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ANDREI TOKMAKOFF - CURRICULUM VITAE

Department of Chemistry, Room 6-213
Massachusetts Institute of Technology
Cambridge, MA 02139
Tel: 617-253-4503
Fax: 617-253-7030
E-mail: tokmakof@mit.edu

 
PROFESSIONAL EXPERIENCE

 
2007– Professor of Chemistry, Massachusetts Institute of Technology
2003–07 Associate Professor of Chemistry, Massachusetts Institute of Technology
1998–03 Assistant Professor of Chemistry, Massachusetts Institute of Technology
1996–98 National Science Foundation Postdoctoral Research Fellow with Prof. Graham Fleming. Department of Chemistry and the James Franck Institute, University of Chicago (1996-97) Department of Chemistry, University of California, Berkeley; and Lawrence Berkeley National Laboratory (1997-98)
1995–96 Alexander von Humboldt Research Fellow with Prof. Alfred Laubereau. Department of Physics, Technical University, Munich

 
EDUCATION

 
1995 Ph.D. in Chemistry, Stanford University
Research Advisor: Michael D. Fayer
1991 M.S. in Chemistry, Stanford University
1988 B.S. in Chemistry, California State University, Sacramento

 
AWARDS AND HONORS

 
2012 Earle K. Plyler Prize for Molecular Spectroscopy & Dynamics (American Physical Society)
2009 Fellow of the Optical Society of America
2009 Peter B. Sherry Memorial Lecture, Georgia Institute of Technology
2003 Bryce Crawford Jr. Lecturer, University of Minnesota
2002 National Fresenius Award (Phi Lambda Upsilon)
2002 Alfred P . Sloan Research Fellowship
2002 Coblentz Award (Coblentz Society)
2001 Richard E. Heikkila Research Scholar Award (National Parkinson Foundation)
2001 Outstanding Young Investigator (Time-Resolved Vibrational Spectroscopy Conference)
2000 David and Lucile Packard Fellowship for Science and Engineering
1999 Research Corporation Research Innovation Award
1995 National Science Foundation Postdoctoral Fellowship in Chemistry
1994 Alexander von Humboldt Foundation Research Fellowship

 
PRINCIPAL RESEARCH INTERESTS

 
Molecular dynamics in solution. Development of experimental methods to study transient molecular structure and its time-evolution in molecular condensed phases and biological systems. Study of water: structure, dynamics, and hydrophobicity. Study of chemical reactions in solution. Conformation and dynamics of peptides and proteins. Dynamics of protein folding and binding. Molecular recognition and self-assembly. Mechanics of bio-inspired polymers. Development of two-dimensional vibrational spectroscopies. Development of methods for generating, characterizing and femtosecond infrared electric fields. Theory and simulation of molecular dynamics for interpreting nonlinear spectroscopies. Quantum mechanics, statistical mechanics, and spectroscopy of disordered systems and collective excitations.

 
PROFESSIONAL ACTIVITIES

 
1998 Frontiers in Science Symposium, National Academy of Sciences, Irvine, CA
1999 Department of Energy Site Review Panel, Chemical Sciences Division, Argonne National Laboratory
2002 DOE Workshop on Electron Initiated Processes and Radical Chemistry in Water, Richland, WA
2004 Symposium Organizer, Nonlinear Spectroscopy of Chemical and Biological Dynamics, OSA Frontiers in Optics/Laser Science Meeting, Rochester, NY
2004-2008 Program Committee, International Conference on Ultrafast Phenomena
2004-pres. Organizing Committee, International Conference on Coherent Multidimensional Spectroscopy
2005 Symposium Co-Organizer, Dynamics in Condensed Phases, APS National Meeting, Los Angeles, CA
2005-pres. Organizing Committee, International Conference on Time-Resolved Vibrational Spectroscopy
2007- Editorial Committee, Advances in Chemical Physics
2007-2012 Editorial Committee, Annual Reviews of Physical Chemistry
2008 Symposium Co-Organizer, Optical Probes of Dynamics in Complex Environments, ACS National Meeting, New Orleans, LA
2008 NIH Special Emphasis Panel ZRG1 BCMB-N
2008-2010 Editorial Committee, Journal of Chemical Physics
2008-2011 Scientific Advisory Committee, Munich-Centre for Advanced Photonics
2009 Conference Chair, Fourteenth International Conference on Time-Resolved Vibrational Spectroscopy (TRVS XIV), Meredith, NH
2009 Department of Energy SISGR Review Panel (Single Investigators and Small Groups)
2009 Organizing Committee, International Conference on Transient Chemical Structures in Dense Media
2010 NIH Special Emphasis Panel/Scientific Review Group MSFB
2010-2012 OSA Ellis Lippincott Award Committee
2011-2015 Scientific Advisory Committee, Max-Born-Institute, Berlin, Germany
2011 Department of Energy Early Career Program Review Panel
2011 Visiting Member, NIH MSFB Study Section

 
REPRESENTATIVE PUBLICATIONS (of 127)

  • “Vibrational anharmonicities revealed by coherent two-dimensional infrared spectroscopy,”
    O. Golonzka, M. Khalil, N. Demirdöven and A. Tokmakoff, Physical Review Letters, 86, 2154 (2001).

  • “Coupling and orientation between vibrations characterized with two-dimensional IR vibrational echo spectroscopy,” O. Golonzka, M. Khalil, N. Demirdöven, A. Tokmakoff, J. Chem. Phys., 115, 10814 (2001).

  • “Coherent 2D IR Spectroscopy: Molecular structure and dynamics in solution,” M. Khalil, N. Demirdöven and A. Tokmakoff, Journal of Physical Chemistry A, 107, 5258 (2003).

  • “Ultrafast hydrogen bond dynamics in the infrared spectroscopy of water,” C. J. Fecko, J. D. Eaves, J. J. Loparo, A. Tokmakoff and P. G. Geissler, Science, 301, 1698 (2003).

  • “Signatures of β–sheet secondary structures in linear and two-dimensional infrared spectroscopy,” C. M. Cheatum, A. Tokmakoff, and J. Knoester, J. Chem. Phys., 120, 8201 (2004).

  • “Two-dimensional infrared spectroscopy of antiparallel β–sheet secondary structure,” N. Demirdöven, C. M. Cheatum, H.-S. Chung, M. Khalil, J. Knoester and A. Tokmakoff, J. Am. Chem. Soc., 126, 7981 (2004).

  • “Local hydrogen bonding dynamics and collective reorganization in water: Ultrafast IR spectroscopy of HOD/D2O,” C. J. Fecko, J. J. Loparo, S. T. Roberts and A. Tokmakoff, J. Chem. Phys., 122, 054506 (2005).

  • “Conformational changes during the nanosecond to millisecond unfolding of ubiquitin,” H.–S. Chung, M. Khalil, A. W. Smith, Z. Ganim and A. Tokmakoff, Proc. Nat’l Acad. Sci., USA, 102, 612 (2005).

  • “Hydrogen bonds in liquid water are broken only fleetingly,” J. D. Eaves, J. J. Loparo, C. J. Fecko, S. T. Roberts, A. Tokmakoff and P. L. Geissler, Proc. Nat’l Acad. Sci., USA, 102, 13019 (2005).

  • “Polarizable molecules in the vibrational spectroscopy of water,” E. Harder, J. D. Eaves, A. Tokmakoff and B. J. Berne, Proc. Nat’l Acad. Sci., USA, 102, 11611 (2005).

  • “Visualization and characterization of the infrared active amide I vibrations of proteins,” H. S. Chung and A. Tokmakoff, J. Phys. Chem. B, 110, 2888 (2006).

  • “Spectral signatures of heterogeneous protein ensembles revealed by MD simulations of 2D IR spectra,” Z. Ganim and A. Tokmakoff, Biophysical Journal, 91, 2636 (2006).

  • “Multidimensional infrared spectroscopy of water. II. Hydrogen bond switching dynamics,” J. J. Loparo, S. T. Roberts, and A. Tokmakoff, Journal of Chemical Physics, 125, 194522 (2006).

  • “Water penetration into protein secondary structure revealed by hydrogen-deuterium exchange 2D IR spectroscopy,” L. P. DeFlores and A. Tokmakoff, J. Am. Chem. Soc., 128, 16520 (2006).

  • “Probing local structural events in β–hairpin unfolding with transient nonlinear infrared spectroscopy,” A. W. Smith and A. Tokmakoff, Angewandte Chemie, International Edition, 46, 7984 (2007).

  • “Transient 2D IR spectroscopy of ubiquitin unfolding dynamics,” H. S. Chung, Z. Ganim, K. C. Jones, and A. Tokmakoff, Proc. Nat’l Acad. Sci., USA, 104, 14237 (2007).

  • “A transient 2D IR spectrometer for probing nanosecond temperature-jump kinetics,” H. S. Chung, M. Khalil, A. W. Smith and A. Tokmakoff, Rev. Sci. Instrum., 78, 063101 (2007).

  • “Shining Light onto Water’s Rapidly Evolving Structure,” (Perspective) A. Tokmakoff, Science, 317, 54 (2007).

  • “Amide I two-dimensional infrared spectroscopy of proteins,” Z. Ganim, H. S. Chung, A. W. Smith, L. P. DeFlores, K. C. Jones, and A. Tokmakoff, Acc. Chem. Res., 41, 432 (2008).

  • “Amide I′-II′ 2D IR spectroscopy provides enhanced protein secondary structural sensitivity,” L. P. DeFlores, Z. Ganim, R. A. Nicodemus, and A. Tokmakoff, J. Am. Chem. Soc., 131, 3385 (2009).

  • “Observation of a Zundel-like transition state during proton transfer in aqueous hydroxide solutions,” S. T. Roberts, P. B. Petersen, K. Ramasesha, A. Tokmakoff, I. S. Ufimtsev, and T. J. Martinez, Proc. Nat. Acad. Sci., 106(36) 15154 (2009).

  • “Structural Rearrangements in Water Viewed Through Two-Dimensional Infrared Spectroscopy,” S. T. Roberts, K. Ramasesha and A. Tokmakoff, Acc. Chem. Res., 42(9), 1239 (2009).

  • “Source for ultrafast continuum infrared and terahertz radiation,” P. Petersen and A. Tokmakoff, Optics Letters, 35(12), 1962 (2010).

  • “Ultrafast 2D IR Anisotropy of Water Reveals Reorientation during Hydrogen-Bond Switching,” K. Ramasesha, S. T. Roberts, R. A. Nicodemus, A. Mandal and A. Tokmakoff, J. Chem. Phys., 135, 054509 (2011).

  • “Anharmonic Vibrational Modes of Nucleic Acids Bases Revealed by 2D IR Spectroscopy,” C. S. Peng, K. C. Jones, and A. Tokmakoff, J. Am. Chem. Soc., 133, 1565 (2011).