Education

Sep 2001-2006:

• B. Tech, Chemical Engineering, IIT Bombay, Mumbai, India.
• M. Tech, Chemical Engineering, IIT Bombay, Mumbai, India. (Advisor: Prof. Anurag Mehra)

Sep 2006-Present:

• M.S., Chemical Engineering Practice, MIT
• Ph.D. Candidate, Chemical Engineering, MIT

Research Summary

Rational design of additives for inhibition of protein aggregation has been limited by the understanding of the mechanism of protein-additive interaction. The main focus of my current research work is to understand the mechanism by which arginine (a widely used aggregation suppressor) inhibits aggregation and apply the acquired understanding to design new additives with even better aggregation suppression ability. I am also involved in studying the mechanism by which small molecules inhibit amyloid fibril formation.

Publications

1. Shukla D., Shinde C. and Trout B.L., 2009, "Molecular Computations of Preferential Interaction Coefficients of Proteins ", J. Phys. Chem. B, Article in Press.
2. Shukla, D., Joshi A. A. and Mehra A., 2009, "Modeling of Formation of Nanoparticles in Reverse Micellar Systems: Ostwald Ripening of Silver Halide Particles", Langmuir, 25, 6, 3786-3793.
3. Sugih, A.K., Shukla, D., Heeres, H.J. and Mehra, A., 2007, "CaCO3 Nanoparticle Synthesis by Carbonation of Lime Solution in Microemulsion Systems, Nanotechnology, 18, 035607
4. Shukla, D. and Mehra, A., 2006, "Modeling the Formation of Shell in Core-Shell Nanocrystals in Reverse Micellar Systems'',  Langmuir,  22-23, 9500-9506.
   
5. Jain, R., Shukla, D. and Mehra, A., 2006,  "A Monte Carlo Model for the Formation of Core-Shell Nanocrystals in Reverse Micellar Systems'', Ind. Eng. Chem. Res., 45, 2249-2254.
   
6. Shukla, D. and Mehra, A., 2006, "A Model for Particle Coagulation in Reverse Micelles with a Size Dependent Coagulation Rate'', Nanotechnology, 17, 261-267.
7. Jain, R., Shukla, D. and Mehra, A., 2005, "Coagulation of Nanoparticles in Reverse Micellar Systems: A Monte Carlo Model'', Langmuir, 21, 11528-11533