7.72 For Class Members

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General Information

The readings will be posted as the term progresses. The lecture notes are available both as PDF handouts (2 slides/pg) and online slideshows. The readingsand handouts links are PDF files unless otherwise stated.

Syllabus, Fall 2006

Date	lecturer	Topic	lecture handouts and readings
9/6	HS	Introduction (handout) (slideshow)	terms to know Student Presentation Schedule
9/11	HS	Axis formation I (dorsoventral axis) (handout) (slideshow)
9/13		Axis formation I (papers)	Gerhart et al. Lowe et al.
9/18	HS	Axis formation II (anteroposterior axis) (handout) (slideshow)	terms and information self-quiz
9/20		Axis formation II (papers) (study questions) (handout) (slideshow)	Kudoh et al. Marletaz et al. Stern et al.
9/25		Student Holiday, no class
9/27	Levin	Axis formation III (left-right axis) (handout, pdf, 1 slide/pg)	Review - Left-Right Assymetry (Levin) terms and information
10/2		Yom Kippur, no class
10/4		Axis formation III (papers) (study questions) (Notch Signalling)	Raya et al Raya Review Comment on Raya
10/9		Columbus Day, no class
10/11	HS	Cell type: Nervous system I (slideshow) (handout, pdf) (terms)	Comment on Mandel Wodarz
10/16		Cell type: Nervous system I (papers) (study questions)	Gotz Review Freeman Review Sun et al. Comment on Sun Neuron article
10/18	Schultheiss	Organogenesis (handout) (slideshow)
10/23		Organogenesis (papers) (study questions)	Davidson Heart figures, Gilbert ch15 Olson Review Passamaneck Review
10/25	Horvitz	C. elegans
10/30		C. elegans (papers) (study questions)	Anderson, Lu, Horvitz 2006 Fay & Han 2000 Synthetic Phenotypes handout
11/1		Morphogenesis (study questions) (handout) (slideshow - w/animations)
11/6		Morphogenesis (papers) (study questions)	Wallingford 2001 Wallingford 2002 Wallingford Review Zohn Review
11/8	Camargo	Stem cells (handout) (slideshow)
11/13		Stem cells (papers) (study questions) Signaling quiz / answer key	Blanpain et al. Blanpain & Fuchs Review Moore & Lemischka Review
11/15	Raftery	Drosophila (lecture notes)	Blair Review
11/20		Drosophila (papers)	Belenkaya et al. O'Connor Review Gurdon Review Ashe Review
11/22		Thanksgiving! no class
11/27	HS	Cell type: Nervous system II (handout) (slideshow)	Some adjunct papers: Fucillo hedgehog review Millen roof plate review Placzek floor plate review Reichert urbilaterian review
11/29	HS	Cell type: Nervous system II (papers) (study questions)	Nordstrom et al. Maden spinal cord review Kudo et al. - REVISITED Kessel review - REVISITED Diez del Corral - review
12/4	HS	Epigenetics and cloning (handout) (slideshow)
12/6	HS	Epigenetics and cloning (papers) (study questions)	Klose and Bird review Sun et al Thorvaldsen et al review
12/11	HS	Issues in human development - lecture and paper discussion	Chung et al Assisted Reproductive Technologies booklet Preimplantation genetic diagnosis - review IVF defects Huntington's - overview Confidentiality Ethics in Huntington's Stem Cells - commentary
12/13	HS	Putting it together: lessons learned and to learn (class)	Final Requirements

Final Paper Assignments:

Bailey et al (placodal specification): John Cassady; Sylvain Lapan; Noah Spies
Gibert et al (pectoral fin formation): David Garcia; Emma Lubin; Scott Valastyan
Jancovics and Brunner (dorsal closure): Robin Friedman; Mitchell Guttman; Warren Whyte
Koppen et al (epithelial movement): Jeffrey Millman; Shuyin Sim; Paul Valiant
Taylor and LaBonne (neural crest): Eliezer Calo; Jessica Chang; Heidi Holley

Embryonic Stages - websites of interest:

Mouse
http://genex.hgu.mrc.ac.uk/Atlas/intro.html
Chicken
Hamburger Hamilton stages
Also check this one out: still being built, but nicely organized
Xenopus
Photos
Drawings (Nieuwkoop Faber stages)
Zebrafish
http://zfin.org/zf_info/zfbook/stages/index.html
Drosophila
http://flybase.bio.indiana.edu/allied-data/lk/interactive-fly/aimain/2stages.htm
Caenorhabditis
http://www.wormatlas.org/handbook/anatomyintro/anatomyintro.htm#Lifecycle