Inflammation-related protein and DNA damage. My principal research interests reside in how the chemistry and biology of inflammation contributes to the etiology of cancer and in the discovery and evaluation of biomarkers that predict disease onset. I am currently applying analytical mass spectrometry and proteomics techniques to uncover protein targets and modified-amino acids from the serum of patients with inflammatory bowel disease (Crohn’s Disease and Ulcerative Colitis). Additionally, I am investigating the kinetic and thermodynamic equilibria of protein S-nitrosation reactions (posttranslational modification of nitric oxide to cysteine residues) to better understand intracellular regulatory mechanisms. The biological processing (biotransformation, transport, and elimination) of endogenous DNA adducts is also of interest.

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