8.592 - HST.452J (Spring 2022)

Statistical Physics in Biology

Lecture 19

(zoom link: https://mit.zoom.us/j/93992933747)

Link for (partial) zoom recording

Protein-DNA Interactions

1. Regulation of genes by protein-DNA interactions  (slides)
• Lac repressor
• CRP activation
• Recruitment of polymerase
2. Structure of protein-DNA complexes 
• Lac repressor
• Specificity
• Bonds
• DNA bending, non-direct readout

(Lecture note from 4/1/2022)

• Mirny lecture notes on protein-DNA interactions from 2018
• Protein-DNA energetics
• (Lecture note from 4/13/2020)