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Massachusetts Institute of Technology
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Trout Group Member

Dr. Salvatore Mascia

Strategic Project Manager

Novartis-MIT Center for Continuous Manufacturing Department of Chemical Engineering
Massachusetts Institute of Technology
Room: 66-258
77 Massachusetts Ave.
Cambridge, MA 02139 USA

Phone: (617) 253-6675
Fax: (617) 253-2272
E-mail: smascia@mit.edu


Education

  • Oct 2004 – Oct 2008 University of Cambridge, UK   PhD in Chemical Engineering.
  • Mar 2002 - Aug 2002 School of Pharmacy (SOP), University of London, UK. Worked as an ERASMUS student for the final year project of my Laurea in Pharmacy.
  • Oct 1996 - Jan 2003 University of Perugia, Italy - Qualified as professional pharmacist (Oct 2002-Jan 2003). B.S and M.S. in Pharmacy.

Research Summary

My main research interest is in pharmaceutical manufacturing and I am currently working in the Novartis-MIT Center for Continuous Manufacturing. The Center is committed towards a transformational change in the way medicines are made, which will substantially shorten time to market of many active molecules as well as decrease production costs, and consequently the cost of medicines to patients.
To achieve our goals, we are designing and building a new prototype representing a fully integrated pharmaceutical manufacturing chain, from the synthesis of the active ingredient to the final production of the dosage form. We are introducing new technologies, which in many cases differ from any conventional pharmaceutical manufacturing approaches.
Within the Center, I am responsible for the integration of the prototype and I advise and coordinate the work of a number of PhD students. In addition, I work closely with the Director and Associate Director in leading daily operations. 

 


Publications

  1. Mascia S., Seiler C., Fitzpatrick S., Wilson D. I. (2010). Extrusion–spheronisation of microcrystalline cellulose pastes using a non-aqueous liquid binder. International Journal of Pharmaceutics 389, 1-9.
  2. Mascia, S. and Wilson, D. I. (2008). Biaxial extensional rheology of granular suspensions: the HBP (Herschel-Bulkley for Pastes) model. Journal of Rheology 52 Issue 4, 981-998.
  3. Mascia, S. and Wilson, D. I. (2007). Rheology of concentrated granular suspensions undergoing squeeze flow. Journal of Rheology 51 Issue 3, 493-515.
  4. Mascia, S., Patel, M. J., Rough, S. L., Martin, P.J. and Wilson, D. I. (2006). Liquid phase migration in the extrusion and squeezing of microcrystalline cellulose pastes. European Journal of Pharmaceutical Sciences, 29, 22-34.
  5. Carter, Roy E. ; Newton, J.M. ; Caminho, Ana M. ; Mascia, S. (2004)  A novel system for the controlled release of drugs. Pharmaceutical Technology Europe. December issue.

 



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Last Updated: November 24, 2010