Selected and recent publications.

Kun Lu, Ridwan Mahbub, Peter Hans Cable, Hongyu Ru, Nicola M. A. Parry, Wanda M. Bodnar, John S. Wishnok, Miroslav Styblo, James A. Swenberg , James G. Fox, and Steven R. Tannenbaum. 2014. Gut microbiome phenotypes driven by host genetics affect arsenic metabolism. Chem. Res. Toxicol., 27 (2), 172174 PMID: 24490651

Kun Lu, Ryan Phillip Abo, Katherine Ann Schlieper, Michelle E. Graffam, Stuart Levine, John S. Wishnok, James A. Swenberg, Steven R. Tannenbaum, and James G. Fox. 2014. Arsenic exposure perturbs the gut microbiome and its metabolic profile in mice: an integrated metagenomics and metabolomics analysis.Environ Health Perspect. Mar 2014; 122(3): 284291. PMID: 24413286

Yong-Ak Song, Lidan Wu, Steven R. Tannenbaum , John S. Wishnok, and Jongyoon Han. 2013. Tunable membranes for free-flow zone electrophoresis in PDMS microchip using guided self-assembly of silica microbeads. Anal Chem. Dec 17;85 (24):11695-11699. doi: 10.1021/ac402169x. Epub 2013 Nov 25. PMID: 24251795

Kun Lu, Peter Hans Cable, Ruam Phillip Abo, Hongyu Ru, Michelle E. Graffam, Katherine Ann Schlieper, Nocola M.A. Parry, Stuart Levine, Wanda Bodnar, John S. Wishnok, Miroslav Stblo, James A. Swenberg, James G. Fox, and Steven R. Tannenbaum. 2013. Gut microbiome perturbations induced by bacterial infection affect arsenic biotransformation. Chem. Res. Toxicol., 26 (12), 18931903 PMID: 4134150.

Charles G. Knutson, Aswin Mangerich, Yu Zeng, Arek R. Raczynski, Rosa G. Liberman, Pilsoo Kang, Wenjie Ye, Erin Prestwich, Kun Lu, John S. Wishnok, Joshua R. Korzenik, Gerald N. Wogan, James G. Fox, Peter C. Dedon, and Steven R. Tannenbaum. (2013) Chemical and cytokine features of innate immunity characterize serum and tissue profiles in inflammatory bowel disease. Proc. Natl Acad. Sci. USA, 110, E332-331 . PMID: 23754421

Uthpala Seneviratne, Luiz Godoy, John S. Wishnok, Gerald N. Wogan, and Steven R. Tannenbaum. (2013) Mechanism-based triarylphosphine-ester probes for capture of endogenous RSNOs. J. Amer. Chem. Soc., 135, 7693-7704. PMID: 23614769

Kok Seong Lim, Liang Cui, Koli Taghizadeh, John S. Wishnok, Wan Chan, Michael S. DeMott, I. Ramesh Babu, and Peter C. Dedon. (2013) In Situ Analysis of 8-Oxo-7,8-dihydro-2'-deoxyguanosine Oxidation Reveals Sequence- and Agent-Specific Damage Spectra.
J. Am. Chem. Soc., 134, 18053-18064 . PMID: 3057664. PMCID: PMC3503518

Liang Cui , Wenjie Ye, Erin Prestwich, John S. Wishnok, Koli Taghizadeh, Peter C. Dedon, and Steven R. Tannenbaum. (2012) Comparative analysis of four oxidized guanine lesions from reactions of DNA with peroxynitrite, singlet oxygen and ?-radiation. Chem. Res. Toxicol., 26, 195-202. PMID: 3140136. PMCID: PMC3578445

Kun Lu, Charles G. Knutson, John S. Wishnok, James G. Fox, and Steven R.Tannenbaum. (2012) Serum metabolomics in a Helicobacter hepaticus mouse model of inflammatory bowel disease reveal important changes in the microbiome, Serum Peptides, and Intermediary Metabolism. J. Proteome Res., 11, 4916-4926. PMID: 22957933.

Aswin Mangerich, Charles G. Knutson, Nicola M. Parry, Sureshkumar Muthupatiani, Wenjie Ye, Erin Prestwich, Liang Cui, Jose L. McFaline, Melissa Mobley, Zhongming Ge, Koli Taghizadeh, John.S.Wishnok, Gerald N. Wogan, James G. Fox, Steven R. Tannenbaum, and Peter.C. Dedon. 2012. Infection-induced colitis in mice causes dynamic and tissue-specific changes in stress response and DNA damage leading to colon cancer. Proc. Natl. Acad. Sci. USA, 109, E1820-E1829. [Epub ahead of print]. PMID:22689960.

Kok Seong Lim, Koli Taghizadeh, John S. Wishnok, Ramesh Babu Indrakanti, Vladimir Shafirovich, Nicholas E. Geacintov, and Peter C. Dedon. 2012. Sequence-dependent variation in the reactivity of 8-oxo-7,8-dihydro-2'-deoxyguanosine toward oxidation. Chem. Res. Toxicol., 25, 366-373. PMID: 22103813.

Katherine T. Barglow, Charles G. Knutson, John S. Wishnok, Steven R.Tannenbaum, and Michael A. Marletta. 2011. Site-specific and redox-controlled S-nitrosation of thioredoxin. Proc. Natl. Acad. Sci.USA;108, E600-E606. PMID:21849622.

Peter G. Slade, Michelle V. Williams, Alison Chiang, Elizabeth Iffrig, John S. Wishnok, and Steven R. Tannenbaum. 2011. A filtered database search algorithm for endogenous serum protein carbonyl modifications in a mouse model of inflammation. Mol. Cell. Proteomics, 10, M111.007658. PMID:21768395.

Trista E. North, I. Ramesh Babu, Lea M. Vedder, Allegra M. Lord, John S. Wishnok, Steven R. Tannenbaum, Leonard I. Zon, and Wolfram Goessling. 2010. PGE2-regulated wnt signaling and N-acetylcystein are synergisticallyt hepatoprotective in zebrafish aceaminophen injury. Proc. Nat'l. Acad. US., 107, 17315-17320.

Yong-Ak Song, Michael Chan, Chris Celio, Steven R. Tannenbaum, John S. Wishnok, and Jongyoon Han. 2010. Free-flow zone electrophoresis of peptides and proteins in PDMS microchip for narrow pI range sample prefractionation coupled with mass spectrometry. Anal. Chem., 82, 2317-2325.

Peter G. Slade, Michelle V. Williams, Viral Brahmbhatt, Ajit Dash, John S. Wishnok, and Steven R. Tannenbaum. 2010. Proteins Modified the lipid peroxidation aldehyde 9,12-dioxo-!0(E)-dodecenoic acid in MCF7 breast cancer cells. Chem. Res. Toxicol., 23, 557-567.

Paul L. Skipper, Min Young Kim, H.-L. Patty Sun, Gerald N. Wogan, and Steven R. Tannenbaum. 2010. Monocyclic aromatic amines as potential human carcinogens: old is new again. Carcinogenesis, 31, 50-58.

Dora Il'yasova, Bridget J. McCarthy, Serap Erdal, Joanna Shimek, Jennifer Goldstein, Daniel R. Doerge, Steven R. Myers, Paolo Vineis, John S. Wishnok, James A. Swenberg, Darrell D. Bigner, and Faith G. Davis. 2009. Human exposure to selected animal neurocarcinogens: a biomarker-based assessment and implications for brain tumor epidemiology. J. Toxicol. Environ. Health B. Crit. Rev., 12, 175-187.

Anna L. Stevens, John S. Wishnok, Forest M. White, Alan J. Grodzinsky, and Steven R. Tannenbaum. 2009. Mechanical injury and cytokines cause loss of cartilage integrity and upregulate proteins associated with catabolism, immunity, inflammation, and repair. Mol. Cell Proteomics, 8, 1475-1489.

Anna L. Stevens, John S. Wishnok, Diana H. Chai, Alan J. Grodzinsky, and Steven R. Tannenbaum. 2008. A sodium dodecyl sulfate-polyacrylamide gel electrophoresis-liquid chromatography tandem mass spectrometry analysis of bovine cartilage tissue response to mechanical compression injury and the inflammatory cytokines tumor necrosis factor a and interleukin-1ß. Arthritis Rheum., 58, 489-500.

Michelle V. Williams, John S. Wishnok, and Steven R. Tannenbaum. 2007. Covalent adducts arising from the decomposition products of lipid hydroperoxides in the presence of cytochrome C. Chem. Res. Toxicol., 20, 767-775.

Lianrong Wang, S. Chen , T. Xu, Koli Taghizadeh, John S. Wishnok, Xinfeng Zhou, D. You, Z. Deng, and Peter C. Dedon. 2007. Phosphorothioation of DNA in bactera by dnd genes. Chem. Res. Toxicol., 20, 1730-1736.

Monica Kristiansson, Vadiraja Bhat, I. Ramesh Babu, John S. Wishnok, and Steven R. Tannenbaum. Comparative time-dependent analysis of potential inflammation biomarkers in lymphoma-bearing SJL mice. J. Proteome Res., 6, 1735-1744 (2007).

Bo Pang, Xinfeng Zhou, Hongbin Yu, Min Dong, Koli Taghizadeh, John S. Wishnok, Steven R. Tannenbaum, and Peter C. Dedon. Lipid peroxidation dominates the chemistry of DNA adduct formation in a mouse model of inflammation. Carcinogenesis, 28, 1807-1813 (2007).

Michelle V. Williams, John S. Wishnok, and Steven R. Tannenbaum. Covalent adducts arising from the decomposition products of lipid hydroperoxides in the presence of cytochrome C. Chem. Res. Toxicol., 20, 767-775 (2007).

Beatriz Zayas, W.G. Stillwell, John S. Wishnok, Laura J. Trudel, Paul L. Skipper, John M. Essigmann, and Robert G. Croy. Detection and quantification of 4-ABP adducts in DNA from bladder cancer patients. Carcinogenesis., 28, 342-349 (2007).

Shawn M. Hillier, John C. Marquis, Beatriz Zayas, John S. Wishnok, Rosa G. Liberman, Paul L. Skipper, Steven R. Tannenbaum, John M. Essigmann, and Robert G. Croy. DNA adducts formed by a novel antitumor agent 11beta-dichloro in vitro and in vivo. Mol. Cancer Ther., 5, 977-984 (2006).

Hyun Gyung Jang, Misun Park, John S. Wishnok, Steven R. Tannenbaum, and Gerald N. Wogan. Hydroxyl specific fluorescence labeling of ABP-deoxyguanosine, PhIP-deoxyguanosine, and AFB1-formamidopyrimidine with BODIPY-FL. Anal. Biochem., 359, 151-160 (2006).

Jacquin C. Niles, John S. Wishnok and Steven R. Tannenbaum. Peroxynitrite-induced oxidation and nitration products of guanine and 8-oxoguanine: structures and mechanisms of product formation. Nitric Oxide, 14, 109-121 (2006).

Alex Garcia, Carlos J. Bosques, John S. Wishnok, Yan Feng, B.J. Karalius, J.R. Butterton, David B. Schauer, Arlin B. Rogers, and James G. Fox. Renal injury is a consistent finding in Dutch Belted rabbits experimentally infected with enterohemorrhagic Escherichia coli. J. Infect. Disease., 193, 1125-1134 (2006).

Barbara J. Hughey, Paul L. Skipper, John S. Wishnok, Ruth E. Shefer, Naomi A. Fried, John T. Mehl, and Steven R. Tannenbaum. Sample introduction interface for analytical processing. U.S. Patent No. 6,867,415.

Barbara J. Hughey, Paul L. Skipper, John S. Wishnok, Ruth E. Shefer, John T. Mehl, and Steven R. Tannenbaum. Sample Introduction Interface for Analytical Processing of a Sample Placed on a Substrate. U.S. Patent No. 6,707,035

Vadiraja B. Bhat, Man Ho Choi, J.S. Wishnok, and Steven R. Tannenbaum. Comparative plasma proteome analysis of lymphoma-bearing SJL mice. J. Proteome. Res., 4, 1814-1825 (2005).

Hongbin Yu, Lata Venkatarangan, John S. Wishnok, and Steven R. Tannenbaum. Quantitation of four oxidation products from reaction of DNA with varying doses of peroxynitrite. Chem. Res. Toxicol., 18, 1849-1857 (2005).

James C. Delaney, Lisa Smeester, C. Wong, Koli Taghizadeh, John S. Wishnok, Catherine L. Drennan, Leona D. Samson, and John M. Essigmann. AlkB reverses DNA damage caused by lipid oxidation in vitro and in vivo. Nature Struct. Molecul. Biol., 18, 855-860 (2005).

Man Ho Choi, Paul L. Skipper, John S. Wishnok, and S.R. Tannenbaum. Characterization of testosterone 11-[beta]-hydroxylation catalyzed by human liver cytochromes P450. Drug Metab. Dispos., 33, 714-8 (2005).

Dora Farkas, Vadiraja B. Bhat, Saraswathi Mandapati, John S. Wishnok, and Steven R. Tannenbaum. Characterization of the secreted proteome of rat hepatocytes cultured in collagen sandwiches. Chem. Res. Toxicol., 18, 1132-1139 (2005).

Jacquin Niles, John S.Wishnok and Steven R. Tannenbaum. Spiroiminodihydantoin and guanidinohydantoin are the dominant products of 8-oxoguanosine oxidation at low fluxes of peroxynitrite: kinetic and mechanistic studies with 18O. Chem. Res. Toxicol. 17, 1510-1519 (2004).

Jacquin C. Niles, John S.Wishnok and Steven R. Tannenbaum. Mass Spectrometric Identification of 4-hydroxy-2,5-dioxo-imidazolidine-4-carboxylic acid during Oxidation of 8-oxoguanosine by Peroxynitrite and KHSO5/CoCl2. Chem. Res. Toxicol. 17, 1501-1509 (2004).

Hongbin Yu, Jacquin C. Niles, John S. Wishnok, Steven R.Tannenbaum. Spirodihydantoin is a minor product of 5-hydroxyisourate in urate oxidation. Org Lett. 6, 3417-3420 (2004).

Paul L. Skipper, Barbara J. Hughey, Rosa G. Liberman, M.H. Choi, John S. Wishnok, Robert E. Klinkowstein, Ruth E. Shefer, and Steven R. Tannenbaum. Bringing AMS into the Bioanalytical Chemistry Lab. IN: Nuclear Instruments and Methods in Physics Research ? B. Proceedings of the AMS-9 Conference. Nucl. Instr. Meth .Phys. Res. B. 223-224, 740-744 (2004).

Hongbin Yu, John S. Wishnok, and S Tannenbaum. Synthesis of 3,7,8, 15N3-N1-(B-D-eryt-hro-pentofuranosyl)-5-guanidinohydantoin., J. Labelled Compnds Radiopharm. 46, 1269-1277 (2003)

Jennifer L. Caulfield, John S. Wishnok, and Steven R. Tannenbaum. Nitric oxide-induced interstrand cross-links in DNA. Chem Res Toxicol., 16 571-574, (2003).

Feng Gu, Sara Stillwell, John S. Wishnok, Anthony J. Shallop, Roger A. Jones, and Steven R. Tannenbaum. Peroxynitrite-induced reactions of synthetic oligo 2'-deoxynucleotides and DNA containing guanine: formation and stability of a 5-guanidino-4-nitroimidazole lesion. Biochemistry, 23, 7508-7518. (2002).

Joseph M. Lee, Jacquin C. Niles, John S. Wishnok, and Steven R. Tannenbaum. Peroxynitrite reacts with 8-nitropurines to yield 8-oxopurines. Chem Res Toxicol., 15, 7-14 (2002).

Jacquin C. Niles, John S. Wishnok, and Steven R. Tannenbaum. A novel nitroimidazole compound formed during the reaction of peroxynitrite with 2?,3?,5?-tri-O-acetyl-guanosine. J. Am. Chem. Soc., 49, 12147-12151 (2001).

John T. Mehl, Paul L. Skipper, Steven R. Tannenbaum, John S. Wishnok, Barbara J. Hughey, Robert E. Klinkowstein, and Ruth E. Shefer. GC and LC interfaces for biological AMS. in Synthesis and Applications of Isotopes and Isotopically Labelled Compounds 2001, U. Pleis and R. Voges, eds., Proceedings of the 7th International Symposium on the synthesis and applications of isotopes and isotopically labelled compounds, Dresden, Germany, June 2000. John Wiley and Sons, Hoboken. (2001).

Kaisheng Jiao, Saraswathi Mandapati, Paul L. Skipper, Steven R. Tannenbaum, and John S. Wishnok. Site-selective nitration of tyrosine in human serum albumin by peroxynitrite. Anal. Biochem., 293, 43-52 (2001).

Natalia Tretyakova, Brock Matter, Alexis Ogdie, John S. Wishnok, and Steven R. Tannenbaum. Locating nucleobase lesions within DNA sequences by MALDI-TOF mass spectral analysis of exonuclease ladders. Chem. Res. Toxicol., 14, 1058-1070 (2001).

Kaushik Mitra, John C. Marquis, Shawn Hillier, Peter T. Rye, Beatriz Zayas, A.S. Lee, John M. Essigmann, and Robert G. Croy A rationally designed genotoxin that selectively destroys estrogen receptor-positive breast cancer cells. J. Amer. Chem. Soc., 124, 1862-1863 (2001).

Jinping Gan, Paul L. Skipper, and Steven R. Tannenbaum. Oxidation of 2,6-dimethylaniline by recombinant human cytochrome P450s and human liver microsomes. Chem. Res. Toxicol., 14, 672-677 (2001).

Jacquin C. Niles, John S. Wishnok, and Steven R. Tannenbaum. Spiroiminohydantoin is the major product of the 8-oxo-7-dihydroguanosine reaction with peroxynitrite in the presence of thiols and guanosine photooxidation by methylene blue. Organic Letters, 3, 963-966 (2001).

Barbara J. Hughey, Paul L. Skipper, Robert E. Klinkowstein, Ruth E. Shefer, John S. Wishnok, and Steven R. Tannenbaum. Low-energy biomedical GC-AMS system for 14C and 3H detection. Nuclear. Inst. Methods Phys. Res. B., 172, 40-46 (2000).

Natalia Y. Tretyakova, Samar Burney, Burcak Pamir, John S. Wishnok, Peter C. Dedon, Gerald N. Wogan, and Steven R. Tannenbaum. Peroxynitrite-induced DNA damage in the supF gene: correlation with the mutational spectrum. Mutat Res., 447, 287-303 (2000).

Natalia Y. Tretyakova, John S. Wishnok, and Steven R. Tannenbaum. Peroxynitrite-induced secondary oxidative lesions at guanine nucleobases: chemical stability and recognition by the Fpg DNA repair enzyme. Chem. Res. Toxicol., 13, 658-664 (2000).

W. G. Stillwell, Paul L. Skipper, and Steven R. Tannenbaum. Biomonitoring: Methods and Analysis. In M. Nagao and T. Sugimura (eds.), Food Borne Carcinogens: Heterocyclic Amines, pp. 319-331, Chichester: John Wiley & Sons, Ltd., 2000.

Jacquin C. Niles, Samar Burney, Sukhjeet P. Singh, John S. Wishnok, and Steven R. Tannenbaum. Peroxynitrite reaction products of 3',5'-di-O-acetyl-8-oxo-7,8-dihydro-2'-deoxyguanosine. Proc. Natl. Acad. Sci. USA., 96, 11727-11734 (1999).

Lacreis C. Kidd, W.G. Stillwell, Mimi C. Yu, John S. Wishnok, Paul L. Skipper, Ronald K. Ross, Brian E. Henderson, and Steven R. Tannenbaum. Urinary excretion of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in White, African-American, and Asian-American men in Los Angeles County. Cancer Epidemiol. Biomarkers Prev., 8, 439-445 (1999).

W. G. Stillwell, Robert J. Turesky, Rashmi Sinha, and Steven R. Tannenbaum. N-oxidative metabolism of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in humans: excretion of the N2-glucuronide conjugate of 2-hydroxyamino-MeIQx in urine. Cancer Res., 59, 5154-5159 (1999).

Updated August 13, 2013 by jsw.