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Year: | 2005 | ||||
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Type of Publication: | Article | ||||||
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Journal: | Nature Materials | Volume: | 4 | ||||
Number: | 1 | Pages: | 86-U16 | ||||
Month: | JAN 2005 | ||||||
Note: | PT: J; TC: 373; UT: WOS:000226113600022 |
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Abstract: | Molecular detection using near-infrared light between 0.9 and 1.3 eV has important biomedical applications because of greater tissue penetration and reduced autofluorescent background in thick tissue or whole-blood media. Carbon nanotubes have a tunable near-infrared emission that responds to changes in the local dielectric function but remains stable to permanent photobleaching. In this work, we report the synthesis and successful testing of solution-phase, near-infrared sensors, with beta-D-glucose sensing as a model system, using single-walled carbon nanotubes that modulate their emission in response to the adsorption of specific biomolecules. New types of non-covalent functionalization using electron-withdrawing molecules are shown to provide sites for transferring electrons in and out of the nanotube. We also show two distinct mechanisms of signal transduction - fluorescence quenching and charge transfer. The results demonstrate new opportunities for nanoparticle optical sensors that operate in strongly absorbing media of relevance to medicine or biology. |
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