Reactive Oxygen Species Driven Angiogenesis by Inorganic Nanorods

BibTex:
Research areas:	Uncategorized	Year:	2011
Type of Publication:	Article
Authors:	Chitta Ranjan Patra, Kallal Pramanik Jong-Ho Kim Uscio, Krishnendu Pal Sujata Patra
Journal:	Nano Letters	Volume:	11
Number:	11	Pages:	4932-4938
Month:	NOV 2011

@article{RefWorks:420, author = "Chitta Ranjan Patra,Jong-Ho Kim,Kallal Pramanik,Livius V. d{\&}#039 and Uscio,Sujata Patra,Krishnendu Pal,Ramani Ramchandran,Michael S. Strano,Debabrata Mukhopadhyay", abstract = "The exact mechanism of angiogenesis by europium hydroxide nanorods was unclear. In this study we have showed that formation of reactive oxygen species (H(2)O(2) and O(2)center dot-) is involved in redox signaling pathways during angiogenesis, important for cardiovascular and ischemic diseases. Here we used single-walled carbon nanotube sensor array to measure the single-molecule efflux of H(2)O(2) and a HPLC method for the determination of O(2)center dot- from endothelial cells in response to proangiogenic factors. Additionally, reactive oxygen species-mediated angiogenesis using inorganic nanorods was observed in transgenic (flila:EGFP) zebrafish embryos.", isbn = "1530-6984", journal = "Nano Letters", month = "NOV 2011", note = "PT: J; TC: 0; UT: WOS:000296674700075", number = "11", pages = "4932-4938", title = "{R}eactive {O}xygen {S}pecies {D}riven {A}ngiogenesis by {I}norganic {N}anorods", volume = "11", year = "2011", }
Note:	PT: J; TC: 0; UT: WOS:000296674700075
Abstract:	The exact mechanism of angiogenesis by europium hydroxide nanorods was unclear. In this study we have showed that formation of reactive oxygen species (H(2)O(2) and O(2)center dot-) is involved in redox signaling pathways during angiogenesis, important for cardiovascular and ischemic diseases. Here we used single-walled carbon nanotube sensor array to measure the single-molecule efflux of H(2)O(2) and a HPLC method for the determination of O(2)center dot- from endothelial cells in response to proangiogenic factors. Additionally, reactive oxygen species-mediated angiogenesis using inorganic nanorods was observed in transgenic (flila:EGFP) zebrafish embryos.

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