Reactive Oxygen Species Driven Angiogenesis by Inorganic Nanorods

Research areas:
  • Uncategorized
Year: 2011
Type of Publication: Article
  • Chitta Ranjan Patra, Kallal Pramanik Jong-Ho Kim
  • Uscio, Krishnendu Pal Sujata Patra
Journal: Nano Letters Volume: 11
Number: 11
Month: NOV 2011
PT: J; TC: 2; UT: WOS:000296674700075
The exact mechanism of angiogenesis by europium hydroxide nanorods was unclear. In this study we have showed that formation of reactive oxygen species (H(2)O(2) and O(2)center dot-) is involved in redox signaling pathways during angiogenesis, important for cardiovascular and ischemic diseases. Here we used single-walled carbon nanotube sensor array to measure the single-molecule efflux of H(2)O(2) and a HPLC method for the determination of O(2)center dot- from endothelial cells in response to proangiogenic factors. Additionally, reactive oxygen species-mediated angiogenesis using inorganic nanorods was observed in transgenic (flila:EGFP) zebrafish embryos.