological surgery in a variety of organ systems. While optical probe and in vivo imaging strategies have been proposed by us and others as potential tools for surgical margin assessment, there continues to exist a significant clinical need for rapid and reliable evaluation of excised tissues in real time. In this work, however, we are developing a new and complementary strategy to enable real-time comprehensive assessment of surgical margins in excised tissues. While in vivo imaging remains a highly desirable research ideal, short-term clinical benefits are much more likely to result from ex vivo systems that are capable of imaging excised tissues at high resolution, free of motion artifacts, blood and other clinical constraints commonly imposed on operative tools that come in contact with the patient. Specifically, the instrument is a wide-area spectroscopic scanner, capable of multi-modal quantitative spectroscopy at high resolution. As such, large surgical margins, such as the entire surface of an excised breast lesion, can be quantitatively assessed in real-time.

Ex-vivo optical bench scanner
2-D mechanical scanning (M-605.1DD and M-126.DG1, Physik Instrument)
Xenon arch lamp (oriel) 500W
White light LED source (CCD PSB-1012V-WW)
XY High speed steering mirror
Spectrograph (Acton Standard Series SP-2150i)
CCD Camera (Photon Max 512)

Ex-vivo table top scanner
Miniature xenon arc lamp 55W
Pulsed diode pumped solid state laser (SNV-40F-000, Teem Photonics).
Dual axes translation stage : Advance tech – max travel distance ~ 10 inch x 10 inch
Spectrometer (USB 2000+, Ocean Optics)