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Undergraduates
have the opportunity
to participate
in a variety
of research
areas. A partial
list of available
research topics
and faculty
advisors appears
below. Students
may consult
with the Coordinator
for more detailed
information
and are encouraged
to speak directly
with faculty
supervisors.
Instruction forms on procedures
for registering for 5.UR
and 5.URG are available
from the Chemistry Education
Office (2-204). Credit is
obtained for undergraduate
research by registering
for course 5.UR or 5.URG
and by submitting a for credit UROP
application before the UROP office deadlines.
To receive credit, students
enrolled in 5.UR (research
for Pass/Fail grade) must
file a Progress Report with
the UROP coordinator. Subject
5.URG (research for Letter
Grade) is open to juniors
and seniors for 9 or 12
units per semester. To receive
credit, students are required
to submit a ten-page final
written report to their
research advisor prior to
the last day of classes.
All new
UROP students
in the
Department
of Chemistry
must complete the Training
Needs Assessment form
which
is accessible
through
the EH&S
Office's
training
web site.
An MIT Certificate is
required
along with a Kerberos
username
and MIT I.D. the above
address
will bring you to the
EH&S
Office's home page.
Follow
the link to EH&S
training. Verify that
the user information
is correct and complete
the Training Needs Assessment
Form. This will provide
a list of training requirements
and information on how
to complete them. Virtually
all researchers (with
the exception of some
theoretical chemists)
will be required at
a minimum, to complete
the following steps
prior to begining work
in areas where hazardous
chemicals are in use. Even
if you do not work in
areas where hazardous
chemicals are in use,
you will still need
to complete step 5,
listed below.
- Attend
the Chemical
Hygiene and Safety
Lecture
presented
in January
or view a DVD
copy of
the lecture.
Copies of
the lecture
can be borrowed
from Chemistry
Headquarters in
room 18-393.
- Read
and
understand
the Chemistry
Department
Chemical
Hygiene
Plan
and Safety
Manual.
Copies
of the
book can
be obtained
in Chemistry
Headquarters
in room
18-393.
- Receive
Initial
Lab Specific
Chemical
Hygiene
Plan and
Safety
Training
from your
Laboratory
Supervisor
or their
designee
(you
will need
to obtain
the laboratory
Supervisor's
signature
on the
EH&S
Clearance
form).
- Complete
the
training
course, Managing
Hazardous
Waste.
This
is offered
as a
web
based
course
and
is accessible
through
the
EH&S
office's
training
website
mentioned
above.
this
is an
annual
requirement.
As the
expiration
date
approaches,
an automatic
e-mail
reminder
will
be sent
to indicate
that
you
must
log
on to
the
training
website
and
complete
the
web
course
again.
- Obtain
the
EH&S
Clearance
form
from Chemistry
Headquarters
in 18-393.
New
UROP students
must
sign the
EHS Clearance
Form
and submit
it to
Chemistry
Headquarters,
indicating
that
all training
requirements
stated
on the
form
have been
met. In
the case
that work
will not
be performed
with
hazardous
substances
or in
areas
where
hazardous
substances
are
in use,
the laboratory
supervisormust
sign
the form.
Please contact
Jim Doughty
EH&S Coordinator
(324-6132,
jdoughty@mit.edu)
with any questions.
- Prof.
Moungi
Bawendi, 6-221,
x3-9796, mgb@mit.edu
-
Bawendi Group Homepage
Science and application of semiconductor and magnetic nanocrystals. Synthesis, characterization, spectroscopy, applications to opto-electronic devices including photodetectors, photovoltaics and light emission, and applications in biological and biomedical imaging.
-
- Prof.
Stephen
L. Buchwald,
18-490,
x3-1885, sbuchwal@mit.edu
-
Buchwald Group Homepage
Organic
synthesis
based on
organotransition
metal technology,
mechanisms
of organometallic
reactions,
main group
and transition
metal organometallic
chemistry.
-
- Prof.
Sylvia
T. Ceyer, 6-217,
x3-4537, stceyer@mit.edu
-
Ceyer Group Homepage
Experimental studies of the dynamics of the interactions of molecules with solid surfaces, including investigations of mechanisms of heterogeneous catalysis and etching reactions.
- Prof.
Christopher
C. Cummins,
6-435,
x3-5332, ccummins@mit.edu
- Cummins Group Homepage
Inorganic
radical
chemistry.
Activation
of small
molecules
including
dinitrogen
and the
nitrogen
oxides.
Development
of new synthetic
methods
for inorganic
chemistry.
-
- Prof.
Rick L.
Danheiser, 18-298,
x3-1842, danheisr@mit.edu
-
Danheiser Group Homepage
Development of new methods for the synthesis of organic compounds; applications to synthesis of biologically important compounds. Green chemistry, including the development of environmentally friendly methods for chemical synthesis.
- Prof.
Catherine
L. Drennan, 16-573A,
x3-5622, cdrennan@mit.edu
- Drennan Group Homepage
Structure and function studies of metalloenzymes that are medically important or involved in environmental remediation
- Prof.
John M.
Essigmann,
56-669B,
x3-6227, jessig@mit.edu,
- Essigmann
Group
Home Page
- Biochemical and molecular mechanisms of cancer induction by chemicals and radiation; mechanisms for DNA repair; and design of novel anti-tumor agents that hijack transcription factors.
- Prof.
Robert
W. Field,
6-219,
3-1489, rwfield@mit.edu, Field
Group
Page
- Multiple resonance laser spectroscopy of small molecules in pulsed supersonic molecular beams using a variety of cw, nanosecond, and femtosecond lasers, in combination with both cw and chirped-pulse millimeter-wave sources. Projects include construction of sources of transient molecules, optimization of signal detection devices, generation of software for laser- scan control, data acquisition, spectrum calibration, and development of unconventional models to fit frequency-domain spectra and to visualize the dynamical mechanisms encoded in these spectra.
- Prof.
Gregory
C. Fu, 18-290,
x3-2664, gcf@mit.edu
-
Fu Group Homepage
Development
of new reagents
and methods
for organic
chemistry,
with an
emphasis
on asymmetric
catalysis,
and elucidation
of reaction
mechanisms.
-
- Prof.
Robert
G. Griffin,
NW14-322,
x3-5597, griffin@ccnmr.mit.edu
-
- Nuclear
magnetic
resonance
in solids,
applications
of NMR to
biological
problems,
high field
dynamic
nuclear
polarization
and pulsed
EPR.
-
- Prof.
Barbara
Imperiali, 18-590,
x3-1838, imper@mit.edu
- Imperiali
Group
Protein structure, function,
and design. Multidisciplinary
approach employs synthesis,
spectroscopy, molecular
modeling, enzymology and
molecular biology to address
fundamental problems at
the interface of chemistry
and biology.
-
- Prof.
Timothy
F. Jamison, 18-492,
x3-2135, tfj@mit.edu
-
Jamison Group Homepage
Organic
Chemistry.
Development
of new organic
reactions
and their
use in the
synthesis
of natural
products
and related
molecules.
-
- Prof.
Alexander
M. Klibanov, 56-579,
x3-3556, klibanov@mit.edu
- Enzymes as catalysts in organic chemistry, enzymatic catalysts in non-aqueous media, microbicidal materials, delivery of pharmaceutical proteins and nucleic acids.
- Prof.
Stuart Licht, 16-573B,
452-3525, lichts@mit.edu
-
Licht Group Homepage
Mechanistic
studies
of enzymes
and ion
channels.
One area
of interest
is how enzymes
and ion
channels
may use
ATP hydrolysis
as an energy
source to
carry out
conformational
changes
that would
otherwise
be energetically
disfavored.
Another
general
area of
interest
is investigating
how protein-protein
interactions
affect protein
function.
For example,
under some
circumstances,
the opening
of one ion
channel
can influence
the probability
that a neighboring
ion channel
will open.
Similarly,
when the
product
of an enzymatic
reaction
affects
the activity
of an ion
channel
(or another
enzyme),
physical
association
between
the two
proteins
may link
the proteins
functionally
by producing
a high effective
concentration
of that
product
near its
binding
site. A
third area
of interest
is engineering
metal binding
sites into
ion channels
as a tool
for studying
ion channel
gating and
bioinorganic
reactivity
at the single-molecule
level.
- Prof.
Stephen
J. Lippard, 18-498,
3-1892, lippard@mit.edu,
- Lippard
Group
Home Page
- Platinum
anticancer
drugs; synthetic chemistry related to diiron metalloenzymes; structural and mechanistic studies of bacterial monooxygenases, including soluble methane monooxygenase; metalloneurochemistry, including mobile zinc and nitric oxide in the brain; nitric oxide chemistry of zinc and iron thiolates and clusters.
- Prof. Mohammad Movassaghi, 18-292, x3-3986, movassag@mit.edu
- Movassaghi Group Homepage
Complex natural product total synthesis. Discovery, development, and mechanistic studies of new reactions for organic synthesis.
- Prof.
Keith
A. Nelson, 6-235,
x3-1423, kanelson@mit.edu
-
Nelson Group Homepage
Picosecond
and femtosecond
laser spectroscopy
of phase
transitions,
liquid-glass
transitions,
chemical
reactions,
and other
condensed
matter phenomena;
thin film
characterization;
nonlinear
interactions
of light
with condensed
matter;
optical
control
over material
behavior.
- Prof. Sarah E. O’Connor, 18-592, 324-0180, soc@mit.edu
-
O’Connor Group Homepage
The O’Connor group studies natural product biosynthesis. We use nature’s biosynthetic pathways to make complex molecules.
- Prof. Jonas C. Peters, 18-296, 3-1819, jcpeters@mit.edu
- Peters Group Home Page: http://web.mit.edu/petersgroup/ inorganic/ organometallic synthesis, small molecule activation, redox reactions, catalytic energy conversion
- Prof. Richard Schrock, 6-331, x3-1596, rrs@mit.edu, Schrock Group
- Schrock Group Homepage
Organometallic
synthesis,
mechanisms,
homogeneous
catalysis,
olefin metathesis,
reduction
of dinitrogen,
new polymers,
asymmetric
olefin metathesis,
living polymerization
of olefins.
- Prof.
Robert
J. Silbey,
6-129,
x3-1470, silbey@mit.edu
- Quantum
and statistical
mechanics
especially
applied
to relaxation
processes
in molecules
and condensed
phases.
(Completion
of 5.61
and 5.62
desirable.)
- Prof.
Joanne
Stubbe, 18-598,
x3-1814, stubbe@mit.edu,
- Mechanisms
and structure
of enzymatic
reactions
including
ribonucleotide
reductases,
purine biosynthetic
pathway
enzymes,
enzymes
involved
in DNA repair
and enzymes
involved
in making
biodegradable
polyesters
and rubber;
structure
and mechanisms
of DNA cleavers
such as
bleomycins,
natural
products
used clinically
in the treatment
of cancer;
design of
mechanism
based inhibitors
as tools
to study
mechanism
and as potential
cancer,
antiviral
and antibacterial
therapeutics;
use of molecular
biological
methods
including
site directed
mutagenesis,
use of rapid
kinetics
methods
including
stopped
flow and
rapid freeze
quench to
study intermediates
in reactions;
use of yeast
as a model
system to
investigate
iron homeostasis
and how
metallo-cofactors
of proteins
are generated
in vivo;
use of yeast
as a model
system to
study DNA
replication
and repair
by modulation
of deoxynucleotide
pools.
-
- Prof.
Timothy
M. Swager, 18-398,x3-1801, tswager@mit.edu,
- Swager
Group
Home Page Supramolecular
and materials
chemistry
with an
emphasis
on the
synthesis
and construction
of functional
assemblies.
Since
chemosensors
require
recognition
elements
to discriminate
chemical
signals,
molecular
recognition
pervades
the research.
Also,
integration
of molecular
recognition
principles
in the
design
of supramolecular
catalysts
provide
unique
specificity
and mimic
the characteristics
of enzymes.
In the
area of
liquid
crystals,
molecular
complementary
and receptor-ligand
interactions
provide
novel
organizations.
-
- Prof.
Steven
R. Tannenbaum, 56-731A,
x3-3729, srt@mit.edu
-
Tannenbaum Group Homepage
Applications of chromatography, mass spectrometry, and affinity methods for identification, detection, and analysis of biological molecules. Applications include inflammation (nitric oxide), liver function and toxicology, proteomics, metabolomics, drug development.
- Prof.
Alice Y. Ting,
18-496,
452-2021, ating@mit.edu
-
Ting Group Home Page
Design
and synthesis
of new molecules
for probing
signal transduction
in living
cells. Fluorescent reporters
for protein trafficking, enzyme activity, post-translational modifications, receptor recycling, and protein-protein interactions. Directed evolution of new ligases for site-specific labeling of recombinant proteins in living cells. Improved quantum dots for single-molecule imaging of proteins in living cells.
-
- Prof.
Andrei
Tokmakoff, 6-225,
x3-4503, tokmakof@mit.edu
-
Tokmakoff Group Home Page
Development and use of time-resolved spectroscopy for studies of chemical and biological dynamics. Design of experiments to study transient structure and confirmation of proteins, peptides, and other molecules in solution. Protein folding and unfolding kinetics; protein dimerization and aggregation. Synthesis of isotope-edited peptides for spectroscopic studies of folding. Hydrogen bond network rearrangements in water. Proton transfer mechanisms in water. Study of proton transfer mediated by hydrogen bonds. Collective structure and structural change of liquids. Development and use of two-dimensional vibrational spectroscopy.
- Prof. Troy Van Voorhis, 6-229, x3-1488, tvan@mit.edu
- Van Voorhis Group Homepage
- Electronic structure theory of molecules. Investigation of the mechanisms
and dynamics of electron transfer reactions. Accurate description of
excited state chemistry.
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