| Internal
Validity |
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| • | Does
credible physiological theory suggest |
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| mechanism
of action? |
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| • | Persuasive
studies in animals? |
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| • | Replicated
in other human studies? |
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| – | FDA
requirement for two RCTs |
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| • | Study
undertaken by team with good |
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| credentials? |
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| • | Was
publication in peer-reviewed journal? |
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