VFRL Selected research areas 
Mechanotactic cell aggregation
Dr. Roland Bouffanais

Mechanotactic cell motility has recently been shown to be a key player in the initial aggregation of crawling cells such as leukocytes and amoebae.

The effects of mechanotactic signaling in the early aggregation of amoeboid cells are investigated using a general mathematical model based upon known biological evidences. We try to elucidate the hydrodynamic fundamentals of the direct guiding of a cell through mechanotaxis. The mesoscopic pattern of aggregation is obtained which constitutes the bridge between, on the one hand, the microscopic world where the changes in the cell shape occur the cooperative behavior of the cells at the mesoscopic scale on the other.

R. Bouffanais and D. K. P. Yue, "Hydrodynamics of cell-cell mechanical signaling in the initial stages of aggregation",
Phys. Rev. E, (81), 041920, 2010. pdf, doi

Also selected to appear in:

  • Virtual Journal of Biological Physics Research, (19), Issue 9, May 1, 2010. http://www.vjbio.org
  • Virtual Journal of Nanoscale Science and Technology, (21), Issue 19, May 10, 2010. http://www.vjnano.org
  • Kaleidoscope Images of Phys. Rev. E, web