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Selected Reagents and Materials for Non-Exclusive Licensing

Monoclonal Antibodies Against CPG2

MIT Case No. 11621
Jeffrey Cottrell and Elly Nedivi.

3 separate clones of monoclonal antibodies against the mouse and rat CPG2 protein, the product of the cpg2 transcript (regulated by neuronal activity).  CPG2 protein is localized to postsynaptic sites on excitatory neurons (mostly spine synapses). 
200A5: IgG2a
200A6: IgG1
200A9: IgG2a

Antibody Against Mouse HRI-Nterminus Domain

MIT Case No. 11585
Jane-Jane Chen

Polyclonal antibody against mouse HRI-Nterminus domain.
HRI, the heme-regulated translational inhibitor, is a heme-regulated protein kinase that phosphorylates the alpha-subunit of eukaryotic translational initiation factor 2 (eIF2a).  This phosphorylation of eIF2a prevents the recycling of eIF2 for another round of translational initiation, and thus inhibits protein synthesis.  HRI is critical in the production of hemoglobin and red blood cells, and is present in all vertebrates.  The N-terminus is highly conserved among different species.  This domain binds heme and is essential for efficient down-regulation of HRI activity by heme.

Inducible Gene Expression System

MIT Case No. 9796
Nico Callewaert, Roland Contreras, Gobind Khorana and Phil Reeves

Cell line for expressing high levels of a protein of interest in a cell. In particular, protein could be a) toxic to cells or b) a glycoprotein, such as a membrane protein.  Cell line has been mutated to inactivate N-acetylglucosamine transferase I to ensure uniform glycosylation.  Such post-translational modifications may make the produced proteins more acceptable to humans than those from other systems because it helps insure correct folding.