8.592 - HST.452J (Spring 2022)

Statistical Physics in Biology

Lecture 14

(zoom link: https://mit.zoom.us/j/93992933747)

Recording for zoom session

Kinetics of protein folding

1. Review of Random Energy Model (REM) [B. Derrida, Physics Reports 67, 29 (1980)]
2. Application of REM to protein folding
• Bryngelson and Wolynes
• Need a well defined native state competing with a continuum of competing (decoy) compact states
• Designed REM
3. Chemical kinetic, Arrhenious Law
4. Phenomenologial model (after Gutin et.al.)

(Lecture notes from 2022)

(Slides)

(Lecture notes)