Xin Wang

Inflammatory Bowel Disease (IBD)
1. I will focus on developing sensitive mass spectrometric methods for the measurement of endogenous metabolic intermediates related to inflammatory bowel disease. Since these are always in very low concentration, we plan to develop some specific chemical probes and use subsequent derivatizations to capture the desired intermediates, and to then establish an LC-MS quantitation method. This should be helpful for understanding the physiological roles of the metabolic intermediates. Also, if necessary we could further improve sensitivity via suitable extraction methods or other modifications to our protocols.

2. We will also explore untargeted metabolomics and proteomics. With suitable LC-MS methods, we can profile thousands of biochemicals in biological cells, tissue or biofluids. I’d like to explore this approach to study the mechanisms and biomarkers of IBD.

Xin earned her Ph.D. in Analytical Chemistry from Peking University, China, focusing on sample pretreatment, chromatography, mass spectrometry and related fields. She joined the Wishnok/Tannenbaum mass spec lab in September 2015 as a postdoctoral associate.