Microfabricated
Devices for Biomolecular Detection
MIT
- Assistant Professor of Media Arts and
Sciences
Background
Papers for Talk:
Translating
Biomolecular Recogntion into Nanomechanics Fritz, et al. Science 2000
Systems
Biology A Brief Overview. Kitano. Science 2002
We are developing real-time
and quantitative measurement techniques for extracting information from
biological systems. Our
ultimate goal is to provide an instantaneous readout of a
multi-dimensional parameter space, which is critical for furthering our
understanding of biological processes, and ultimately advancing our
health. However, the sample
preparation and large sample volumes required for current methodology
limits the rate at which data is acquired.
As a result, the labor and cost required to collect even a single
parameter set can represent a substantial bottleneck.
In this talk I will present
recent developments of mechanical and electrical detectors for measuring
the interactions of unlabeled biomolecules, the real-time detection of DNA
using silicon field-effect detection, and the integration of mechanical
and electrical detectors with microfluidics.
|
Scott R. Manalis received the B.S.
degree in physics from the University of California, Santa Barbara
in 1994, and the Ph.D. degree in applied physics from Stanford
University, Palo Alto, CA in 1998.
Currently, he is an Assistant
Professor of Media Arts & Sciences and Biological Engineering
at the Massachusetts Institute of Technology (MIT). His research
interests are on the development of nanofabrication technologies
for building molecular-scale devices, the use of MEMS for novel
detection schemes, and the application of such devices to biology.
Dr. Manalis was the recipient of the Presidential Early Career
Award for Scientists and Engineers (PECASE) from the Department of
Defense.
|
|
