Recent technological and experimental advances in the capabilities to record signals from neural systems have led to an unprecedented increase in the types and volume of data collected in neuroscience experiments and hence, in the need for appropriate techniques to analyze them. Therefore, using combinations of likelihood, Bayesian, state-space, time-series and point process approaches, a primary focus of the research in my laboratory is the development of statistical methods and signal-processing algorithms for neuroscience data analysis.
We have used our methods to:
Understanding General Anesthesia
General anesthesia is a neurophysiological state in which a patient is rendered unconscious, insensitive to pain, amnestic, and immobile, while being maintained physiologically stable. General anesthesia has been administered in the U.S. for more than 160 years and currently, more than 100,000 people receive anesthesia daily in this country for surgery alone. Still, the mechanism by which an anesthetic drug induces general anesthesia remains a medical mystery. My laboratory is using a systems neuroscience approach to study how the state of general anesthesia is induced and maintained. To do so, we are using fMRI, EEG, neurophysiological recordings, microdialysis methods and mathematical modeling in interdisciplinary collaborations with investigators in BCS, the MIT/Harvard Division of Health Science and Technology, Massachusetts General Hospital and Boston University. The long-term goal of this research is to establish a neurophysiological definition of anesthesia, safer, site-specific anesthetic drugs and to develop better neurophysiologically-based methods for measuring depth of anesthesia.
Srinivasan L, Eden UT, Mitter SK, Brown EN. General purpose filter design for neural prosthetic devices. Journal of Neurophysiology, 2007, 98(4): 2456-2475.
Czanner G, Eden UT, Wirth S, Yanike M, Suzuki WA, Brown EN. Analysis of between-trial and within-trial neural spiking dynamics. Journal of Neurophysiology, 2008, May; 99(5):2672-93.
McCarthy MM, Brown EN, Kopell NK. Potential network mechanisms mediating electroencephalographic beta rhythm changes during propofol-induced paradoxical excitation. Journal of Neuroscience, 2008, Dec 10; 28(50):13488-504.
Purdon PL, Pierce ET, Bonmassar G, Walsh JL, Harrell PG, Kwo J, Deschler D, Barlow M, Merhar RC, Lamus C, Mullaly CM, Sullivan M, Maginnis S, Skoniecki D, Higgins H, Brown EN. Simultaneous electroencephalography and functional magnetic resonance imaging of general anesthesia. Annals of the New York Academy of Science, 2009, 1157: 61-70.